The chemical biology of low side effects compound in anti-fever drugs, which is derived from the analysis about fatal function by diclofenac.
| Project/Area Number |
20611013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YANO Mihiro (2010) The University of Tokushima, 疾患酵素学研究センター, 准教授 (40304555)
ユースフ シセ (2008-2009) The University of Tokushima, 疾患酵素学研究センター, 科学技術振興研究員 (80437649)
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| Co-Investigator(Kenkyū-buntansha) |
KIDO Hiroshi 徳島大学, 疾患酵素学研究センター, 教授 (50144978)
矢野 仁康 徳島大学, 疾患酵素学研究センター, 准教授 (40304555)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | インフルエンザウイルス / ジクロフェナクナトリウム / ウイルス放出障害 / インフルエンザ脳症 / 解熱剤 / ジクロフェナック / ウイルス放出阻害 / Caチャネルブロッカー / Naチャネルブロッカー / ライ症候群 |
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| Research Abstract |
To clarify the mechanisms of influenza encephalitis induced by diclofenac, we examined the effect of influenza virus and diclofenac on the disruption of tight junction (TJ) in human vascular endothelial cells in vitro. In this study, we found that influenza virus induced the degradation of TJ proteins, such as ZO1, leading to its disruption. On the other hands, diclofenac by itself inhibited the synthesis of TJ proteins, consequently accelerating the disruption of TJ induced by influenza infection in vascular endothelial cells.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Novel Type II Transmembrane Serine Proteases, MSPL and TMPRSS 13, Proteolytically Activate Membrane Fusion Activity of the Hemagglutinin of Highly Pathogenic Avian Influenza Viruses and Induce Their Multicycle Replication.2010
Author(s)
Y Okumura, E Takahashi, M Yano, M Ohuchi, T Daidoji, T Nakaya, W Gaten, HD Klenk, H Kido.
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Journal Title
Journal of Virology 84,10
Pages: 5089-5096
Related Report
Peer Reviewed
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[Journal Article] Influenza vaccine with Surfacten, a modified pulmonary surfactant, induces systemic and mucosal immune responses without side effects in minipigs.2009
Author(s)
Nishino M, Mizuno D, Kimoto T, Shinahara W, Fukuta A, Takei T, Sumida K, Kitamura S, Shiota H, Kido H.
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Journal Title
Vacctine. 18;27(41)
Pages: 5620-5627
Related Report
Peer Reviewed
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