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位相制御された音響放射圧による生体内部の歪み加振の効率化に関する研究

Research Project

Project/Area Number 20650076
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Medical systems
Research InstitutionTohoku University

Principal Investigator

金井 浩  Tohoku University, 大学院・工学研究科, 教授 (10185895)

Co-Investigator(Kenkyū-buntansha) 長谷川 英之  東北大学, 大学院・医工学研究科, 准教授 (00344698)
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2009: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2008: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords超音波加振 / 医用超音波工学 / 組織弾性特性 / 位相差トラッキング法 / 音響放射圧 / 線状集束トランスジューサ / 周波数特性 / 鍼灸治療
Research Abstract

生体内部の硬さ計測の一般的な方法では,力を加えて内部に生じた歪み量を計測している.本研究では,対象物の両側から2つの音響放射圧を同期させて照射し,対象物内部に歪みを発生させ,その歪みの空間分布を別の超音波によって可視化するための手法を基礎的に検討し,生体の機械的特性評価へ応用した.1つの音響放射圧によって生体内部に生じる変位は数ミクロンと小さいため,効率的な加振方法を検討する必要がある.そこで本年度は次の研究課題を行ない解決した.
(1)加振の効率化の検討:線状集束トランスジューサによる実験:対象物を点で加振するのではなく,奥行き方向に線状の領域にわたり対象物を加振できるような広い開口のトランスジューサを設計・試作し,加振の効率が1.5倍に向上し,歪みを精度良く計測することが可能となった.(2)歪みの空間分布の超音波計測:超音波加振によって生じる歪みの分布を別の超音波で計測する場合の両方の超音波干渉を防ぐため,超音波周波数の大きく異なる組み合わせを採用し,加振を連続的に行った(計測用20MHz,加振用500kHz).加振用超音波の連続的照射が,超音波計測に影響がないことを実験的に確認した.(3)異方性の計測:弾性率に異方性がある筋肉(トリ肉)に関して,線維の方向によって加振され易さに差異があることを実験的に確認した.(4)総括:音響放射圧を複数同期させた新しい超音波加振による生体組織内での局所的歪みの発生法と,その内部歪みや変位の空間分布の超音波による計測システムに関する研究を実験的に行った.加振効率の向上のために線状集束超音波トランスジューサを試作し,計測用超音波と加振超音波が干渉しない工夫などを導入し実験的に確認した.さらに生体組織への応用を行った結果,生体組織の硬さを内部にわたって評価できる可能性を示すことができた.今後,弾性率分布の算出などへの発展が期待できる.

Report

(2 results)
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (41 results)

All 2010 2009 2008 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (18 results) Book (3 results) Remarks (2 results)

  • [Journal Article] Propagation of Vibration Caused by Electrical Excitation in the Normal Human Heart2009

    • Author(s)
      Hiroshi Kanai
    • Journal Title

      Ultrasound in Medicine & Biology 35

      Pages: 382-394

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase-Sensitive Lateral Motion Estimator for Measurement of Aftery-Wall Displacement-Phantom Study2009

    • Author(s)
      Hideyuki Hasegawa
    • Journal Title

      IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 56

      Pages: 2450-2462

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of Scatterer Diameter Using Ultrasonic Backscattering Property for Assessment of Red flood Cell Aggregation2009

    • Author(s)
      Nobutaka Saitoh
    • Journal Title

      Japanese Journal of Applied Physics 48

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flow-Mediated Change in Viscoelastic Property of Radial Arterial Wall Measured by 22MHz Ultrasound2009

    • Author(s)
      Kazuki Ikeshita
    • Journal Title

      Japanese Journal of Applied Physics 48

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between upper limb peripheral artery stiffness using the radial artery and atherosclerotic parameters2009

    • Author(s)
      Shuumarjav Uurtuya
    • Journal Title

      Journal of Medical Ultrasonics 36

      Pages: 129-135

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Plaque Stabilization by Fluvastatin with Carotid Intima-Medial Elasticity Measured by a Transcutaneous Ultrasonic-Based Tissue Characterization System2009

    • Author(s)
      Toshio Yamagishi
    • Journal Title

      Journal of Atherosclerosis and Thrombosis 16

      Pages: 662-673

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carotid Arterial Elasticity is a Sensitive Atherosclerosis Value Reflecting Visceral Fat Accumulation in Obese subjects2009

    • Author(s)
      Ai Tokita
    • Journal Title

      Atherosclerosis 206

      Pages: 168-172

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 超音波RF信号のコヒーレンスに基づく心臓壁領域同定2009

