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Selective Removal of Cholesteryl Ester by Mid-infrared Tunable Nanosecond Pulsed Laser

Research Project

Project/Area Number 20612006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Quantum beam science
Research InstitutionOsaka University

Principal Investigator

AWAZU Kunio  Osaka University, 工学研究科, 教授 (30324817)

Co-Investigator(Kenkyū-buntansha) ISHII Katsunori  大阪大学, 工学研究科, 助教 (20512073)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywordsレーザー治療 / 粥状動脈硬化症 / レーザー血管形成術 / 中赤外レーザー / 差周波発生 / 中赤外パルスレーザー
Research Abstract

The purpose of this study is to develop a novel less-invasive laser angioplasty. In this study, we examined the removal of atherosclerotic tissue by using the mid-infrared tunable nanosecond pulsed laser with a wavelength at 5.75μm. Selective removal of atherosclerotic tissue without a side effect to normal was observed. This technique does not perforate a vessel wall compared with a conventional excimer laser angioplasty and realize a safe treatment of atherosclerosis.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (55 results)

All 2011 2010 2009 2008

All Journal Article (13 results) (of which Peer Reviewed: 11 results) Presentation (40 results) Book (2 results)

  • [Journal Article] Infrared laser therapy using IR absorption of biomolecules2011

    • Author(s)
      Kunio Awazu, et al.
    • Journal Title

      Journal of physics : conference series

      Volume: 276巻1号 Pages: 12011-12011

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血管形成術2011

    • Author(s)
      石井克典, 他
    • Journal Title

      Medical photonics

      Volume: 4巻 Pages: 50-55

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Less-invasive Laser Therapy and Diagnosis using a Tabletop Mid-infrared Tunable laser2010

    • Author(s)
      間久直, 石井克典, 粟津邦男
    • Journal Title

      Journal of Innovative Optical Health Sciences 3(4)

      Pages: 285-292

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Less-invasive laser therapy and diagnosis using a tabletop mid-infrared tunable laser2010

    • Author(s)
      Hisanao Hazama, et al.
    • Journal Title

      Journal of innovative optical health sciences

      Volume: 3巻4号 Pages: 285-292

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of selective laser treatment techniques using mid-infrared tunable nanosecond pulsed laser2010

    • Author(s)
      Katsunori Ishii, et al.
    • Journal Title

      Proceedings of the 32nd annual international conference of the IEEE engineering in medicine and biology society

      Volume: 44 Pages: 1614-1617

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective Treatment of Atherosclerotic Plaques using Nanosecond Pulsed Laser with a Wavelength of 5.75 μm for Less-invasive Laser Angioplasty2009

    • Author(s)
      石井克典, 月元秀樹, 間久直, 粟津邦男
    • Journal Title

      Proceedings of SPIE 7373

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 波長5.75μmのナノ秒パルスレーザーによる低侵襲なレーザー血管形成術の開発2009

    • Author(s)
      石井克典, 月元秀樹, 間久直, 粟津邦男
    • Journal Title

      日本レーザー医学会誌 30(2)

      Pages: 126-134

    • NAID

      10026088738

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective Removal of Cholesteryl Ester in Atherosclerotic Plaque by Nanosecond Pulsed Laser at 5.75 μm for Less-invasive Laser Angioplasty2009

    • Author(s)
      石井克典, 月元秀樹, 間久直, 粟津邦男
    • Journal Title

      Proceedings of SPIE 7161

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 波長5.75μmのナノ秒パルスレーザーによる低侵襲なレーザー血管形成術の開発2009

    • Author(s)
      石井克典
    • Journal Title

      日本レーザー医学会誌 30

      Pages: 126-134

    • NAID

      10026088738

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective removal of cholesteryl ester in atherosclerotic plaque by nanosecond pulsed laser at 5.75 μm for less-invasive laser angioplasty2009

    • Author(s)
      Katsunori Ishii
    • Journal Title

      Proceedings of SPIE (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 波長5.75μmのナノ秒パルスレーザーによる粥状動脈硬化症の低侵襲血管形成術の開発2009

    • Author(s)
      粟津邦男
    • Journal Title

      電気学会研究会資料 OQD-09-15-31

      Pages: 35-38

    • NAID

      110007022772

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 波長5.75μmのナノ秒パルスレーザーによる粥状動脈硬化症の低侵襲血管形成術の開発2008

    • Author(s)
      石井克典, 月元秀樹, 間久直, 粟津邦男
    • Journal Title

      生体医工学 46(5)

      Pages: 529-535

    • NAID

      110007022772

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 波長5.75μmのナノ秒パルスレーザーによる粥状動脈硬化症の低侵襲血管形成術の開発2008

