Selective Removal of Cholesteryl Ester by Mid-infrared Tunable Nanosecond Pulsed Laser

• Project/Area Number: 20612006
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Quantum beam science
• Research Institution: Osaka University
• Principal Investigator: AWAZU Kunio Osaka University, 工学研究科, 教授 (30324817)
• Co-Investigator(Kenkyū-buntansha): ISHII Katsunori 大阪大学, 工学研究科, 助教 (20512073)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: レーザー治療 / 粥状動脈硬化症 / レーザー血管形成術 / 中赤外レーザー / 差周波発生 / 中赤外パルスレーザー

Research Abstract

The purpose of this study is to develop a novel less-invasive laser angioplasty. In this study, we examined the removal of atherosclerotic tissue by using the mid-infrared tunable nanosecond pulsed laser with a wavelength at 5.75μm. Selective removal of atherosclerotic tissue without a side effect to normal was observed. This technique does not perforate a vessel wall compared with a conventional excimer laser angioplasty and realize a safe treatment of atherosclerosis.

Research Products

• [Journal Article] Infrared laser therapy using IR absorption of biomolecules (2011)
  • Author(s): Kunio Awazu, et al.
  • Journal Title: Journal of physics : conference series Volume: 276巻1号 Pages: 12011-12011
  • Peer Reviewed
• [Journal Article] 血管形成術 (2011)
  • Author(s): 石井克典, 他
  • Journal Title: Medical photonics Volume: 4巻 Pages: 50-55
• [Journal Article] Less-invasive Laser Therapy and Diagnosis using a Tabletop Mid-infrared Tunable laser (2010)
  • Author(s): 間久直, 石井克典, 粟津邦男
  • Journal Title: Journal of Innovative Optical Health Sciences 3(4) Pages: 285-292
  • Peer Reviewed
• [Journal Article] Less-invasive laser therapy and diagnosis using a tabletop mid-infrared tunable laser (2010)
  • Author(s): Hisanao Hazama, et al.
  • Journal Title: Journal of innovative optical health sciences Volume: 3巻4号 Pages: 285-292
  • Peer Reviewed
• [Journal Article] Development of selective laser treatment techniques using mid-infrared tunable nanosecond pulsed laser (2010)
  • Author(s): Katsunori Ishii, et al.
  • Journal Title: Proceedings of the 32nd annual international conference of the IEEE engineering in medicine and biology society Volume: 44 Pages: 1614-1617
  • Peer Reviewed
• [Journal Article] Selective Treatment of Atherosclerotic Plaques using Nanosecond Pulsed Laser with a Wavelength of 5.75 μm for Less-invasive Laser Angioplasty (2009)
  • Author(s): 石井克典, 月元秀樹, 間久直, 粟津邦男
  • Journal Title: Proceedings of SPIE 7373
  • Peer Reviewed
• [Journal Article] 波長5.75μmのナノ秒パルスレーザーによる低侵襲なレーザー血管形成術の開発 (2009)
  • Author(s): 石井克典, 月元秀樹, 間久直, 粟津邦男
  • Journal Title: 日本レーザー医学会誌 30(2) Pages: 126-134
  • NAID: 10026088738
  • Peer Reviewed
• [Journal Article] Selective Removal of Cholesteryl Ester in Atherosclerotic Plaque by Nanosecond Pulsed Laser at 5.75 μm for Less-invasive Laser Angioplasty (2009)
