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Experimental study on pain reduction mechanism of vertebroplasty for painful vertebral compression fracture

Research Project

Project/Area Number 20602010
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 疼痛学
Research InstitutionKansai Medical University

Principal Investigator

TANIGAWA Noboru  Kansai Medical University, 医学部, 准教授 (90227215)

Co-Investigator(Kenkyū-buntansha) SAWADA Satoshi  関西医科大学, 医学部, 教授 (80121937)
KARIYA Syuji  関西医科大学, 医学部, 講師 (40368220)
SHOMURA Yuzo  関西医科大学, 医学部, 助教 (70298868)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords疼痛学 / 圧迫骨折 / 椎体形成術
Research Abstract

In order to clarify the mechanism of the pain reduction of percutaneous vertebroplasty (Bone cement injection method) the animal experiments described below were performed. The vertebral compression fractures were made for the pigs, and three kinds of treatments were enforced to the compression fractures. That is, the cement injection, the bone punch formation, and the wire fixation were performed, and the difference of the therapeutic effect was observed. The bone punch formation group achieved only the effect equal with the treatment free group when judged from the result of obtaining from the image result and pig's breeding situation overall. Moreover, the metal wire treatment became equal to the bone cement treatment after the fourth day, though the initial therapeutic effect was excellent. Therefore, it turned out that the fixation with the wire or the bone cement more effective than the decompression of the vertebral body.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (6 results)

All 2010 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results)

  • [Journal Article] Cement leakage in percutaneous vertebroplasty for osteoporotic compression fracture with or without intravertebral clefts.2009

    • Author(s)
      Tanigawa N, Kariya S, Komemushi A, Tokuda T, Nakatani M, Yagi R, Sawada S
    • Journal Title

      Am J Roentgenol 193(5)

      Pages: 442-445

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cement leakage in percutaneous vertebroplasty for osteoporotic compression fracture with or without intravertebral clefts2009

    • Author(s)
      Tanigawa N, et al
    • Journal Title

      Am J Roentgenol 193

      Pages: 442-445

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement in respiratory function by percutaneous vertebroplasty.2008

    • Author(s)
      Tanigawa N, Kariya S, Kojima H, Komemushi A, Shomura Y, Tokuda T, Ueno Y, Kuwata S, Fujita A, Terada J, Sawada S
    • Journal Title

      Acta Radiologica 49(6)

      Pages: 638-643

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Prospective analysis of respiratory function following percutaneous vertebroplasty for osteoporotic compression fractures2010

    • Author(s)
      Tanigawa N, et al
    • Organizer
      35th Annual Scientific Meeting of The Society of International Radiology
    • Place of Presentation
      Tampa, FL, USA
    • Year and Date
      2010-03-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Prospective analysis of respiratory function following percutaneous vertebroplasty for osteoporotic compression fractures.2010

    • Author(s)
      Tanigawa N, et al
    • Organizer
      35nd Annual Scientific Meeting of The Society of International Radiology
    • Place of Presentation
      Tampa, FL, U.S.A.
    • Related Report
      2010 Final Research Report
  • [Presentation] Percutaneous vertebroplasty for osteoporotic compression fracture, First 500 levels of a single center : Long term evaluation of the technical and clinical outcomes.2009

    • Author(s)
      Tanigawa N, et al
    • Organizer
      34nd Annual Scientific Meeting of The Society of International Radiology
    • Place of Presentation
      San Diego, CA, U.S.A.
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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