    • Author(s)
      石井克典
    • Journal Title

      生体医工学 46

      Pages: 529-535

    • NAID

      10031199805

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 疾患選択的レーザー医療へ向けて~中赤外レーザーへの期待~2010

    • Author(s)
      粟津邦男
    • Organizer
      京都大学化学研究所先端ビームナノ科学センターセミナー
    • Place of Presentation
      京都大学宇治キャンパス総合研究実験棟(京都府宇治市)(招待講演)
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Infrared laser therapy using IR absorption of biomolecules2010

    • Author(s)
      Kunio Awazu
    • Organizer
      9th International conference on photonica and imaging in biology and medicine
    • Place of Presentation
      Wuhan science and technology exhibition center (Wuhan, China)(招待講演)
    • Year and Date
      2010-11-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Novel laser treatments using mid-infrared tunable laser2010

    • Author(s)
      Kunio Awazu
    • Organizer
      The 13th congress of the asian-pacific association for laser medicine & surgery
    • Place of Presentation
      RAKO Hananoi hotel (Nagano, Japan)(招待講演)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 赤外レーザー医療への期待2010

    • Author(s)
      粟津邦男
    • Organizer
      BioOpto Japan 2010第2回BioOpto Japanカンファレンス
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)(招待講演)
    • Year and Date
      2010-10-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of selective laser treatment techniques using mid-infrared tunable nanosecond pulsed laser2010

    • Author(s)
      Katsunori Ishii, et al.
    • Organizer
      32nd annual international conference of the IEEE engineering in medicine and biology society
    • Place of Presentation
      Sheraton Buenos Aires hotel & convention center (Buenos Aires, Argentina)
    • Year and Date
      2010-09-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低侵襲レーザー血管形成術に向けたWHHLMIウサギによるin-vitro評価2010

    • Author(s)
      粟津邦男, 他
    • Organizer
      第4回ウサギフォーラム
    • Place of Presentation
      秋田大学工学資源学部(秋田県秋田市)
    • Year and Date
      2010-07-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mid infrared laser therapy2010

    • Author(s)
      Kunio Awazu, et al.
    • Organizer
      The 7th asia-pacific laser symposium
    • Place of Presentation
      Seopwipo KAL hotel (Jeju island, Korea)(招待講演)
    • Year and Date
      2010-05-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 赤外レーザーが拓く新規バイオ・医療応用2010

    • Author(s)
      間久直
    • Organizer
      第7回赤外放射の応用関連学会年会
    • Place of Presentation
      株式会社島津製作所東京支社会議室 (東京都千代田区)
    • Year and Date
      2010-02-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 中赤外波長を用いた低侵襲なレーザー治療技術の開発2010

    • Author(s)
      石井克典
    • Organizer
      レーザー学会学術講演会第30回年次大会
    • Place of Presentation
      千里ライフサイエンスセンター (大阪府豊中市)
    • Year and Date
      2010-02-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 波長5.75μmのレーザー血管形成術の開発-アブレーション飛散物及び血管内治療カテーテルの検討-2010

    • Author(s)
      月元秀樹
    • Organizer
      レーザー学会学術講演会第30回年次大会
    • Place of Presentation
      千里ライフサイエンスセンター (大阪府豊中市)
    • Year and Date
      2010-02-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Novel Endoscopic Diagnosis and Therapy Using a Mid-infrared Tunable Laser2010

    • Author(s)
      間久直
    • Organizer
      The 4^<th> Workshop on Biological Applications of Plasma/Photon Processing
    • Place of Presentation
      Osaka University (Osaka, Japan)
    • Year and Date
      2010-01-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体組織の光学特性に基づいた低侵襲なレーザー治療技術の開発2010

    • Author(s)
      石井克典
    • Organizer
      日本機械学会第22回バイオエンジニアリング講演会
    • Place of Presentation
      岡山理科大学 (岡山県岡山市)
    • Year and Date
      2010-01-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Selective Laser Treatment Techniques using Mid-infrared Tunable Nanosecond Pulsed Laser2010

    • Author(s)
      K.Ishii, M.Saiki, H.Hazama, K.Awazu
    • Organizer
      32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC 2010)
    • Place of Presentation
      Sheraton Buenos Aires Hotel & Convention Center, Buenos Aires, Argentina.
    • Related Report
      2010 Final Research Report
  • [Presentation] 波長5.75μmのレーザー血管形成術の開発-アブレーション飛散物及び血管内治療カテーテルの検討-2010

    • Author(s)
      月元秀樹, 石井克典, 間久直, 粟津邦男
    • Organizer
      レーザー学会学術講演会第30回年次大会
    • Place of Presentation
      千里ライフサイエンスセンター,大阪府豊中市
    • Related Report
      2010 Final Research Report
  • [Presentation] 中赤外レーザーが切り拓く低侵襲治療2009