  • Author(s): 石井克典, 月元秀樹, 間久直, 粟津邦男
  • Journal Title: Proceedings of SPIE 7161
  • Peer Reviewed
• [Journal Article] 波長5.75μmのナノ秒パルスレーザーによる低侵襲なレーザー血管形成術の開発 (2009)
  • Author(s): 石井克典
  • Journal Title: 日本レーザー医学会誌 30 Pages: 126-134
  • NAID: 10026088738
  • Peer Reviewed
• [Journal Article] Selective removal of cholesteryl ester in atherosclerotic plaque by nanosecond pulsed laser at 5.75 μm for less-invasive laser angioplasty (2009)
  • Author(s): Katsunori Ishii
  • Journal Title: Proceedings of SPIE (印刷中)
  • Peer Reviewed
• [Journal Article] 波長5.75μmのナノ秒パルスレーザーによる粥状動脈硬化症の低侵襲血管形成術の開発 (2009)
  • Author(s): 粟津邦男
  • Journal Title: 電気学会研究会資料 OQD-09-15-31 Pages: 35-38
  • NAID: 110007022772
• [Journal Article] 波長5.75μmのナノ秒パルスレーザーによる粥状動脈硬化症の低侵襲血管形成術の開発 (2008)
  • Author(s): 石井克典, 月元秀樹, 間久直, 粟津邦男
  • Journal Title: 生体医工学 46(5) Pages: 529-535
  • NAID: 110007022772
  • Peer Reviewed
• [Journal Article] 波長5.75μmのナノ秒パルスレーザーによる粥状動脈硬化症の低侵襲血管形成術の開発 (2008)
  • Author(s): 石井克典
  • Journal Title: 生体医工学 46 Pages: 529-535
  • NAID: 10031199805
  • Peer Reviewed
• [Presentation] 疾患選択的レーザー医療へ向けて～中赤外レーザーへの期待～ (2010)
  • Author(s): 粟津邦男
  • Organizer: 京都大学化学研究所先端ビームナノ科学センターセミナー
  • Place of Presentation: 京都大学宇治キャンパス総合研究実験棟(京都府宇治市)(招待講演)
  • Year and Date: 2010-11-17
• [Presentation] Infrared laser therapy using IR absorption of biomolecules (2010)
  • Author(s): Kunio Awazu
  • Organizer: 9th International conference on photonica and imaging in biology and medicine
  • Place of Presentation: Wuhan science and technology exhibition center (Wuhan, China)(招待講演)
  • Year and Date: 2010-11-02
• [Presentation] Novel laser treatments using mid-infrared tunable laser (2010)
  • Author(s): Kunio Awazu
  • Organizer: The 13th congress of the asian-pacific association for laser medicine & surgery
  • Place of Presentation: RAKO Hananoi hotel (Nagano, Japan)(招待講演)
  • Year and Date: 2010-10-08
• [Presentation] 赤外レーザー医療への期待 (2010)
  • Author(s): 粟津邦男
  • Organizer: BioOpto Japan 2010第2回BioOpto Japanカンファレンス
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)(招待講演)
  • Year and Date: 2010-10-01
• [Presentation] Development of selective laser treatment techniques using mid-infrared tunable nanosecond pulsed laser (2010)
  • Author(s): Katsunori Ishii, et al.
  • Organizer: 32nd annual international conference of the IEEE engineering in medicine and biology society
  • Place of Presentation: Sheraton Buenos Aires hotel & convention center (Buenos Aires, Argentina)
  • Year and Date: 2010-09-01
• [Presentation] 低侵襲レーザー血管形成術に向けたWHHLMIウサギによるin-vitro評価 (2010)
  • Author(s): 粟津邦男, 他
  • Organizer: 第4回ウサギフォーラム
  • Place of Presentation: 秋田大学工学資源学部(秋田県秋田市)
  • Year and Date: 2010-07-24
• [Presentation] Mid infrared laser therapy (2010)
  • Author(s): Kunio Awazu, et al.
