Functional change in descending pain modulatory system induced by chronic stresses

• Project/Area Number: 20602005
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 疼痛学
• Research Institution: Wakayama Medical University
• Principal Investigator: IMBE Hiroki 和歌山県立医科大学, 医学部, 講師 (60326353)
• Co-Investigator(Kenkyū-buntansha): SENBA Emiko 和歌山県立医科大学, 医学部, 教授 (00135691)
• Co-Investigator(Renkei-kenkyūsha): KIMURA Akihisa 和歌山県立医科大学, 医学部, 准教授 (20225022)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ストレス / 疼痛学 / 下行性疼痛調節系 / 下行正疼痛調節系

Research Abstract

Chronic stress is thought to have the effect that enhances pain sensitivity. It has previously been reported that repeated exposure to cold environment, restraint and forced swim for animal produces hyperalgesia(enhancement of nociceptive reaction). However the mechanism underlying chronic stress-induced hyperalgesia remains unknown. There is descending pain modulatory system that controls perception and response to pain in animal and human brains. In the present study we did not observe chronic stress-induced hyperalgesia in the animal with partial lesion of descending pain modulatory system. These results have demonstrated that the input from descending pain modulatory system is involved in chronic stress-induced hyperalgesia.

Research Products

• [Journal Article] Activation of Mitogen-Activated Protein Kinase in Descending Pain Modulatory System (2011)
  • Author(s): Imbe, H. Senba E. Kimura A, Donishi T, Yokoi I, Kaneoke Y.
  • Journal Title: J Signal Transduct Volume: 2011 Pages: 10-10
  • DOI: 10.1155/2011/468061
  • Peer Reviewed
• [Journal Article] Activation of Mitogen-Activated Protein Kinase in Descending Pain Modulatory System. (2011)
  • Author(s): Imbe,H.Senba E.Kimura A, Donishi T, Yokoi I, Kaneoke Y.
  • Journal Title: J Signal Transduct. in press
  • Peer Reviewed
• [Journal Article] Activation of Mitogen-Activated Protein Kinase in Descending Pain Modulatory System. (2011)
  • Author(s): Imhe, et al.
  • Journal Title: J.Signal Transduct. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Involvement of descending facilitation from the rostral ventromedial medulla in the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress (2010)
  • Author(s): Imbe H. Okamoto K. Donishi T. Senba E. Kimura A.
  • Journal Title: Brain Res Volume: 1329 Pages: 103-112
  • Peer Reviewed
• [Journal Article] Involvement of descending facilitation from the rostral ventromedial medulla in the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress. (2010)
  • Author(s): Imbe H.Okamoto K.Donishi T.Senba E.Kimura A.
  • Journal Title: Brain Res 1329 Pages: 103-112
  • Peer Reviewed
• [Journal Article] Involvement of descending facilitation from the rostral ventromedial medulla in the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress (2010)
  • Author(s): Imbe, et al.
  • Journal Title: Brain Research Volume: 1329 Pages: 103-112
  • Peer Reviewed
• [Journal Article] Involvement of descending facilitation from the rostral ventromedial medulla in the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress (2010)
  • Author(s): Imbe, et al.
  • Journal Title: Brain Research (in press)
  • Peer Reviewed
• [Journal Article] Activation of ERK in the locus coeruleus following acute noxious stimulation (2009)
  • Author(s): Imbe, et al.
  • Journal Title: Brain Research 1263 Pages: 50-57
  • Peer Reviewed
• [Presentation] Involvement of descending facilitation from the rostral ventromedial medulla in the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress. (2010)