    • Author(s)
      石井克典
    • Organizer
      日本分光学会先端レーザー分光部会第5回先端的レーザー分光の若手シンポジウム
    • Place of Presentation
      東京工業大学すずかけホール (神奈川県横浜市)
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Less-invasive Mid-infrared Laser Treatment Techniques Based on the Optical Properties of Biological Tissues2009

    • Author(s)
      石井克典
    • Organizer
      18^<th> Congress of the International Society for Laser Surgery and Medicine
    • Place of Presentation
      Hotel Grand Hill Ichigaya (Tokyo, Japan)
    • Year and Date
      2009-12-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Novel Laser Therapy and Diagnosis using Mid-infrared Laser2009

    • Author(s)
      粟津邦男
    • Organizer
      10^<th> Chitose International Forum on Photonics Science & Technology-Optical Device and Systems, biomedical and Green Technologies-
    • Place of Presentation
      Chitose Institute of Science and Technology (Hokkaido, Japan)
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spectroscopic Diagnosis and Selective Treatments under Endoscope with a Mid-infrared Tunable Pulsed Laser2009

    • Author(s)
      粟津邦男
    • Organizer
      The Optical Society of Korea 20^<th> Anniversary Special Meeting
    • Place of Presentation
      Gwangju Convention Center (Gwangiu, South Korea)
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] In-vitro Study of Novel Less-invasive Laser Angioplasty using the Pulsed Laser with a Wavelength of 5.75μm2009

    • Author(s)
      石井克典
    • Organizer
      World Congress on Medical Physics and Biomedical Engineering 2009
    • Place of Presentation
      ICM (Munich, Germany)
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Novel Laser Therapy and Diagnosis using Mid-infrared Laser2009

    • Author(s)
      粟津邦男
    • Organizer
      31^<st> International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Hilton Minneapolis (Minnesota, USA)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 波長5.75μmのコレステロールエステルに選択的な反応を利用した低侵襲なレーザー血管形成術の開発2009

    • Author(s)
      月元秀樹
    • Organizer
      第22回日本レーザー医学会関西地方会
    • Place of Presentation
      ザ・グランリゾート・エレガンテ白浜 (和歌山県西牟婁郡)
    • Year and Date
      2009-08-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] レーザー医療のフロンティア2009

    • Author(s)
      粟津邦男
    • Organizer
      文部科学省学術フロンティア推進事業 (同志社大学) 医工学研究の新展開-生体適合材料と福祉・介護システムの開発-第9回医工学研究センターシンポジウム
    • Place of Presentation
      同志社大学医工学研究センター (京都府京田辺市)
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Selective Treatment of Atherosclerotic Plaques Using Nanosecond Pulsed Laser with a Wavelength of 5.75μm for Less-invasive Laser Angioplasty2009

    • Author(s)
      石井克典
    • Organizer
      European Conference on Biomedical Optics 2009
    • Place of Presentation
      ICM (Munich, Germany)
    • Year and Date
      2009-06-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Endoscopic Diagnosis and Selective Treatments using a Mid-infrared Tunable Pulsed Laser2009

    • Author(s)
      粟津邦男
    • Organizer
      The 4^<th> Asian and Pacific Rim Symposium on Biophotonics
    • Place of Presentation
      Shilla Hotel (Jeju island, South Korea)
    • Year and Date
      2009-05-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Less-invasive Laser Angioplasty for Atherosclerosis using Nanosecond Pulsed Laser at 5.75μm2009

    • Author(s)
      石井克典
    • Organizer
      The 4^<th> Asian and Pacific Rim Symposium on Biophotonics
    • Place of Presentation
      Shilla Hotel, (Jeju island, South Korea)
    • Year and Date
      2009-05-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 波長5.75μmのナノ秒パルスレーザーによる粥状動脈硬化部位の低侵襲切除2009

    • Author(s)
      月元秀樹
    • Organizer
      第48回日本生体医工学会大会
    • Place of Presentation
      タワーホール船堀 (東京都江戸川区)
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 波長5.75μmのナノ秒パルスレーザーを用いた低侵襲なレーザー血管形成術の開発2009

    • Author(s)
      石井克典
    • Organizer
      日本医工学治療学会第25回学術大会
    • Place of Presentation
      大阪国際会議場 (大阪府大阪市)
    • Year and Date
      2009-04-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] DFGレーザーによる高脂血症ウサギの血管形成2009

    • Author(s)
      粟津邦男
    • Organizer
      電気学会光・量子デバイス研究会
    • Place of Presentation
      埼玉県和光市理化学研究所和光研究所
    • Year and Date
      2009-02-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Selective removal of cholesterol ester in atherosclerotic plaque by nanosecond pulsed laser at 5. 75 μm for less-invasive laser angioplasty2009