  • Organizer: The 7th asia-pacific laser symposium
  • Place of Presentation: Seopwipo KAL hotel (Jeju island, Korea)(招待講演)
  • Year and Date: 2010-05-13
• [Presentation] 赤外レーザーが拓く新規バイオ・医療応用 (2010)
  • Author(s): 間久直
  • Organizer: 第7回赤外放射の応用関連学会年会
  • Place of Presentation: 株式会社島津製作所東京支社会議室 (東京都千代田区)
  • Year and Date: 2010-02-19
• [Presentation] 中赤外波長を用いた低侵襲なレーザー治療技術の開発 (2010)
  • Author(s): 石井克典
  • Organizer: レーザー学会学術講演会第30回年次大会
  • Place of Presentation: 千里ライフサイエンスセンター (大阪府豊中市)
  • Year and Date: 2010-02-02
• [Presentation] 波長5.75μmのレーザー血管形成術の開発-アブレーション飛散物及び血管内治療カテーテルの検討- (2010)
  • Author(s): 月元秀樹
  • Organizer: レーザー学会学術講演会第30回年次大会
  • Place of Presentation: 千里ライフサイエンスセンター (大阪府豊中市)
  • Year and Date: 2010-02-02
• [Presentation] Novel Endoscopic Diagnosis and Therapy Using a Mid-infrared Tunable Laser (2010)
  • Author(s): 間久直
  • Organizer: The 4^<th> Workshop on Biological Applications of Plasma/Photon Processing
  • Place of Presentation: Osaka University (Osaka, Japan)
  • Year and Date: 2010-01-26
• [Presentation] 生体組織の光学特性に基づいた低侵襲なレーザー治療技術の開発 (2010)
  • Author(s): 石井克典
  • Organizer: 日本機械学会第22回バイオエンジニアリング講演会
  • Place of Presentation: 岡山理科大学 (岡山県岡山市)
  • Year and Date: 2010-01-10
• [Presentation] Development of Selective Laser Treatment Techniques using Mid-infrared Tunable Nanosecond Pulsed Laser (2010)
  • Author(s): K.Ishii, M.Saiki, H.Hazama, K.Awazu
  • Organizer: 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC 2010)
  • Place of Presentation: Sheraton Buenos Aires Hotel & Convention Center, Buenos Aires, Argentina.
• [Presentation] 波長5.75μmのレーザー血管形成術の開発-アブレーション飛散物及び血管内治療カテーテルの検討- (2010)
  • Author(s): 月元秀樹, 石井克典, 間久直, 粟津邦男
  • Organizer: レーザー学会学術講演会第30回年次大会
  • Place of Presentation: 千里ライフサイエンスセンター,大阪府豊中市
• [Presentation] 中赤外レーザーが切り拓く低侵襲治療 (2009)
  • Author(s): 石井克典
  • Organizer: 日本分光学会先端レーザー分光部会第5回先端的レーザー分光の若手シンポジウム
  • Place of Presentation: 東京工業大学すずかけホール (神奈川県横浜市)
  • Year and Date: 2009-12-11
• [Presentation] Less-invasive Mid-infrared Laser Treatment Techniques Based on the Optical Properties of Biological Tissues (2009)
  • Author(s): 石井克典
  • Organizer: 18^<th> Congress of the International Society for Laser Surgery and Medicine
  • Place of Presentation: Hotel Grand Hill Ichigaya (Tokyo, Japan)
  • Year and Date: 2009-12-01
• [Presentation] Novel Laser Therapy and Diagnosis using Mid-infrared Laser (2009)
  • Author(s): 粟津邦男
  • Organizer: 10^<th> Chitose International Forum on Photonics Science & Technology-Optical Device and Systems, biomedical and Green Technologies-
  • Place of Presentation: Chitose Institute of Science and Technology (Hokkaido, Japan)
  • Year and Date: 2009-11-13
• [Presentation] Spectroscopic Diagnosis and Selective Treatments under Endoscope with a Mid-infrared Tunable Pulsed Laser (2009)
  • Author(s): 粟津邦男
  • Organizer: The Optical Society of Korea 20^<th> Anniversary Special Meeting
  • Place of Presentation: Gwangju Convention Center (Gwangiu, South Korea)
  • Year and Date: 2009-10-20
• [Presentation] In-vitro Study of Novel Less-invasive Laser Angioplasty using the Pulsed Laser with a Wavelength of 5.75μm (2009)
  • Author(s): 石井克典
