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好塩基球と肥満細胞に選択的に発現する活性型受容体CD200R3のリガンド同定

Research Project

Project/Area Number 20659076
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

烏山 一  Tokyo Medical and Dental University, 医歯学総合研究科, 教授 (60195013)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2009: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2008: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords好塩基球 / マスト細胞 / CD200R3 / リガンド / 活性型受容体 / CD200
Research Abstract

CD200R3はCD200受容体(CD200R)ファミリーに属する細胞表面分子で、好塩基球とマスト細胞に選択的に発現している。CD200RはリガンドであるCD200を認識することにより、細胞内に抑制性シグナルを伝達するが、CD200R3はアダプター分子DAP12と会合して、細胞内に活性化シグナルを伝達する。CD200R3はCD200Rとともにペア型受容体として、好塩基球とマスト細胞を正ならびに負に制御していると考えられるが、CD200R3はCD200Rとは異なりCD200とは結合しない。したがって、CD200R3にはCD200とは別のリガンドが存在すると考えられる。昨年度作製した分泌型CD200R3をプローブとして、内在性ならびに外来性リガンドの検索をおこなったが、会合分子の同定には至っていない。一方、昨年度の研究で同定したCD200類似遺伝子をクローニングし、細胞に遺伝子導入したところ、細胞表面に蛋白質として表出することが判明した。そこで、この遺伝子導入細胞をラットに免疫して、B細胞ハイブリドーマを作製し、CD200とは反応せずCD200類似分子を特異的に認識するモノクローナル抗体を得た。この抗体を用いてCD200類似分子の発現パターンを調べたところ、ユビキタスな発現パターンを示すCD200とは異なり、ごく限られた臓器内のユニークな細胞に発現が限局していることが明らかとなった。現在、CD200Rファミリー分子との結合能ならびに生体内での役割を解析している。

Report

(2 results)
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (77 results)

All 2010 2009 2008 Other

All Journal Article (39 results) (of which Peer Reviewed: 16 results) Presentation (36 results) Remarks (2 results)

  • [Journal Article] The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner2010

    • Author(s)
      Nakata, K.
    • Journal Title

      Biochem.Biophys.Res.Commun. (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 急性ならびに慢性アレルギー発症における好塩基球の新たな役割2010

    • Author(s)
      鳥山一
    • Journal Title

      炎症と免疫 18

      Pages: 23-27

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 好塩基球が主役を演じるIgE依存性慢性アレルギー炎症2010

    • Author(s)
      鳥山一
    • Journal Title

      IgE practice in asthma

      Pages: 1-5

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome2009

    • Author(s)
      峯岸克行
    • Journal Title

      J.Exp.Med. 206

      Pages: 1291-1301

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The study of allergy by Japanese researchers : a historical perspective2009

    • Author(s)
      Takai, T.
    • Journal Title

      Int.Immunol. 21

      Pages: 1311-1316

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells2009

    • Author(s)
      Ugajin, T.
    • Journal Title

      J.Leukoc.Biol. 86

      Pages: 1417-1425

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性アレルギー炎症ならびにアナフィラキシーにおける好塩基球のあらたな役割2009

    • Author(s)
      鳥山一
    • Journal Title

      医学のあゆみ別冊「最新免疫研究Update」

      Pages: 77-82

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 好塩基球・マスト細胞の機能とCD200R32009

    • Author(s)
      小島利之
    • Journal Title

      臨床免疫アレルギー科 52

      Pages: 49-57

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 自己免疫現象と疾患発症2009

    • Author(s)
      鳥山一
    • Journal Title

      ひらかれた小児リウマチ診療(日本小児リウマチ学会)

      Pages: 13-16

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 高IgE症候群の原因遺伝子は何か2009

    • Author(s)
      峯岸克行
    • Journal Title

      分子リウマチ治療

      Pages: 19-20

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 好塩基球とアレルギー2009

    • Author(s)
      向井香織
    • Journal Title

      日本臨床 67

      Pages: 2095-2099

    • Related Report
      2009 Annual Research Report
  • [Journal Article] アレルギーにおける好塩基球の新たな役割2009

    • Author(s)
      鳥山一
    • Journal Title

      実験医学増刊「アレルギー疾患の免疫機構」 27

      Pages: 68-74

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Newly-discovered roles for basophils : a neglected minority gains newrespect.2009

    • Author(s)
      Karasuyama, H.
    • Journal Title

      Nat. Rev. Immunol. 9

      Pages: 9-13

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fc receptor r-chain, a constitutive component of the interleukin 3 receptor is required for interleukin 3-induced interleukin 4.2009

