Establishment of iPS cell transplantation that does not form teratomas

• Project/Area Number: 20610006
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Stem cell biology and medical science
• Research Institution: Keio University
• Principal Investigator: AKAMATSU Wado Keio University, 医学部, 講師 (60338184)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: iPS細胞 / 神経幹細胞 / ES細胞 / 神経分化 / 万能性 / 腫瘍化能

Research Abstract

We have succeeded in generating neural stem cells from mouse fibroblasts by using gene transfer. These neural stem cells are mature and contain few residual pluripotent cells.

Research Products

• [Journal Article] Generation of human melanocytes from induced pluripotent stem cells. (2011)
  • Author(s): Ohta S, Imaizumi Y, Okada Y, Akamatsu W, Kuwahara R, Ohyama M, Amagai M, Matsuzaki Y, Yamanaka S, Okano H, Kawakami Y.
  • Journal Title: PLoS One. 6(1)
  • Peer Reviewed
• [Journal Article] Generation of Human Melanocytes from Induced Pluripotent Stem Cells (2011)
  • Author(s): Ohta, et al.
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Journal Article] Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage. (2009)
  • Author(s): Akamatsu W, DeVeale B, Okano H, Cooney AJ, van der Kooy D.
  • Journal Title: J Neurosci. 29(7) Pages: 2113-24
  • Peer Reviewed
• [Journal Article] Suppression of 0ct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage. (2009)
  • Author(s): Akamatsu W, DeVeale B, 0kano H, Cooney AJ, van der Kooy D.
  • Journal Title: The Journal of Neuroscience 29(7) Pages: 2113-2124
  • Peer Reviewed
• [Presentation] Generation of human iPS-derived melanocytes in vitro (2009)
  • Author(s): Shigeki Ohta, Wado Akamatsu, Yohei Okada, Yumi Matsuzaki, Hideyuki Okano, Yutaka Kawakami
  • Organizer: 2009年度日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] 孤発性筋萎縮性側索側策硬化症患者からのiPS細胞樹立 (2009)
  • Author(s): 二瓶義廣
  • Organizer: 第28回日本認知症学会学術総会
  • Place of Presentation: 仙台
• [Presentation] Molecular profiling of schizophrenia by use of patient-derived olfactory neurons and induced pluripotent stem (iPS) cells (2009)
  • Author(s): S.-I. KANO
  • Organizer: 北米神経科学会年会2009
  • Place of Presentation: シカゴ
• [Presentation] RETROVIRUS/LENTIVIRUS INTEGRATION SITE ANALYSIS OF HUMAN INDUCED PLURIPOTENT STEM (iPS) CELLS (2009)
  • Author(s): Yoshikazu Sugimoto
  • Organizer: 第15回日本遺伝子治療学会
  • Place of Presentation: 大阪
• [Presentation] 岡野栄之再生医療の現状と将来の見通し (2009)
  • Author(s): 赤松和土
  • Organizer: 第35回BMSコンファレンス基調講演
  • Place of Presentation: 高知
• [Presentation] 孤発性パーキンソン病患者からのiPS細胞の樹立 (2009)
  • Author(s): 八木拓也
  • Organizer: 第50回日本神経学会
  • Place of Presentation: 仙台
• [Presentation] GCNF/Oct4シグナルによる初期神経幹細胞の分化誘導と万能性の抑制 (2008)
  • Author(s): 赤松和土, DeVeale B,岡野栄之,Cooney AJ, van der Kooy D
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Patent(Industrial Property Rights)] 神経幹細胞製造法 (2009)
  • Inventor(s): 赤松和土
  • Industrial Property Rights Holder: 岡野栄之
  • Filing Date: 2009-11-04
  • Overseas