Study on molecular mechanism of oxidative stress in brain and anti-oxidant interventions
| Project/Area Number |
20608005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
光生命科学
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2009-2011)
Tokyo Metropolitan Institute of Gerontology (2008) |
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Principal Investigator |
SASAKI Toru 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 主任研究員 (30158927)
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| Co-Investigator(Kenkyū-buntansha) |
NARIAI Tadashi 東京医科歯科大学, 医学部付属病院, 講師 (00228090)
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| Co-Investigator(Renkei-kenkyūsha) |
TAHARA Shoichi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (70250199)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 酸化ストレス / 分子イメージング / 脳 / 老化 / 活性酸素 / 虚血 / 化学発光 / 寿命 |
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| Research Abstract |
We examined reactive oxygen radical-dependent chemiluminescent signals in ex-vivo brain slices using a novel photonic imaging method "real-time bioradiography". Results are as follows.(1) Reactive oxygen radical generation and glucose metabolism was enhanced during hypoxia-reoxygenation and hypoxia, respectively.(2) Mitochondria are suggested as major sites of reactive oxygen radical generation.(3) To develop the interventions to decelerate oxidative stress, we examined effect of calorie restriction on reactive oxygen radical generation. However, calorie restriction did not change the reactive oxygen radical generation.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Active component in green tea catechins and effective intake period for prevention of age-related brain dysfunction2011
Author(s)
Unno K, Yamamoto H, Ohtaki T, Ishikawa Y, Noda S, Maeda K, Fujitani K, Miyazaki H, Takabayashi F, Sasaki T, Hoshino M
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Journal Title
Anti-Aging Medicine
Volume: 8(6)
Pages: 75-81
URL
Related Report
Peer Reviewed
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[Journal Article] Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice2008
Author(s)
Kondo Y, SasakiT, Sato Y, Amano A, Aizawa S, Iwama M, Handa S, Shimada N, Fukuda M, Akita M, Lee J, Jeong K, Maruyama N
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Journal Title
Biochem Biophys Res Commun
Volume: 377(1)
Pages: 291-296
URL
Related Report
Peer Reviewed
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[Journal Article] Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice2008
Author(s)
Sato Y, Kajiyama S, Amano A, Kondo Y, Sasaki T, Handa S, Takahashi R, Fukui M, Hasegawa G, Nakamura N, Fujinawa H, Mori T, Ohta M, Obayashi H, Maruyama N, Ishigami A
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Journal Title
Biochem Biophys Res Commun
Volume: 375(3)
Pages: 346-350
URL
Related Report
Peer Reviewed
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