| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The neuropeptide nocistatin has inhibitory effects on chronic pain after nerve injury and inflammation. We identified a protein (Nocistatin binding protein, NSP) that interacted with nocistatin from synaptosomal membranes of mouse spinal cord. Nocistatin interacted with the N-terminal truncated form of 29-kDa NSP that was ubiquitously expressed in neural tissues. The inhibition of tactile allodynia by nocistatin seen in wild-type mice was completely lacking in NSP-deficient mice, and the inflammatory pain was prolonged in the deficient mice.
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