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Effects of exercise on immobilization-induced pain and its prevention

Research Project

Project/Area Number 20602008
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 疼痛学
Research InstitutionNagoya Gakuin University

Principal Investigator

KOEDA TOMOKO  Nagoya Gakuin University, リハビリテーション学部, 准教授 (20223050)

Co-Investigator(Kenkyū-buntansha) NISHIGAMI Tomohiko  甲南女子大学, 看護リハビリテーション学部, 准教授 (60515691)
田崎 洋光  名古屋学院大学, 人間健康学部・人間健康学部, 講師 (50367877)
水村 和枝  名古屋大学, 環境医学研究所, 教授 (00109349)
Co-Investigator(Renkei-kenkyūsha) MIZUMURA Kazue  名古屋大学, 環境医学研究所, 教授 (00109349)
Research Collaborator OKUMURA Syoji  名古屋学院大学
NISHII Chihiro  東名ブレース株式会社
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords不動化ラット / 疼痛閾値 / ストレッチング / トレッドミル走 / 運動習慣 / 自由運動 / 疼痛行動 / 先取り鎮痛 / ギプス固定ラット / 痛み / トレッドミル / ストレッチ
Research Abstract

The purpose of this study was to examine whether the immobilization-induced pain was influenced by some therapeutic exercises. Cast was placed at the ankle in full plantar flexed position for 4 weeks. Rats exercised by treadmill running for 15 min/day, free moving for 15 min/day or stretching for 30 min/day, 5-6 days/week during immobilization period. The nociception behaviors in free moving and stretching group were decreased compared with rats received immobilization only. Moreover, it was clarified that the pain was reduced by treadmill running before immobilization.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (49 results)

All 2011 2010 2009 2008 Other

All Journal Article (27 results) (of which Peer Reviewed: 19 results) Presentation (14 results) Book (4 results) Remarks (4 results)

  • [Journal Article] 関連痛部位に対する圧刺激は関連痛を軽減させる2011

    • Author(s)
      肥田朋子、柴田莉紗、他
    • Journal Title

      Pain Rehabil 1

      Pages: 7-11

    • NAID

      40019800968

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 関連痛部位に対する圧刺激は関連痛を軽減させる2011

    • Author(s)
      肥田朋子
    • Journal Title

      Pain Rehabilitation

      Volume: 1(印刷中)

    • NAID

      40019800968

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscle Meterによる筋の硬さ測定-他の筋硬度計との有用性の比較-2010

    • Author(s)
      天野幸代、肥田朋子
    • Journal Title

      名古屋学院大学論集 47(2)

      Pages: 83-9

    • NAID

      120005662350

    • Related Report
      2010 Final Research Report
  • [Journal Article] 痛み刺激による前頭前野の即時的な脳血流量変化2010

    • Author(s)
      西上智彦、池本竜則、他
    • Journal Title

      Pain Res 25(3)

      Pages: 127-134

    • NAID

      10026548180

    • Related Report
      2010 Final Research Report
  • [Journal Article] 痛みに対するリハビリテーション-脳科学・痛み学の視点からのアプローチ-2010

    • Author(s)
      西上智彦, 渡邉晃久
    • Journal Title

      認知運動療法研究 9

      Pages: 83-107

    • NAID

      40017057129

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bradykinin and nerve growth factor play pivotal roles in muscular mechanical hyperalgesia after exercise (delayed-onset muscle soreness).2010

    • Author(s)
      Murase S, Mizumura K, et al.
    • Journal Title

      J Neurosci 30(10)

      Pages: 3752-3761

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Persistent deep mechanical hyperalgesia induced by repeated cold stress in rats.2010

    • Author(s)
      Nasu T, Taguchi T, Mizumura K
    • Journal Title

      Eur J Pain 14(3)

      Pages: 236-244

    • NAID

      120002015002

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Augmented mechanical response of muscular thin-fiber receptors in aged rats recorded in vitro.2010

    • Author(s)
      Taguchi T, Mizumura K
    • Journal Title

      Eur J Pain. (In press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Muscle Meterによる筋の硬さ測定-他の筋硬度計との有用性の比較-2010

    • Author(s)
      天野幸代
    • Journal Title

      名古屋学院大学論集

      Volume: 47(2) Pages: 83-89

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 痛み刺激による前頭前野の即時的な脳血流量変化2010

    • Author(s)
      西上智彦
    • Journal Title

      Brain Res

      Volume: 25(3) Pages: 127-134

    • NAID

      10026548180

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 筋硬度計による生体の硬さ測定―再現性と妥当性と有用性―2010