    • Author(s)
      高橋広樹
    • Journal Title

      超音波医学 36

      Pages: 679-681

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Lifestyle-Related Diseases on Carotid Arterial Wall Elasticity as Evaluated by an Ultrasonic Phased-Tracking Method in Japanese Subjects2009

    • Author(s)
      Toshio Yamagishi
    • Journal Title

      Journal of Atherosclerosis and Thrombosis 16

      Pages: 782-791

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of Gaps in Digital Joints by Measurement of Ultrasound Transmission Using a Linear Array2009

    • Author(s)
      Hideyuki Hasegawa
    • Journal Title

      Ultrasound in Medicine and Biology 35

      Pages: 382-394

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal Region-of-Interest Settings for Tissue Characterization Based on Ultrasonic Elasticity Imaging2008

    • Author(s)
      Kentaro Tsuzuki
    • Journal Title

      Ultrasound in Medicine and Biology 34

      Pages: 573-585

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Automated Segmentation of Heart Wall Using Coherence Among Ultrasonic RF Echoes2008

    • Author(s)
      Takaomi Kinugawa
    • Journal Title

      Japanese Journal of Applied Physics 47

      Pages: 4155-4164

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrasonic Measurement of Transient Change in the Stress-Strain Property of Radial Arterial Wall Caused by Endothelial-Dependent Vasodilation2008

    • Author(s)
      Kazuki Ikeshita
    • Journal Title

      Japanese Journal of Applied Physics 47

      Pages: 4165-4169

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Threshold Setting for Likelihood Function for Elasticity-Based Tissue Classification of Arterial Wall by Evaluating Variance in Measurement of Radial Strain2008

    • Author(s)
      Kentaro Tsuzuki
    • Journal Title

      Japanese Journal of Applied Physics 47

      Pages: 4180-4187

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrasonic Measurement of Strain Distribution Inside Object Cyclically Compressed by Dual Acoustic Radiation Force2008

    • Author(s)
      Yoshitaka Odagiri
    • Journal Title

      Japanese Journal of Applied Physics 47

      Pages: 4193-4199

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of Influence of Variation in Center Frequencies of RF Echoes on Estimation of Artery-Wall Strain2008

    • Author(s)
      Hideyuki Hasegawa
    • Journal Title

      IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 55

      Pages: 1921-1934

    • NAID

      120002338359

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood flow structure and dynamics, and ejection mechanism in the left ventricle : Analysis using echo-dynamography2008

    • Author(s)
      Motonao Tanaka
    • Journal Title

      Journal of Cardiology 52

      Pages: 86-101

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous Imaging of Artery-Wall Strain and Blood Flow by High Frame Rate Acquisition of RF Signals2008

    • Author(s)
      Hideyuki Hasegawa
    • Journal Title

      IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 55

      Pages: 2626-2639

    • NAID

      120002338360

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Evaluation of Transient Change in Viscoelasticity of Arterial Wall during Flow-Mediated Dilation2010

    • Author(s)
      Hiroshi Kanai
    • Organizer
      12th International Symposium of 2007 Tohoku University Global COE Program Global Nano-Biomedical Engineering Education and Research Network Centre
    • Place of Presentation
      Sendai
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Artery-Wall Elasticity Imaging with Ultrasound2010

    • Author(s)
      Hideyuki Hasegawa
    • Organizer
      5rd International Symposium on Medical, Bio- and Nano-Electronics in Sendai
    • Place of Presentation
      Sendai
    • Year and Date
      2010-02-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Vascular Elasticity Imaging with Transcutaneous Ultrasound2010

    • Author(s)
      Hideyuki Hasegawa
    • Organizer
      12th International Symposium on Advanced Biomedical Ultrasound
    • Place of Presentation
      Sendai
    • Year and Date
      2010-02-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Imaging of Vibration Propagating on Heart Wall2010

    • Author(s)
      Hiroshi Kanai
    • Organizer
      12th International Symposium on Advanced Biomedical Ultrasound
    • Place of Presentation
      Sendai
    • Year and Date
      2010-02-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Carotid Artery Elasticity Using the Phased-Tracking Method Is Useful as a Risk Factor for Coronary Artery Disease2009

    • Author(s)
      Yukiyo Ogata
    • Organizer
      EUROSON 2009
    • Place of Presentation
      Edinburgh, United Kingdom
    • Year and Date
      2009-12-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] In Vivo Measurements of Change in Viscoelasticity of Arterial Wall during The Flow-Mediated Dilation2009