  • Author(s): Hiroki Imbe, Akihisa Kimura, Tomohiro Donishi, Emiko Senba, Yoshiki Kaneoke.
  • Organizer: The 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-11-17
• [Presentation] ストレスによる痛覚過敏のメカニズム.下行性疼痛調節系の関与 (2010)
  • Author(s): 仙波恵美子、井辺弘樹
  • Organizer: Neuro2010(第33回日本神経科学大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] ストレスによる痛覚過敏のメカニズム.下行性疼痛調節系の関与.Neuro2010 (2010)
  • Author(s): 仙波恵美子、井辺弘樹.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] シンポジウムストレスによる痛覚過敏のメカニズム-下行性疼痛調節系の関与 (2010)
  • Author(s): 仙波恵美子、井辺弘樹
  • Organizer: Neuro2010(第33回日本神経科学大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] 慢性拘束ストレスは吻側延髄腹内側部においてGAP43蛋白質分解フラグメントを増加する (2010)
  • Author(s): 井辺弘樹、堂西倫弘、木村晃久
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-05-19
• [Presentation] 慢性拘束ストレスは吻側延髄腹内側部においてGAP43蛋白質分解フラグメントを増加する. (2010)
  • Author(s): Imbe H, Donishi T, Senba E, Kimura A.
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-05-19
• [Presentation] Involvement of descending facilitation from the rostral ventromedial medulla in the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress (2010)
  • Author(s): Hiroki Imbe, Akihisa Kimura, Tomohiro Donishi, Emiko Senba, Yoshiki Kaneoke
  • Organizer: The 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Participation of descending facilitation from the rostral ventromedial medulla in repeated swim stress-induced hyperalgesia. (2009)
  • Author(s): 井辺弘樹, 堂西倫弘, 仙波恵美子, 木村晃久.
  • Organizer: The 36th International Congress of Physiological Sciences (IUPS2009)
  • Place of Presentation: Kyoto
  • Year and Date: 2009-07-30
• [Presentation] Participation of descending facilitation from the rostral ventrome dial medulla in repeated swim stress-induced hyperalgesia (2009)
  • Author(s): Imbe, et al.
  • Organizer: The 36th International Congress of Physiological Sciences(IUPS2009)
  • Place of Presentation: Kyoto
  • Year and Date: 2009-07-30
• [Presentation] 強制水泳ストレス負荷後の疼痛反応増強における吻側延髄腹内側部の関与 (2009)
  • Author(s): 井辺弘樹、仙波恵美子
  • Organizer: 第31回日本疼痛学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-18
• [Presentation] コメディカルとともに痛みを学ぶワークショップ慢性ストレスにより痛みが増悪するメカニズムー下行性疼痛調節系の関与 (2009)
  • Author(s): 仙波恵美子、井辺弘樹
  • Organizer: 第31回日本疼痛学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-18
• [Presentation] 強制水泳ストレス負荷後の疼痛反応増強における吻側延髄腹内側部の関与. (2009)
  • Author(s): 井辺弘樹、仙波恵美子
  • Organizer: 第31回日本疼痛学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-18
• [Presentation] コメディカルとともに痛みを学ぶワークショップ慢性ストレスにより痛みが増悪するメカニズムー下行性疼痛調節系の関与. (2009)
  • Author(s): 仙波恵美子、井辺弘樹
  • Organizer: 第31回日本疼痛学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-18
• [Presentation] Participation of descending facilitation from the rostral ventromedial medulla in repeated swim stress-induced hyperalgesia (2009)
  • Author(s): Imbe H, Donishi T, Senba E, Kimura A.
  • Organizer: The 36th International Congress of Physiological Sciences(IUPS2009) July30
  • Place of Presentation: Kyoto
• [Presentation] Activation of ERK in the locus coeruleus induced by acute noxious stimulation. (2008)
  • Author(s): Imbe H, et al.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, DC. USA
  • Year and Date: 2008-11-15
• [Remarks]
  • URL: http://www.wakayama-med.ac.jp/med/physiology1/Dept_of_Physiology,_Wakayama_Medical_University/jiao_shi_shao_jie.html
• [Remarks]
  • URL: http://www.wakayama-med.ac.jp/med/physiologyl/Dept_of_Physiology,_Wakayama_Medical_University/jiao_shi_shao_jie.html