    • Author(s)
      肥田朋子, 天野幸代
    • Journal Title

      名古屋学院大学論集人文・自然科学編 46(2)

      Pages: 55-61

    • NAID

      130004581789

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ラット足関節不動化による活動制限は痛みを促進する2009

    • Author(s)
      山本綾、肥田朋子、他
    • Journal Title

      理学療法学 36(6)

      Pages: 305-311

    • NAID

      110007467994

    • Related Report
      2010 Final Research Report
  • [Journal Article] 筋硬度計による生体の硬さ測定-再現性と妥当性と有用性-2009

    • Author(s)
      肥田朋子、天野幸代
    • Journal Title

      名古屋学院大学論集 46(2)

      Pages: 55-61

    • NAID

      130004581789

    • Related Report
      2010 Final Research Report
  • [Journal Article] Increased pain from muscle fascia following eccentric exercise : animal and human findings.2009

    • Author(s)
      Gibson W, Arent-Nielsen L, Taguchi T, Mizumura K, Graven-Nielsen T
    • Journal Title

      Exp Brain Res 194(2)

      Pages: 299-308

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Excitatory actions of mushroom poison (acromelic acid) on unmyelinated muscular afferents in the rat.2009

    • Author(s)
      Taguchi T, Tomotoshi K, Mizumura K
    • Journal Title

      Neurosci Lett 456(2)

      Pages: 69-73

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral mechanism of muscle pain : An update.2009

    • Author(s)
      Mizumura K
    • Journal Title

      Current Anaesthesia & Critical Care 20

      Pages: 183-7

    • Related Report
      2010 Final Research Report
  • [Journal Article] Changes in calcitonin gene-related peptide expression following joint immobilization in rats2009

    • Author(s)
      Nishigami T, 他
    • Journal Title

      Neurosci Lett 454(1)

      Pages: 97-100

    • NAID

      120002003634

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 運動器の不動化に伴う神経系の変化2009

    • Author(s)
      大迫洋治, 西上智彦, 他
    • Journal Title

      ペインクリニック 30(9)

      Pages: 1239-1248

    • Related Report
      2010 Final Research Report
  • [Journal Article] 両側変形性股関節症に対して片側人工股関節置換術を施行した症例の非術側に股関節牽引療法を行った効果について2009

    • Author(s)
      西上智彦, 若松志帆, 他
    • Journal Title

      理学療法科学 24(4)

      Pages: 613-615

    • NAID

      10025404459

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in calcitonin gene-related peptide expression following joint immobilization in rats2009

    • Author(s)
      Nishigami T, Osako Y, 他
    • Journal Title

      Neuroscience Letters. Vol.454 No.1

      Pages: 97-100

    • NAID

      120002003634

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ラット足関節不動化による活動制限は痛みを促進する2009

    • Author(s)
      山本綾, 肥田朋子, 他
    • Journal Title

      理学療法学 36(6)

      Pages: 305-311

    • NAID

      110007467994

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of muscle length on muscle atrophy in the mouse tibialis anterior and soleus muscles.2009

    • Author(s)
      Fujita N, Tasaki H, et al
    • Journal Title

      Biomedical Research 30(1)

      Pages: 39-45

    • NAID

      130004903747

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased pain sensitivity of muscle fascia following eccentric exercise : Animal and human findings.2009

    • Author(s)
      Gibson w, Mizumura K, et al
    • Journal Title

      Experimental Brain Research 194

      Pages: 299-308

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compression-induced ATP release from rat skeletal muscle with and without lengthening contraction.2008

    • Author(s)
      Taguchi T, Kozaki Y, Katanosaka K, Mizumura K
    • Journal Title

      Neurosci Lett 434(3)

      Pages: 277-281

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRP channels and ASICs mediate mechanical hyperalgesia in models of inflammatory muscle pain and delayed onset muscle soreness.2008

    • Author(s)
      Fujii Y, Mizumura K, 他
    • Journal Title

      Pain 140(2)

      Pages: 292-304

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 変形性膝関節症に対する理学療法とバイオメカニクス2008

    • Author(s)
      西上智彦, 奥埜博之, 中尾聡志, 芥川知彰, 榎勇人
    • Journal Title

      理学療法ジャーナル 42(10)

      Pages: 837-846

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral mechanism of muscle pain : An update

    • Author(s)
      Mizumura K
    • Journal Title

      Current Anaesthesia & Critical Care (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 運動器の10年セミナー痛みの基礎2010

    • Author(s)
      肥田朋子
    • Organizer
      第45回日本理学療法学術研修大会
    • Place of Presentation
      松山市
    • Year and Date
      2010-10-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Casting of ankle joint induces nociception in rats.2010

