| Project/Area Number |
20602006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
|
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| Research Institution | Keio University |
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Principal Investigator |
ASADA Hironori Keio University, 医学部, 講師 (60231883)
|
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| Co-Investigator(Kenkyū-buntansha) |
FURUYA Masataka 慶應義塾大学, 医学部, 助教 (70317197)
KAJITANI Takashi 帝京大学, 医学部, 助教 (60407111)
MARUYAMA Tetsuo 慶應義塾大学, 医学部, 講師 (10209702)
YOSHIMURA Yasunori 慶應義塾大学, 医学部, 教授 (10129736)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 子宮内膜症 / 疼痛 / NGF |
|---|
| Research Abstract |
Endometriosis is associated with disruption of women's reproductive health, in terms of pelvic pain and infertility. However mechanisms of endometriosis related pain still remain unclear. To obtain a clue to elucidate the molecular mechanisms underling the endometriosis related pain, we investigated the concentration of nerve growth factor (NGF) in ascites. The expression and localization of NGF and lipoxygenase related genes were also investigated. NGF, 5-lox, and 15-lox are locally produced from endometriotic lesion. These locally expressed genes may contribute to the generation and maintenance of acute and chronic pelvic pain, such as dysmenorrhea and dyspareunia.
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