| Project/Area Number |
20599023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Department of Clinical Research National Hospital Organization, National Sanyo Hospital |
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Principal Investigator |
YUSUKE Mimura Department of Clinical Research National Hospital Organization, National Sanyo Hospital, 臨床研究部, 生理生化学研究室長 (00219718)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,360,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | 抗原認識 / 抗原提示 / MHCクラスII分子 / CD4+T細胞 / 癌ワクチン / Protein folding / MHC class II molecules / CD4+ T cells / MHC classII molecule |
|---|
| Research Abstract |
Efficient antigen presentation to CD4+ T cells is essential for activation of anti-tumor immunity. In order to elicit robust T cell responses with smaller doses of antigen, we have designed a new vaccine in which a CD4+ T cell epitope of ovalbumin is inserted in the complementary determining region of an immunoglobulin molecule. This inserted epitope is supposed to be presented to CD4+ T cells after direct binding to a recycling MHC class II molecule on the surface of an antigen presenting cell and processing in the endosome, in contrast to the known processing pathway involving the late endosomes and lysosomes.
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