New synthetic methodology of heterocycles based on ubiquitous metal catalysts
| Project/Area Number |
20613010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Element strategy
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| Research Institution | Hiroshima University |
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Principal Investigator |
TAKAKI Ken Hiroshima University, 大学院・工学研究科, 教授 (80116615)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ユビキタス金属 / 触媒 / 複素環 / ボーダーライン触媒 / 鉄触媒 / ビスマス触媒 / 環化反応 / ピロール / N,O-アセタール / ヒドロアリール化反応 / ボーダーライン金属触媒 / ビスマス / 鉄 |
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| Research Abstract |
Ubiquitous metals like iron and bismuth have been found to act as very reactive borderline catalysts due to their π- and σ-acidities. Based on these characteristics, intramolecular carbo-oxycarbonylation of 3-alkynyl esters, pyrrole synthesis from 2-propynylamines and 1,3-diketones, cyclization of alkenyl N,O-acetals, alkynylcyclopropanation of 1,6-enynes, and intramolecular hydroarylation of alkynes have been succeeded very effectively under mild conditions, which provide new synthetic methods for many useful heterocycles.
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Report
(3 results)
Research Products
(21 results)
