Involvement of the gasotransmitter hydrogen sulfide in neurogenic pain
| Project/Area Number |
20602016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Kinki University |
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Principal Investigator |
KAWABATA Atsufumi Kinki University, 薬学部, 教授 (20177728)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Shigeru 近畿大学, 理工学部, 教授 (60145224)
SEKIGUCHI Fumiko 近畿大学, 薬学部, 准教授 (90271410)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ニューロパチー / 神経障害性疼痛 / 生体内ガス / 硫化水素 / T型カルシウムチャネル / 痛み / 神経因性疼痛 / siRNA / T型Ca^<2+>チャネル |
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| Research Abstract |
We first demonstrated the involvement of Cav3.2 T-type calcium channels in hydrogen sulfide-induced facilitation of nociception. We then found that, in rats with L5 spinal nerve injury, the activation of Cav3.2 by endogenous hydrogen sulfide was involved in the maintenance of hyperalgesia/allodynia, and Cav3.2 was upregulated, suggesting that the hydrogen sulfide/Cav3.2 pathway should be a therapeutic target for treatment of neurogenic pain.
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Report
(4 results)
Research Products
(33 results)
