Analysis of mechanism of lumber pain that focused in pain sensor such as TRP channels.

• Project/Area Number: 20602019
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 疼痛学
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: YOKOYAMA Toru University of Occupational and Environmental Health, Japan, 医学部, 助教 (80425321)
• Co-Investigator(Kenkyū-buntansha): MINAMI Kouichiro 自治医科大学, 医学部, 講師 (70279347) ; UETA Yoichi 産業医科大学, 医学部, 教授 (10232745) ; 岡本 隆史 産業医科大学, 医学部, 非常勤助教 (60446119)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 疼痛 / TRP / チャネル / 鎮痛 / 脳神経 / 電気生理学 / カルシウム

Research Abstract

We demonstrated pain sensor TRPV1 is essential for osmo-regulation in central nerves systems. TRPA1 agonists potentiate excitatory synaptic inputs to the SON. We found the possibility that vasopressin strongly participated in a pain.

Research Products

• [Journal Article] Allyl isothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the supraoptic nucleus in rats. (2011)
  • Author(s): Yokoyama T, Ohbuchi T, Saito T, Sudo Y, Fujihara H, Minami K, Nagatomo T, Ueta Y.
  • Journal Title: European Journal of Pharmacology 655 Pages: 31-37
  • Peer Reviewed
• [Journal Article] The tramadol metabolite o-desmethyl tramadol inhibits substance p-receptor functions expressed in Xenopus oocytes. (2011)
  • Author(s): Minami K, Yokoyama T, Ogata J, Uezono Y.
  • Journal Title: Journal of Pharmacological Sciences 115 Pages: 421-424
  • NAID: 10029892983
  • Peer Reviewed
• [Journal Article] Effects of Sevoflurane on Voltage-gated Sodium Channel Nav1.8, Nav1.7 and Nav1.4 Expressed in Xenopus Oocytes. (2011)
  • Author(s): Yokoyama T, Minami K, Sudo Y, Horishita T, Ogata J, Yanagita T, Takeuchi M, Uezono Y.
  • Journal Title: Journal of Anesthesia in press
  • Peer Reviewed
• [Journal Article] Allyl isothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the supraoptic nucleus in rats (2011)
  • Author(s): Yokoyama T
  • Journal Title: European Journal of Pharmacology Volume: 655 Pages: 31-37
  • Peer Reviewed
• [Journal Article] The tramadol metabolite o-desmethyl tramadol inhibits substance p-receptor functions expressed in Xenopus oocytes. (2011)
  • Author(s): Minami K, Yokoyama T
  • Journal Title: Journal of Pharmacological Sciences Volume: 115 Pages: 421-424
  • NAID: 10029892983
  • Peer Reviewed
• [Journal Article] TRPV1 gene deficiency attenuates miniature EPSC potentiation induced by mannitol and angiotensin II in the supraoptic magnocellular neurons. (2010)
  • Author(s): Yokoyama T, Saito T, Ohbuchi T, Hashimoto H, Suzuki H, Otsubo H, Fujihara H, Nagatomo T, Ueta Y.
  • Journal Title: Journal of Neuroscience 30(3) Pages: 876-884
  • Peer Reviewed
• [Journal Article] TRPV1 gene deficiency attenuates miniature EPSC potentiation induced by mannitol and angiotensin II in the supraoptic magnocellular neurons (2010)
  • Author(s): Yokoyama T, Saito T, Ohbuchi T, Hashimoto H, Suzuki H, Otsubo H, Fujihara H, Nagatomo T, Ueta Y
  • Journal Title: Journal of Neuroscience 30(3) Pages: 876-884
  • Peer Reviewed
• [Journal Article] Ghrelin potentiates miniature excitatory postsynaptic currents in supraoptic magnocellular neurones. (2009)
  • Author(s): Yokoyama T, Saito T, Ohbuchi T, Suzuki H, Otsubo H, Okamoto T, Fujihara H, Nagatomo T, Ueta Y.
  • Journal Title: Journal of Neuroendocrinology 21(11) Pages: 910-920
  • Peer Reviewed
• [Journal Article] Exaggerated response of a vasopressin -enhansed green fluorescent protein transgene to nociceptive stimulation in the rat. (2009)
  • Author(s): Suzuki H, Kawasaki M, Ohnishi H, Ohbuchi T, Katoh A, Hashimoto H, Yokoyama T, Fujihara H, Dayanithi G, Murphy D, Nakamura T, Ueta Y.
  • Journal Title: Journal of Neuroscience 29(42) Pages: 13182-13189
  • Peer Reviewed
• [Journal Article] Ghrelin potentiates miniature excitatory postsynaptic currents in supraoptic magnocellular neurones (2009)
  • Author(s): Yokoyama T, Saito T, Ohbuchi, Suzuki H, Otsubo H, Okamoto T, Fujihara H, Nagatomo T, Ueta Y
  • Journal Title: Journal of Neuroendocrinology 21(11) Pages: 910-920
  • Peer Reviewed
• [Presentation] ラット視索上核大細胞神経分泌ニューロンへの興奮性シナプス入力に対するTRPA1アゴニストの効果 (2011)
  • Author(s): 横山徹、大淵豊明、斎藤健、藤原広明、長友敏寿、上田陽一
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-03-29
• [Presentation] 視索上核大細胞性神経分泌ニューロンへの興奮性シナプス入力に対するグレリンの効果はTRPV1によって調節される (2010)
  • Author(s): 横山徹、大淵豊明、上田陽一
  • Organizer: 第20回日本病態生理学会大会
  • Place of Presentation: 奈良
  • Year and Date: 2010-01-24
• [Presentation] 視索上核大細胞性神経分泌細胞の浸透圧感受性におけるTRPV1の関与 (2009)
  • Author(s): 横山徹、大淵豊明、長友敏寿、上田陽一
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-09-18
• [Presentation] ラット視索上核大細胞性神経分泌ニューロンへのシナプス入力におけるTRPA1の役割 : 電気生理学的検討 (2008)
  • Author(s): 横山徹, 大渕豊明, 藤原広明, 長友敏寿, 上田陽一
  • Organizer: 第59回西日本生理学会
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-03
• [Presentation] Pain sensor TRPV1 facilities excitatory synaptic inputs to the magnocellular neurons in the supraoptic nucleus of rat. (2008)
  • Author(s): Yokoyama T, Minami K, Okamoto T, Ueta Y
  • Organizer: The 3rd Asian Pain Symposium.
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-19
• [Presentation] ラット視索上核大細胞性神経分泌ニューロンへの興奮性シナプス入力に対するアンジオテンシンIIおよびグレリンの影響 (2008)
  • Author(s): 横山徹、齋藤健、大淵豊明、橋本弘史、鈴木仁士、大坪広樹、上田陽一
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 青森市
  • Year and Date: 2008-05-17
• [Presentation] Pain sensor TRPV1 facilities excitatory synaptic inputs to the magnocellular neurons in the supraoptic nucleus of rat. (2008)
  • Author(s): Yokoyama T, Minami K, Okamoto T, Ueta Y.
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
• [Book] 脳とホルモンの行動学(近藤保彦、小川園子他 編) (2010)
  • Author(s): 横山徹
  • Publisher: 西村書店