Experimental study on pain reduction mechanism of vertebroplasty for painful vertebral compression fracture

• Project/Area Number: 20602010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 疼痛学
• Research Institution: Kansai Medical University
• Principal Investigator: TANIGAWA Noboru Kansai Medical University, 医学部, 准教授 (90227215)
• Co-Investigator(Kenkyū-buntansha): SAWADA Satoshi 関西医科大学, 医学部, 教授 (80121937) ; KARIYA Syuji 関西医科大学, 医学部, 講師 (40368220) ; SHOMURA Yuzo 関西医科大学, 医学部, 助教 (70298868)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 疼痛学 / 圧迫骨折 / 椎体形成術

Research Abstract

In order to clarify the mechanism of the pain reduction of percutaneous vertebroplasty (Bone cement injection method) the animal experiments described below were performed. The vertebral compression fractures were made for the pigs, and three kinds of treatments were enforced to the compression fractures. That is, the cement injection, the bone punch formation, and the wire fixation were performed, and the difference of the therapeutic effect was observed. The bone punch formation group achieved only the effect equal with the treatment free group when judged from the result of obtaining from the image result and pig's breeding situation overall. Moreover, the metal wire treatment became equal to the bone cement treatment after the fourth day, though the initial therapeutic effect was excellent. Therefore, it turned out that the fixation with the wire or the bone cement more effective than the decompression of the vertebral body.

Research Products

• [Journal Article] Cement leakage in percutaneous vertebroplasty for osteoporotic compression fracture with or without intravertebral clefts. (2009)
  • Author(s): Tanigawa N, Kariya S, Komemushi A, Tokuda T, Nakatani M, Yagi R, Sawada S
  • Journal Title: Am J Roentgenol 193(5) Pages: 442-445
  • Peer Reviewed
• [Journal Article] Cement leakage in percutaneous vertebroplasty for osteoporotic compression fracture with or without intravertebral clefts (2009)
  • Author(s): Tanigawa N, et al
  • Journal Title: Am J Roentgenol 193 Pages: 442-445
  • Peer Reviewed
• [Journal Article] Improvement in respiratory function by percutaneous vertebroplasty. (2008)
  • Author(s): Tanigawa N, Kariya S, Kojima H, Komemushi A, Shomura Y, Tokuda T, Ueno Y, Kuwata S, Fujita A, Terada J, Sawada S
  • Journal Title: Acta Radiologica 49(6) Pages: 638-643
  • Peer Reviewed
• [Presentation] Prospective analysis of respiratory function following percutaneous vertebroplasty for osteoporotic compression fractures (2010)
  • Author(s): Tanigawa N, et al
  • Organizer: 35th Annual Scientific Meeting of The Society of International Radiology
  • Place of Presentation: Tampa, FL, USA
  • Year and Date: 2010-03-14
• [Presentation] Prospective analysis of respiratory function following percutaneous vertebroplasty for osteoporotic compression fractures. (2010)
  • Author(s): Tanigawa N, et al
  • Organizer: 35nd Annual Scientific Meeting of The Society of International Radiology
  • Place of Presentation: Tampa, FL, U.S.A.
• [Presentation] Percutaneous vertebroplasty for osteoporotic compression fracture, First 500 levels of a single center : Long term evaluation of the technical and clinical outcomes. (2009)
  • Author(s): Tanigawa N, et al
  • Organizer: 34nd Annual Scientific Meeting of The Society of International Radiology
  • Place of Presentation: San Diego, CA, U.S.A.