Regulatory mechanism of ES cells by a novel chromatin-related factor and its application to the reprogramming method of somatic cells.
| Project/Area Number |
20610008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Stem cell biology and medical science
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
KURISAKI Akira National Institute of Advanced Industrial Science and Technology, 幹細胞工学研究センター, 研究チーム長 (60346616)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 幹細胞 / クロマチン / プロテオミクス / ES細胞 / iPS細胞 / 分化 / 転写因子 / リン酸化 / TIF1β / 多能性 / ヒストン / 脱分化 |
|---|
| Research Abstract |
Although hyperdynamic chromatin is a hallmark of pluripotent stem cells, the mechanisms that regulate these conditions of chromatin were poorly understood. In this study, we found that phosphorylated form of TIF1β is a critical molecule for the maintenance of pluripotency of ES cells. Moreover, phosphorylated form of TIF1β is effective to establish better quality of iPS cells.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article]2009
Author(s)
栗崎晃, 浅島誠
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Journal Title
幹細胞の標準化へのアプローチ(iPS細胞の産業的応用技術)(CMC出版)
Pages: 26-33
Related Report
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