Roles of long chain polyol compounds in symbiotic functions of microalgae
| Project/Area Number |
20611006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Nagoya University |
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Principal Investigator |
OHNO Osamu Nagoya University, 理工学部, 助教 (20436992)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 天然物有機化学 / 生物活性天然物 / ポリオール / ケミカルバイオロジー / 共生 / ポリオール化合物 / 微細藻類 / 生物活性 / シンビオスピロール / 藍藻 / シンビオジノライド |
|---|
| Research Abstract |
While long chain polyol compounds have been reported to show various biological activities, their biological functions and roles in symbioses have not been thoroughly investigated. In this project, we aimed to obtain novel long chain polyol compounds from symbiotic microalgae and to understand their structures and functions in symbiotic relationships. As a result, we succeeded to find several novel long chain polyol compounds, such as symbiospirols, and their unique characteristics were identified. We prepared polyclonal anti-bodies against symbiospirol A and tried to detect its localization in the producer organisms by microscopic analyses.
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Report
(4 results)
Research Products
(76 results)
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[Journal Article] Inhibitory Effects of Bakuchiol, Bavachin and Isobavachalcone Isolated from Piper longum on Melanin Production in B16 Mouse Melanoma Cells2010
Author(s)
Ohno O., Watabe T., Nakamura K., Kawagoshi M., Uotsu N., Chiba T., Yamada M., Yamaguchi K., Yamada K., Miyamoto K., Uemura, D.
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Journal Title
Bioscience, Biotechnology, and Biochemistry 74
Pages: 1504-1506
NAID
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Peer Reviewed
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[Journal Article] Inhibitory Effects of Benzyl Benzoate and Its Derivatives on Angiotensin II-Induced Hypertension2008
Author(s)
Ohno O., Ye M., Koyama T., Yazawa K., Mura E., Matsumoto H., Ichino T., Yamada K., Nakamura K., Ohno T., Yamaguchi K., Ishida J., Fukamizu A., Uemura D.
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Journal Title
Bioorganic & Medicinal Chemistry 16
Pages: 7843-7852
Related Report
Peer Reviewed
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[Presentation] Inhibitory effects of prenylated phenolic compounds isolated from Piper longum on melanin biosynthesis in B16 cells2010
Author(s)
Ohno O., Watabe T., Nakamura K., Kawagoshi M., Uotsu N., Chiba T., Yamada M., Yamaguchi K., Yamada K., Uemura D.
Organizer
Pacifichem 2010 conference
Place of Presentation
Hawaii, USA
Year and Date
2010-12-19
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[Presentation] Inhibitory Effects of Benzyl Benzoate Derivatives against the Activity of Angiotensin II.2009
Author(s)
Ohno O., Nakamura K., Watabe T., Persson A., Yamada K., Fujiwara C., Koyama T., Yazawa K., Ohno T., Yamaguchi K., Uemura D.
Organizer
The 50th Anniversary Meeting of the American Society of Pharmacognosy (ASP)
Place of Presentation
Hawaii, USA
Year and Date
2009-06-28
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