Proteomic analysis for mechanisms of neuropathic pain
Project/Area Number |
20602015
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
疼痛学
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Research Institution | Kansai Medical University |
Principal Investigator |
KATANO Tayo Kansai Medical University, 医学部, 助教 (60469244)
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Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Shinji 関西医科大学, 医学部, 講師 (70276393)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | NR2B / プロテオミクス / リン酸化 / 神経因性疼痛 / CaMKII / SNIモデル / NMDA受容体 / AMPA受容体 / GluR1 |
Research Abstract |
Chronic pain is maintained by plastic change to synapse in the spinal dorsal horn. We previously clarified that the phosphorylation of Y1472 NR2B is important for neuropathic pain. In the present study, we determined the phosphorylation cascade through activation of CaMKII and identified two molecules as changing volume of protein after SNI in the postsynaptic density fraction by proteomic analysis using Y1472F KI mice, which have a knock-in mutation of the Tyr1472 site to phenylalanine, as comparison subject.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation.2008
Author(s)
Takagi K., Okuda-Ashitaka E., Mabuchi T., Katano T., Ohnishi T., Matsumura S., Ohnaka M., Kaneko S., Abe T., Hirata T., Fujiwara S., Minami T., Ito S.
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Journal Title
Neuroscience 153
Pages: 1278-1288
Related Report
Peer Reviewed
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