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Analysis of mechanism of lumber pain that focused in pain sensor such as TRP channels.

Research Project

Project/Area Number 20602019
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 疼痛学
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

YOKOYAMA Toru  University of Occupational and Environmental Health, Japan, 医学部, 助教 (80425321)

Co-Investigator(Kenkyū-buntansha) MINAMI Kouichiro  自治医科大学, 医学部, 講師 (70279347)
UETA Yoichi  産業医科大学, 医学部, 教授 (10232745)
岡本 隆史  産業医科大学, 医学部, 非常勤助教 (60446119)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords疼痛 / TRP / チャネル / 鎮痛 / 脳神経 / 電気生理学 / カルシウム
Research Abstract

We demonstrated pain sensor TRPV1 is essential for osmo-regulation in central nerves systems. TRPA1 agonists potentiate excitatory synaptic inputs to the SON. We found the possibility that vasopressin strongly participated in a pain.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (18 results)

All 2011 2010 2009 2008

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (7 results) Book (1 results)

  • [Journal Article] Allyl isothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the supraoptic nucleus in rats.2011

    • Author(s)
      Yokoyama T, Ohbuchi T, Saito T, Sudo Y, Fujihara H, Minami K, Nagatomo T, Ueta Y.
    • Journal Title

      European Journal of Pharmacology 655

      Pages: 31-37

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The tramadol metabolite o-desmethyl tramadol inhibits substance p-receptor functions expressed in Xenopus oocytes.2011

    • Author(s)
      Minami K, Yokoyama T, Ogata J, Uezono Y.
    • Journal Title

      Journal of Pharmacological Sciences 115

      Pages: 421-424

    • NAID

      10029892983

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Sevoflurane on Voltage-gated Sodium Channel Nav1.8, Nav1.7 and Nav1.4 Expressed in Xenopus Oocytes.2011

    • Author(s)
      Yokoyama T, Minami K, Sudo Y, Horishita T, Ogata J, Yanagita T, Takeuchi M, Uezono Y.
    • Journal Title

      Journal of Anesthesia in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Allyl isothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the supraoptic nucleus in rats2011

    • Author(s)
      Yokoyama T
    • Journal Title

      European Journal of Pharmacology

      Volume: 655 Pages: 31-37

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The tramadol metabolite o-desmethyl tramadol inhibits substance p-receptor functions expressed in Xenopus oocytes.2011

    • Author(s)
      Minami K, Yokoyama T
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 115 Pages: 421-424

    • NAID

      10029892983

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRPV1 gene deficiency attenuates miniature EPSC potentiation induced by mannitol and angiotensin II in the supraoptic magnocellular neurons.2010

    • Author(s)
      Yokoyama T, Saito T, Ohbuchi T, Hashimoto H, Suzuki H, Otsubo H, Fujihara H, Nagatomo T, Ueta Y.
    • Journal Title

      Journal of Neuroscience 30(3)

      Pages: 876-884

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPV1 gene deficiency attenuates miniature EPSC potentiation induced by mannitol and angiotensin II in the supraoptic magnocellular neurons2010

    • Author(s)
      Yokoyama T, Saito T, Ohbuchi T, Hashimoto H, Suzuki H, Otsubo H, Fujihara H, Nagatomo T, Ueta Y
    • Journal Title

      Journal of Neuroscience 30(3)

      Pages: 876-884

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin potentiates miniature excitatory postsynaptic currents in supraoptic magnocellular neurones.2009

    • Author(s)
      Yokoyama T, Saito T, Ohbuchi T, Suzuki H, Otsubo H, Okamoto T, Fujihara H, Nagatomo T, Ueta Y.
    • Journal Title

      Journal of Neuroendocrinology 21(11)

      Pages: 910-920

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exaggerated response of a vasopressin -enhansed green fluorescent protein transgene to nociceptive stimulation in the rat.2009

    • Author(s)
      Suzuki H, Kawasaki M, Ohnishi H, Ohbuchi T, Katoh A, Hashimoto H, Yokoyama T, Fujihara H, Dayanithi G, Murphy D, Nakamura T, Ueta Y.
    • Journal Title

      Journal of Neuroscience 29(42)

      Pages: 13182-13189

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin potentiates miniature excitatory postsynaptic currents in supraoptic magnocellular neurones2009

    • Author(s)
      Yokoyama T, Saito T, Ohbuchi, Suzuki H, Otsubo H, Okamoto T, Fujihara H, Nagatomo T, Ueta Y
    • Journal Title

      Journal of Neuroendocrinology 21(11)

      Pages: 910-920

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラット視索上核大細胞神経分泌ニューロンへの興奮性シナプス入力に対するTRPA1アゴニストの効果2011

    • Author(s)
      横山徹、大淵豊明、斎藤健、藤原広明、長友敏寿、上田陽一
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 視索上核大細胞性神経分泌ニューロンへの興奮性シナプス入力に対するグレリンの効果はTRPV1によって調節される2010

    • Author(s)
      横山徹、大淵豊明、上田陽一
    • Organizer
      第20回日本病態生理学会大会
    • Place of Presentation
      奈良
    • Year and Date
      2010-01-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 視索上核大細胞性神経分泌細胞の浸透圧感受性におけるTRPV1の関与2009

    • Author(s)
      横山徹、大淵豊明、長友敏寿、上田陽一
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ラット視索上核大細胞性神経分泌ニューロンへのシナプス入力におけるTRPA1の役割 : 電気生理学的検討2008

    • Author(s)
      横山徹, 大渕豊明, 藤原広明, 長友敏寿, 上田陽一
    • Organizer
      第59回西日本生理学会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pain sensor TRPV1 facilities excitatory synaptic inputs to the magnocellular neurons in the supraoptic nucleus of rat.2008

    • Author(s)
      Yokoyama T, Minami K, Okamoto T, Ueta Y
    • Organizer
      The 3rd Asian Pain Symposium.
    • Place of Presentation
      Fukuoka
    • Year and Date
      2008-07-19
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット視索上核大細胞性神経分泌ニューロンへの興奮性シナプス入力に対するアンジオテンシンIIおよびグレリンの影響2008

    • Author(s)
      横山徹、齋藤健、大淵豊明、橋本弘史、鈴木仁士、大坪広樹、上田陽一
    • Organizer
      第81回日本内分泌学会学術総会
    • Place of Presentation
      青森市
    • Year and Date
      2008-05-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Pain sensor TRPV1 facilities excitatory synaptic inputs to the magnocellular neurons in the supraoptic nucleus of rat.2008

    • Author(s)
      Yokoyama T, Minami K, Okamoto T, Ueta Y.
    • Organizer
      The 3rd Asian Pain Symposium
    • Place of Presentation
      Fukuoka
    • Related Report
      2008 Annual Research Report
  • [Book] 脳とホルモンの行動学(近藤保彦、小川園子他 編)2010

    • Author(s)
      横山徹
    • Publisher
      西村書店
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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