    • Author(s)
      Katsunori Ishi i
    • Organizer
      Photonics West BiOS 2009
    • Place of Presentation
      San Jose, USASan Jose Convention Ctr
    • Year and Date
      2009-01-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 膨潤状態の動脈硬化部位に対する波長5. 75μmナノ秒パルスレーザーの切除効果の検討2009

    • Author(s)
      月元秀樹
    • Organizer
      レーザー学会学術講演会第2 9回年次大会
    • Place of Presentation
      徳島県徳島市徳島大学
    • Year and Date
      2009-01-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] In-vitro Study of Novel Less-invasive Laser Angioplasty using the Pulsed Laser with a Wavelength of 5.75 μm2009

    • Author(s)
      石井克典, 月元秀樹, 間久直, 粟津邦男
    • Organizer
      World Congress on Medical Physics and Biomedical Engineering 2009 (WC 2009)
    • Place of Presentation
      Munich ICM, Munich, Germany.
    • Related Report
      2010 Final Research Report
  • [Presentation] Selective Treatment of Atherosclerotic Plaques Using Nanosecond Pulsed Laser with a Wavelength of 5.75μm for Less-invasive Laser Angioplasty2009

    • Author(s)
      石井克典, 月元秀樹, 間久直, 粟津邦男
    • Organizer
      European Conference on Biomedical Optics (ECBO) 2009
    • Place of Presentation
      ICM, Munich, Germany.
    • Related Report
      2010 Final Research Report
  • [Presentation] 波長5. 75μmのナノ秒パルスレーザーによる低侵襲な血管形成術の開発2008

    • Author(s)
      石井克典
    • Organizer
      第2 9回日本レーザー医学会総会
    • Place of Presentation
      東京都八王子市東京工科大学片柳研究所
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 波長5. 75μmのナノ秒パルスレーザーによる粥状動脈硬化症の低侵襲血管形成術の開発2008

    • Author(s)
      石井克典
    • Organizer
      生体医工学シンポジウム2008
    • Place of Presentation
      大阪府豊中市大阪大学基礎工学部
    • Year and Date
      2008-09-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 中赤外レーザーを用いた低侵襲なレーザー治療技術の検討〜動脈硬化治療と胆石破砕治療を中心に〜2008

    • Author(s)
      石井克典
    • Organizer
      レーザー学会第377回研究会レーザー医学・生物学応用
    • Place of Presentation
      宮城県仙台市東北大学電気通信研究所
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 波長5.75μmの中赤外レーザーによる血管形成術のWHHLMIウサギを用いた検討2008

    • Author(s)
      粟津邦男
    • Organizer
      第3回ウサギフォーラム
    • Place of Presentation
      兵庫県神戸市神戸大学神緑会館
    • Year and Date
      2008-07-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 波長5.75 μmのナノ秒パルスレーザーによる粥状動脈硬化内膜の低侵襲切除2008

    • Author(s)
      月元秀樹
    • Organizer
      第21回日本レーザー医学会関西地方会
    • Place of Presentation
      大阪府大阪市大阪市立大学医学部
    • Year and Date
      2008-07-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 中赤外波長可変パルスレーザーによる粥状動脈硬化内膜のin-vitro選択的分解除去2008

    • Author(s)
      石井克典
    • Organizer
      第47回日本生体医工学会
    • Place of Presentation
      兵庫県神戸市神戸国際会議場
    • Year and Date
      2008-05-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 中赤外レーザー治療用ダイヤモンドマイクロレンズ付中空光ファイバーカテーテルの開発2008

    • Author(s)
      石井克典
    • Organizer
      第47回日本生体医工学会
    • Place of Presentation
      兵庫県神戸市神戸国際会議場
    • Year and Date
      2008-05-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 波長5.75μmのナノ秒パルスレーザーによる低侵襲な血管形成術の開発2008

    • Author(s)
      石井克典, 月元秀樹, 間久直, 粟津邦男
    • Organizer
      第29回日本レーザー医学会総会
    • Place of Presentation
      東京工科大学八王子キャンパス,東京都八王子市
    • Related Report
      2010 Final Research Report
  • [Book] 第16章生体分子振動領域での新しいレーザー診断・治療,次世代光医療-レーザー技術の臨床への橋渡し-(粟津邦男監修)2010

    • Author(s)
      石井克典, 粟津邦男
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Final Research Report
  • [Book] 次世代光医療-レーザー技術の臨床への橋渡し-,第16章生体分子振動領域での新しいレーザー診断・治療2010

    • Author(s)
      石井克典, 粟津邦男
    • Total Pages
      13
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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