| Project/Area Number |
20611014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical biology
|
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| Research Institution | Tohoku Pharmaceutical University |
|---|
Principal Investigator |
NAKAZAWA Takahiro Tohoku Pharmaceutical University, 薬学部, 講師 (60296019)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ケミカルバイオロジー / 抗精神病作用メカニズム / 脳神経疾患 |
|---|
| Research Abstract |
Hirsutine, a major alkaloid in Uncaria rhynchophylla, was attenuated the apomorphine-induced climbing behavior and the MK-801-induced hyper-locomotion in mice. Hirsutine showed affinities to the σ_1, D_2 and 5-HT2Areceptors, but not to the σ_2, D_1, NMDA, GABA, and benzodiazepine receptors. The results suggest that the antipsychotic activity of hirsutine is mainly mediated through the σ_1, D_2, and 5-HT_<2A> receptors.
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