  • Organizer: World Congress on Medical Physics and Biomedical Engineering 2009
  • Place of Presentation: ICM (Munich, Germany)
  • Year and Date: 2009-09-10
• [Presentation] Novel Laser Therapy and Diagnosis using Mid-infrared Laser (2009)
  • Author(s): 粟津邦男
  • Organizer: 31^<st> International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Hilton Minneapolis (Minnesota, USA)
  • Year and Date: 2009-09-04
• [Presentation] 波長5.75μmのコレステロールエステルに選択的な反応を利用した低侵襲なレーザー血管形成術の開発 (2009)
  • Author(s): 月元秀樹
  • Organizer: 第22回日本レーザー医学会関西地方会
  • Place of Presentation: ザ・グランリゾート・エレガンテ白浜 (和歌山県西牟婁郡)
  • Year and Date: 2009-08-08
• [Presentation] レーザー医療のフロンティア (2009)
  • Author(s): 粟津邦男
  • Organizer: 文部科学省学術フロンティア推進事業 (同志社大学) 医工学研究の新展開-生体適合材料と福祉・介護システムの開発-第9回医工学研究センターシンポジウム
  • Place of Presentation: 同志社大学医工学研究センター (京都府京田辺市)
  • Year and Date: 2009-08-01
• [Presentation] Selective Treatment of Atherosclerotic Plaques Using Nanosecond Pulsed Laser with a Wavelength of 5.75μm for Less-invasive Laser Angioplasty (2009)
  • Author(s): 石井克典
  • Organizer: European Conference on Biomedical Optics 2009
  • Place of Presentation: ICM (Munich, Germany)
  • Year and Date: 2009-06-18
• [Presentation] Endoscopic Diagnosis and Selective Treatments using a Mid-infrared Tunable Pulsed Laser (2009)
  • Author(s): 粟津邦男
  • Organizer: The 4^<th> Asian and Pacific Rim Symposium on Biophotonics
  • Place of Presentation: Shilla Hotel (Jeju island, South Korea)
  • Year and Date: 2009-05-29
• [Presentation] Development of Less-invasive Laser Angioplasty for Atherosclerosis using Nanosecond Pulsed Laser at 5.75μm (2009)
  • Author(s): 石井克典
  • Organizer: The 4^<th> Asian and Pacific Rim Symposium on Biophotonics
  • Place of Presentation: Shilla Hotel, (Jeju island, South Korea)
  • Year and Date: 2009-05-29
• [Presentation] 波長5.75μmのナノ秒パルスレーザーによる粥状動脈硬化部位の低侵襲切除 (2009)
  • Author(s): 月元秀樹
  • Organizer: 第48回日本生体医工学会大会
  • Place of Presentation: タワーホール船堀 (東京都江戸川区)
  • Year and Date: 2009-04-25
• [Presentation] 波長5.75μmのナノ秒パルスレーザーを用いた低侵襲なレーザー血管形成術の開発 (2009)
  • Author(s): 石井克典
  • Organizer: 日本医工学治療学会第25回学術大会
  • Place of Presentation: 大阪国際会議場 (大阪府大阪市)
  • Year and Date: 2009-04-11
• [Presentation] DFGレーザーによる高脂血症ウサギの血管形成 (2009)
  • Author(s): 粟津邦男
  • Organizer: 電気学会光・量子デバイス研究会
  • Place of Presentation: 埼玉県和光市理化学研究所和光研究所
  • Year and Date: 2009-02-14
• [Presentation] Selective removal of cholesterol ester in atherosclerotic plaque by nanosecond pulsed laser at 5. 75 μm for less-invasive laser angioplasty (2009)
  • Author(s): Katsunori Ishi i
  • Organizer: Photonics West BiOS 2009
  • Place of Presentation: San Jose, USASan Jose Convention Ctr
  • Year and Date: 2009-01-24
• [Presentation] 膨潤状態の動脈硬化部位に対する波長5. 75μmナノ秒パルスレーザーの切除効果の検討 (2009)
  • Author(s): 月元秀樹
  • Organizer: レーザー学会学術講演会第2 9回年次大会
  • Place of Presentation: 徳島県徳島市徳島大学
  • Year and Date: 2009-01-12
• [Presentation] In-vitro Study of Novel Less-invasive Laser Angioplasty using the Pulsed Laser with a Wavelength of 5.75 μm (2009)
  • Author(s): 石井克典, 月元秀樹, 間久直, 粟津邦男
  • Organizer: World Congress on Medical Physics and Biomedical Engineering 2009 (WC 2009)
  • Place of Presentation: Munich ICM, Munich, Germany.