    • Author(s)
      Hida, S.
    • Journal Title

      Nat. Immunol. 10

      Pages: 214-222

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver.2009

    • Author(s)
      Yoshikawa, S.
    • Journal Title

      Int. Immunol. 21

      Pages: 43-52

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New insights into the roles for basophils in acute and chronic allergy2009

    • Author(s)
      Mukai, K.
    • Journal Title

      Allergol. Int. 58

      Pages: 11-19

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome : lessons from a primary human immunodeficiency.2009

    • Author(s)
      Minegishi, Y.
    • Journal Title

      Int. Immunol. 21

      Pages: 105-112

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peanuts can contribute to anaphylactic shock by activating complement.2009

    • Author(s)
      Khodoun, M.
    • Journal Title

      J. Allergy Clin. Immunol. 58

      Pages: 11-19

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.2009

    • Author(s)
      Belkina N. V.
    • Journal Title

      Proc. Natl Acad. Sci. USA. 106

      Pages: 4707-4712

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アレルギーにおける好塩基球の新たな役割2009

    • Author(s)
      烏山 一
    • Journal Title

      Annual Review 2009呼吸器(中外医学社)

      Pages: 44-51

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 免疫アレルギー研究の表舞台に躍り出た好塩基球2009

    • Author(s)
      烏山 一
    • Journal Title

      アレルギー・免疫 16(3)

      Pages: 9-10

    • Related Report
      2008 Annual Research Report
  • [Journal Article] CD200R3を介した好塩基球とマスト細胞の活性化2009

    • Author(s)
      小島利之
    • Journal Title

      アレルギー・免疫 16(3)

      Pages: 44-51

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 好塩基球によるIgG型アナフィラキシーの誘導2009

    • Author(s)
      辻村祐佑
    • Journal Title

      アレルギー・免疫 16(3)

      Pages: 62-71

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 好塩基球が主役を演じる慢性アレルギー炎症2009

    • Author(s)
      向井香織
    • Journal Title

      アレルギー・免疫 16(3)

      Pages: 72-77

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Basophils play a pivotal role in immunoglobulin G- but not immunoglobulin E-mediated systemic anaphylaxis.2008

    • Author(s)
      Tsujimura, Y.
    • Journal Title

      Immunity 28

      Pages: 581-589

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erk kinases link pre-B cell receptor signaling to transcriptional eventsrequired for early B cell expansion.2008

    • Author(s)
      Yasuda, T.
    • Journal Title

      Immunity 28

      Pages: 499-508

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic origins of hyper-IgE syndrome.2008

    • Author(s)
      Minegishi, Y.
    • Journal Title

      Curr. Allergy Asthma Rep. 8(5)

      Pages: 386-391

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overproduction of IgE induces macrophage-derived chemokine (CCL22)secretion from basophils.2008

    • Author(s)
      Watanabe, M.
    • Journal Title

      J. Immunol. 181

      Pages: 5653-5659

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel hairless mouse model on an atopic dermatitis-prone genetic background generated by receptor-mediated transgenesis.2008

    • Author(s)
      Takada, T.
    • Journal Title

      Transgenic Res. 17(6)

      Pages: 1155-1162

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アレルギー疾患関連遺伝子〜サイトカイン・シグナル伝達分子(Tyk2, STAT3)の遺伝子変異による高IgE症候群の発症〜2008

    • Author(s)
      峯岸克行
    • Journal Title

      感染炎症免疫 38(1)

      Pages: 24-31

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 皮膚アレルギーと好塩基球2008

    • Author(s)
      横関博雄
    • Journal Title

      皮膚アレルギーフロンティア 6(2)

      Pages: 118-125

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 好塩基球の2 1世紀ルネサンス〜生体内における好塩基球のユニークな役割が次々と明らかに〜2008

    • Author(s)
      辻村祐佑
    • Journal Title

      臨床血液 49(7)

      Pages: 489-497

    • Related Report
      2008 Annual Research Report
  • [Journal Article] STAT3シグナルと免疫疾患2008

    • Author(s)
      峯岸克行
    • Journal Title

      実験医学増刊「シグナル伝達研究」実験医学 26(15)

      Pages: 132-136

    • Related Report
      2008 Annual Research Report
  • [Journal Article] アナフィラキシー・ショックを引き起こす新たな仕組み-好塩基球の知られざる役割が明らかに2008