    • Author(s)
      Koeda T, Mizumura K, et al.
    • Organizer
      13th World Congress on Pain
    • Place of Presentation
      Palais de congres de Montreal (Montreal, Canada)
    • Year and Date
      2010-09-01
    • Related Report
      2010 Final Research Report
  • [Presentation] COX-2-GDNF pathway to delayed onset muscle soreness in rats.2010

    • Author(s)
      Murase S, Queme F, Taguchi T, Mizumura K
    • Organizer
      13th World Congress on Pain
    • Place of Presentation
      Palais de congres de Montreal (Montreal, Canada)
    • Year and Date
      2010-08-31
    • Related Report
      2010 Final Research Report
  • [Presentation] Casting of ankle joint induces nociception in rats2010

    • Author(s)
      Tomoko KOEDA
    • Organizer
      International association study of pain
    • Place of Presentation
      Montreal
    • Year and Date
      2010-08-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 変形性股関節症における局所痛と関連痛の関係について2010

    • Author(s)
      西上智彦
    • Organizer
      第32回日本疼痛学会
    • Place of Presentation
      京都市
    • Year and Date
      2010-07-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 関節の不動化は熱性痛覚過敏を生じさせるか?-行動学的評価および免疫組織化学的評価からの解析-2010

    • Author(s)
      西上智彦
    • Organizer
      第45回日本理学療法学術大会
    • Place of Presentation
      岐阜市
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] ギプス除去後は痛くて当然なのか?関節不動化による痛みに対する運動イメージの利用2010

    • Author(s)
      渡邉晃久
    • Organizer
      第45回日本理学療法学術大会
    • Place of Presentation
      岐阜市
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 筋硬度計による生体の硬さ測定2010

    • Author(s)
      天野幸代
    • Organizer
      第45回日本理学療法学術大会
    • Place of Presentation
      岐阜市
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 不動化に伴う疼痛発生に対する運動の影響~不動化モデルラットを用いて~2010

    • Author(s)
      肥田朋子, 他
    • Organizer
      第15回理学療法の医学的基礎研究会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-05-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 不動化に伴う疼痛発生に対する運動の影響-不動化モデルラットを用いて-2010

    • Author(s)
      肥田朋子
    • Organizer
      第15回理学療法の医学的基礎研究会学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 実例による理学療法体系化-基礎と臨床の架け橋-「慢性痛~新たな病気としての痛み~」痛みの解剖生理学2010

    • Author(s)
      肥田朋子
    • Organizer
      第15回理学療法の医学的基礎研究会学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 実例による理学療法体系化-基礎と臨床の架け橋-「慢性痛~新たな病気としての痛み~」慢性痛の中枢機構2010

    • Author(s)
      西上智彦
    • Organizer
      第15回理学療法の医学的基礎研究会学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 痛みに対する理学療法2010

    • Author(s)
      肥田朋子
    • Organizer
      愛知県理学療法学会
    • Place of Presentation
      愛知県産業労働センター(名古屋市)
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット足関節不動による痛みモデルの汎用性を求めて2008

    • Author(s)
      肥田朋子, 田崎洋光, 他
    • Organizer
      第12回 痛みを基礎から臨床まで考える会学術集会
    • Place of Presentation
      大阪府大東市
    • Year and Date
      2008-10-19
    • Related Report
      2008 Annual Research Report
  • [Book] 急性痛(沖田実他編)(機能障害科学入門)2010

    • Author(s)
      肥田朋子
    • Publisher
      神陵文庫(福岡)
    • Related Report
      2010 Final Research Report
  • [Book] 機能障害科学入門2010

    • Author(s)
      肥田朋子
    • Total Pages
      386
    • Publisher
      九州神陵文庫
    • Related Report
      2010 Annual Research Report
  • [Book] Facilitated response of muscle receptors after eccentric contraction.(Arandt-Nielsen L, Graven-Nielsen T, Mense S, eds.)(Fundamentals of Musculoskeletal Pain.)2008

    • Author(s)
      Mizumura K, Taguchi T.
    • Publisher
      IASP Press(Seattle)
    • Related Report
      2010 Final Research Report
  • [Book] 慢性疼痛の理解と医療連携(担当箇所 : 第4章 4理学療法士・作業療法士の立場から2008

    • Author(s)
      宮崎東洋, 北出利勝編肥田 朋子
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.maruron-ac.net/ngu-u/public/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.maruron-ac.net/ngu-u/public/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.ngu.jp/index.php

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.riem.nagoya-u.ac.jp

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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