• [Presentation] Selective Treatment of Atherosclerotic Plaques Using Nanosecond Pulsed Laser with a Wavelength of 5.75μm for Less-invasive Laser Angioplasty (2009)
  • Author(s): 石井克典, 月元秀樹, 間久直, 粟津邦男
  • Organizer: European Conference on Biomedical Optics (ECBO) 2009
  • Place of Presentation: ICM, Munich, Germany.
• [Presentation] 波長5. 75μmのナノ秒パルスレーザーによる低侵襲な血管形成術の開発 (2008)
  • Author(s): 石井克典
  • Organizer: 第2 9回日本レーザー医学会総会
  • Place of Presentation: 東京都八王子市東京工科大学片柳研究所
  • Year and Date: 2008-11-16
• [Presentation] 波長5. 75μmのナノ秒パルスレーザーによる粥状動脈硬化症の低侵襲血管形成術の開発 (2008)
  • Author(s): 石井克典
  • Organizer: 生体医工学シンポジウム2008
  • Place of Presentation: 大阪府豊中市大阪大学基礎工学部
  • Year and Date: 2008-09-19
• [Presentation] 中赤外レーザーを用いた低侵襲なレーザー治療技術の検討〜動脈硬化治療と胆石破砕治療を中心に〜 (2008)
  • Author(s): 石井克典
  • Organizer: レーザー学会第377回研究会レーザー医学・生物学応用
  • Place of Presentation: 宮城県仙台市東北大学電気通信研究所
  • Year and Date: 2008-09-12
• [Presentation] 波長5.75μmの中赤外レーザーによる血管形成術のWHHLMIウサギを用いた検討 (2008)
  • Author(s): 粟津邦男
  • Organizer: 第3回ウサギフォーラム
  • Place of Presentation: 兵庫県神戸市神戸大学神緑会館
  • Year and Date: 2008-07-26
• [Presentation] 波長5.75 μmのナノ秒パルスレーザーによる粥状動脈硬化内膜の低侵襲切除 (2008)
  • Author(s): 月元秀樹
  • Organizer: 第21回日本レーザー医学会関西地方会
  • Place of Presentation: 大阪府大阪市大阪市立大学医学部
  • Year and Date: 2008-07-19
• [Presentation] 中赤外波長可変パルスレーザーによる粥状動脈硬化内膜のin-vitro選択的分解除去 (2008)
  • Author(s): 石井克典
  • Organizer: 第47回日本生体医工学会
  • Place of Presentation: 兵庫県神戸市神戸国際会議場
  • Year and Date: 2008-05-10
• [Presentation] 中赤外レーザー治療用ダイヤモンドマイクロレンズ付中空光ファイバーカテーテルの開発 (2008)
  • Author(s): 石井克典
  • Organizer: 第47回日本生体医工学会
  • Place of Presentation: 兵庫県神戸市神戸国際会議場
  • Year and Date: 2008-05-09
• [Presentation] 波長5.75μmのナノ秒パルスレーザーによる低侵襲な血管形成術の開発 (2008)
  • Author(s): 石井克典, 月元秀樹, 間久直, 粟津邦男
  • Organizer: 第29回日本レーザー医学会総会
  • Place of Presentation: 東京工科大学八王子キャンパス,東京都八王子市
• [Book] 第16章生体分子振動領域での新しいレーザー診断・治療,次世代光医療-レーザー技術の臨床への橋渡し-(粟津邦男監修) (2010)
  • Author(s): 石井克典, 粟津邦男
  • Publisher: シーエムシー出版
• [Book] 次世代光医療-レーザー技術の臨床への橋渡し-,第16章生体分子振動領域での新しいレーザー診断・治療 (2010)
  • Author(s): 石井克典, 粟津邦男
  • Total Pages: 13
  • Publisher: シーエムシー出版