    • Author(s)
      烏山 一
    • Journal Title

      Dental Diamond 33

      Pages: 66-70

    • Related Report
      2008 Annual Research Report
  • [Journal Article] アナフィラキシー・ショックを引き起こす新たなメカニズムー好塩基球・IgG ・ 血小板活性化因子を介した即時型アレルギー2008

    • Author(s)
      辻村祐佑
    • Journal Title

      細胞工学 27(10)

      Pages: 1030-1031

    • Related Report
      2008 Annual Research Report
  • [Journal Article] アナフィラキシーショック発症の新たなメカニズム2008

    • Author(s)
      鳥山 一
    • Journal Title

      日本医事新報 4402

      Pages: 45-48

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 危険なアレルギー反応の新たな仕組みが明らかに2008

    • Author(s)
      烏山 一
    • Journal Title

      科学(岩波書店) 78(11)

      Pages: 1246-1251

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 慢性アレルギー炎症ならびにアナフィラキシーにおける好塩基球のあらたな役割2008

    • Author(s)
      烏山 一
    • Journal Title

      医学のあゆみ 227(5)

      Pages: 361-366

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 好塩基球とマスト細胞に発現するCD200R32008

    • Author(s)
      小畑一茂
    • Journal Title

      臨床免疫・アレルギー科 50(5)

      Pages: 595-602

    • Related Report
      2008 Annual Research Report
  • [Presentation] Newly discovered roles for basophils in allergy and parasitic infections2010

    • Author(s)
      鳥山一
    • Organizer
      US-Japan Joint Symposium : Adaptive and innate immune responses to neglected tropical diseases conference
    • Place of Presentation
      San Diego, USA.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Previously unrecognized roles for basophils in immune and allergic responses(招待講演)2010

    • Author(s)
      鳥山一
    • Organizer
      3^<rd> International Singapore symposium of immunology
    • Place of Presentation
      Singapore
    • Related Report
      2009 Annual Research Report
  • [Presentation] アレルギーにおける好塩基球の二面性:悪玉細胞それとも善玉細胞?(招待講演)2009

    • Author(s)
      鳥山一
    • Organizer
      第28回漢方免疫アレルギー研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] アレルギーならびに生体防御における好塩基球の新たな役割(招待講演)2009

    • Author(s)
      鳥山一
    • Organizer
      第5回金沢小児・皮膚免疫アレルギー研究会
    • Place of Presentation
      金沢
    • Year and Date
      2009-06-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高IgE症候群の責任遺伝子の同定と病態解明(招待講演)2009

    • Author(s)
      鳥山一、峯岸克行
    • Organizer
      第3回千葉小児皮膚免疫アレルギー研究会
    • Place of Presentation
      千葉
    • Year and Date
      2009-05-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role for basophils in IgG but not IgE-mediated systemic anaphylaxis(招待講演)2009

    • Author(s)
      鳥山一
    • Organizer
      First Croatian Congdress of Allergology and Clinical Immunology
    • Place of Presentation
      Zagreb, Croatia
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome(招待講演)2009

    • Author(s)
      鳥山一
    • Organizer
      First Croatian Congdress of Allergology and Clinical Immunology
    • Place of Presentation
      Zagreb, Croatia
    • Related Report
      2009 Annual Research Report
  • [Presentation] Newly discovered roles for basophils : a neglected minority gains new respect(招待講演)2009

    • Author(s)
      鳥山一
    • Organizer
      6^<th> Biennial Symposium International Eosinophil Society(Eosinophil 2009)
    • Place of Presentation
      Bruges, Belgium
    • Related Report
      2009 Annual Research Report
  • [Presentation] Basophils play an important role in the resolution of inflammation by inducing alternative activation of macrophages through Th2 cytokine release2009

    • Author(s)
      鳥山一
    • Organizer
      2nd European Congress of Immunology(ECI 2009)
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2009 Annual Research Report
  • [Presentation] Basophils play a possible immunoregulatory role during Schistosoma mansoni infection in mice.2009

    • Author(s)
      William Anyan K.
    • Organizer
      58^<th> Annual Meeting of American Society of Tropical Medicine and Hygiene
    • Place of Presentation
      Washington DC. USA.
    • Related Report
      2009 Annual Research Report
  • [Presentation] 好塩基球と生体防御(招待講演)2009

    • Author(s)
      鳥山一
    • Organizer
      第20回日本生体防御学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] アレルギーにおける好塩基球の二面性:悪玉細胞それとも善玉細胞?(招待講演)2009

