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Establishment of iPS cell transplantation that does not form teratomas

Research Project

Project/Area Number 20610006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Stem cell biology and medical science
Research InstitutionKeio University

Principal Investigator

AKAMATSU Wado  Keio University, 医学部, 講師 (60338184)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsiPS細胞 / 神経幹細胞 / ES細胞 / 神経分化 / 万能性 / 腫瘍化能
Research Abstract

We have succeeded in generating neural stem cells from mouse fibroblasts by using gene transfer. These neural stem cells are mature and contain few residual pluripotent cells.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (12 results)

All 2011 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (7 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Generation of human melanocytes from induced pluripotent stem cells.2011

    • Author(s)
      Ohta S, Imaizumi Y, Okada Y, Akamatsu W, Kuwahara R, Ohyama M, Amagai M, Matsuzaki Y, Yamanaka S, Okano H, Kawakami Y.
    • Journal Title

      PLoS One. 6(1)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generation of Human Melanocytes from Induced Pluripotent Stem Cells2011

    • Author(s)
      Ohta, et al.
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage.2009

    • Author(s)
      Akamatsu W, DeVeale B, Okano H, Cooney AJ, van der Kooy D.
    • Journal Title

      J Neurosci. 29(7)

      Pages: 2113-24

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of 0ct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage.2009

    • Author(s)
      Akamatsu W, DeVeale B, 0kano H, Cooney AJ, van der Kooy D.
    • Journal Title

      The Journal of Neuroscience 29(7)

      Pages: 2113-2124

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Generation of human iPS-derived melanocytes in vitro2009

    • Author(s)
      Shigeki Ohta, Wado Akamatsu, Yohei Okada, Yumi Matsuzaki, Hideyuki Okano, Yutaka Kawakami
    • Organizer
      2009年度日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] 孤発性筋萎縮性側索側策硬化症患者からのiPS細胞樹立2009

    • Author(s)
      二瓶義廣
    • Organizer
      第28回日本認知症学会学術総会
    • Place of Presentation
      仙台
    • Related Report
      2010 Final Research Report
  • [Presentation] Molecular profiling of schizophrenia by use of patient-derived olfactory neurons and induced pluripotent stem (iPS) cells2009

    • Author(s)
      S.-I. KANO
    • Organizer
      北米神経科学会年会2009
    • Place of Presentation
      シカゴ
    • Related Report
      2010 Final Research Report
  • [Presentation] RETROVIRUS/LENTIVIRUS INTEGRATION SITE ANALYSIS OF HUMAN INDUCED PLURIPOTENT STEM (iPS) CELLS2009

    • Author(s)
      Yoshikazu Sugimoto
    • Organizer
      第15回日本遺伝子治療学会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 岡野栄之再生医療の現状と将来の見通し2009

    • Author(s)
      赤松和土
    • Organizer
      第35回BMSコンファレンス基調講演
    • Place of Presentation
      高知
    • Related Report
      2010 Final Research Report
  • [Presentation] 孤発性パーキンソン病患者からのiPS細胞の樹立2009

    • Author(s)
      八木拓也
    • Organizer
      第50回日本神経学会
    • Place of Presentation
      仙台
    • Related Report
      2010 Final Research Report
  • [Presentation] GCNF/Oct4シグナルによる初期神経幹細胞の分化誘導と万能性の抑制2008

    • Author(s)
      赤松和土, DeVeale B,岡野栄之,Cooney AJ, van der Kooy D
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 神経幹細胞製造法2009

    • Inventor(s)
      赤松和土
    • Industrial Property Rights Holder
      岡野栄之
    • Filing Date
      2009-11-04
    • Related Report
      2009 Annual Research Report
    • Overseas

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Published: 2008-04-01   Modified: 2016-04-21  

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