    • Author(s)
      Hiroshi Kanai
    • Organizer
      ASME 2009 International Mechanical Engineering Congress & Exposition IMECE2009
    • Place of Presentation
      Lake Buena Vista, USA
    • Year and Date
      2009-11-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Lateral Motion Estimator for Measurement of Artery-Wall Displacement2009

    • Author(s)
      Hideyuki Hasegawa
    • Organizer
      IEEE 2009 International Ultrasonics Symposium
    • Place of Presentation
      Roma, Italy
    • Year and Date
      2009-09-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Anisotropy in Three-Dimensional Propagation of Electric Excitation in Human Heart2009

    • Author(s)
      Hiroshi Kanai
    • Organizer
      IEEE 2009 International Ultrasonics Symposium
    • Place of Presentation
      Roma, Italy
    • Year and Date
      2009-09-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Propagation of Electric Excitation and Vibrations in the Human Heart2009

    • Author(s)
      Hiroshi Kanai
    • Organizer
      10th International Symposium of 2007 Tohoku University Global COE Program Global Nano-Biomedical Engineering Education and Research Network Centre
    • Place of Presentation
      Christchurch, New Zealand
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] High Frame Rate Ultrasonic Imaging of Artery-Wall Strain and Blood Flow2009

    • Author(s)
      Hideyuki Hasegawa
    • Organizer
      10th International Symposium of 2007 Tohoku University Global COE Program Global Nano-Biomedical Engineering Education and Research Network Centre
    • Place of Presentation
      Christchurch, New Zealand
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Flow-Mediated Change in Viscoelasticity of Radial Artery Noninvasively Measured by 22-MHz Ultrasound2008

    • Author(s)
      Kazuki Ikeshita
    • Organizer
      IEEE 2008 International Ultrasonics Symposium
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-11-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Accurate Ultrasonic Measurement of Myocardial Regional Strain Rate at High Temporal and Spatial Resolutions2008

    • Author(s)
      Yasunori Honjo
    • Organizer
      IEEE 2008 International Ultrasonics Symposium
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-11-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Assessment of Red Blood Cell Aggregation Using Normalized Power Spectrum of High Frequency Ultrasound2008

    • Author(s)
      Nobutaka Saitoh
    • Organizer
      IEEE 2008 International Ultrasonics Symposium
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-11-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ultrasonic Imaging of 3-Dimensional Propagation of Electric Excitation and Vibrations in Human Heart2008

    • Author(s)
      Hiroshi Kanai
    • Organizer
      IEEE 2008 International Ultrasonics Symposium
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-11-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Simultaneous imaging of artery-wall strain and blood flow realized by high frame rate acouisition of RF echoes2008

    • Author(s)
      Hideyuki Hasegawa
    • Organizer
      IEEE 2008 International Ultrasonics Symposium
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-11-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Accurate Ultrasonic Measurement of Two-Dimensional Displacement of Heart Wall Motion for Estimation of Myocardial Regional Strain Rate2008

    • Author(s)
      Yasunori Honjo
    • Organizer
      Acoustics '08 Paris
    • Place of Presentation
      Paris, France
    • Year and Date
      2008-07-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Flow-Mediated Change in Viscoelasticity of Radial Arterial Wall Measured by 22-MHz Ultrasound2008

    • Author(s)
      Kazuki Ikeshita
    • Organizer
      Acoustics '08 Paris
    • Place of Presentation
      Paris, France
    • Year and Date
      2008-07-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ultrasonic Imaging of Displacements Inside Objects Induced by Continuously Applied Fluctuating Acoustic Radiation forces2008

    • Author(s)
      Hideyuki Hasegawa
    • Organizer
      Acoustics'08 Paris
    • Place of Presentation
      Paris, France
    • Year and Date
      2008-07-04
    • Related Report
      2008 Annual Research Report
  • [Book] Nano-Biomedical Engineering 20092009

    • Author(s)
      Takami Yamaguchi
    • Total Pages
      469
    • Publisher
      Imperial College Press
    • Related Report
      2009 Annual Research Report
  • [Book] Biomedical Applications of Vibration and Acoustics in Imaging and Characterizations2008

    • Author(s)
      Ahmed Al-Jumaily
    • Publisher
      ASME Press
    • Related Report
      2008 Annual Research Report
  • [Book] Acoustical Imaging2008

    • Author(s)
      Iwaki Akiyama
    • Publisher
      Springer
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.ecei.tohoku-ac.jp/~hkanai/index_j.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.ecei.tohoku.ac.jp/~hkanai/index_j.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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