High efficient screening for bioactive compounds using C. elegans mutant strains
| Project/Area Number |
20611017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
INOUE Hideshi Tokyo University of Pharmacy and Life Science, 生命科学部, 教授 (20184765)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | C.elegans / 生物活性物質 / スクリーニング / 線虫 / プロシアニジン / Ras / 生理活性 / C. elegans / 寿命 / Rasシグナル / 生薬 / 発生 / 変異株 / 生理活性物質 / 薬剤排出トランスポーター / 感受性 |
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| Research Abstract |
Using a small invertebrate, C. elegans, and its mutant or transgenic strains, bioactivities of various compounds and the underlying mechanism were investigated. An herbal medicine Evodia rutaecarpa and its constituents, evodiamine and rutaecarpine, were found to inhibit Ras/MAP kinase pathway in C. elegans. Cacao procyanidines were found
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Report
(4 results)
Research Products
(11 results)