    • Author(s)
      鳥山一
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Related Report
      2009 Annual Research Report
  • [Presentation] アレルギー疾患における好塩基球の役割2009

    • Author(s)
      鳥山一
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Related Report
      2009 Annual Research Report
  • [Presentation] Novel roles for basophils in allergy2009

    • Author(s)
      鳥山一
    • Organizer
      第59回日本アレルギー学会秋季学術大会International Symposium
    • Place of Presentation
      秋田
    • Related Report
      2009 Annual Research Report
  • [Presentation] 好塩基球による皮膚慢性アレルギーの誘導と炎症終焉(招待講演)2009

    • Author(s)
      鳥山一
    • Organizer
      第39回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dyanamics of basophil behavior in immune and allergic responses : in vivo imaging analysis using basophil-specific GFP mice.2009

    • Author(s)
      Yoshikawa, S.
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dominant negative mutation in STAT3 results in defective osteoblast and osteoclast function in hyper-IgE syndrome2009

    • Author(s)
      峯岸克行
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Establishment of diphtheria toxin based in vivo deletion system of basophils and mast cells.2009

    • Author(s)
      Sawaguchi, M.
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Basophils play an important role in the acquisition of resistance to infections with nematodes2009

    • Author(s)
      Obata, K.
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role for basophils in the development of resistance to external para sites2009

    • Author(s)
      Wada, T.
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] The generation of induced Treg(iTreg)but not naturally occurring Treg(nTreg)is impaired in the hyper IgE syndrome2009

    • Author(s)
      Saito, M.
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Importance of the subclass and oligoclonality of IgG for efficient inducton of systemic anaphylaxis2009

    • Author(s)
      Ishikawa, R.
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] A novel mechanism for the autonomous termination of pre-B cell receptor expression through BLINK-mediated induction of LAPTM52009

    • Author(s)
      Kawano, Y.
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Basophils regulate macrophage functions through Th2 cytokines in allergic inflammation.2009

    • Author(s)
      Karasuyama, H.
    • Organizer
      Keystone Symposia 'Allergy and Asthma'.
    • Place of Presentation
      Keystone, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] 見逃されていた好塩基球の重要性2008

    • Author(s)
      烏山 一
    • Organizer
      第36回日本臨床免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高IgE症候群の分子基盤2008

    • Author(s)
      峯岸克行
    • Organizer
      第3 6回日本臨床免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] アトピー性皮膚炎を伴うユニークな免疫不全症「高IgE症候群」の責任遺伝子と病態の解明2008

    • Author(s)
      烏山 一
    • Organizer
      生体機能と創薬シンポジウム2008
    • Place of Presentation
      東京
    • Year and Date
      2008-08-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 好塩基球の2 1世紀ルネサンス〜好塩基球の生体内でのユニークな役割の解明〜2008

    • Author(s)
      烏山 一
    • Organizer
      四国免疫フォーラム
    • Place of Presentation
      高知
    • Year and Date
      2008-06-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Basophils and mast cells play distinct roles in acute and chronic allergic reactions.2008

    • Author(s)
      Karasuyama, H.
    • Organizer
      27^<th> Symposium of the Collegium InternationalAllergologicum.
    • Place of Presentation
      Curacao
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chronic cutaneous allergic inflammation - responsible cells and causative genes.2008

    • Author(s)
      Karasuyama, H.
    • Organizer
      International Investigative Dermatology 2008.
    • Place of Presentation
      Kyoto
    • Related Report
      2008 Annual Research Report
  • [Presentation] Roles of mast cells and basophils in the development of allergic diseases.2008

    • Author(s)
      Karasuyama, H.
    • Organizer
      Frontiers in Allergy and Autoimmunity.
    • Place of Presentation
      Mainz, Germany
    • Related Report
      2008 Annual Research Report
  • [Presentation] Basophils and mast cells play distinct roles in acute and chronic allergic responses.2008

    • Author(s)
      Karasuyama, H.
    • Organizer
      FOCIS (Federation of Clinical Immunology Societies)2008.
    • Place of Presentation
      Boston, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Hyper-IgE syndrome is a compound primary immunodeficiency caused by the signalopathy of multiple cytokines.2008

    • Author(s)
      Minegishi, Y.
    • Organizer
      RCAI-JSI International Symposium.
    • Place of Presentation
      Yokahama
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生体防御ならびにアレルギー疾患における好塩基球のユニークな役割2008

    • Author(s)
      烏山 一
    • Organizer
      第3 2回阿蘇シンポジウム
    • Place of Presentation
      熊本
    • Related Report
      2008 Annual Research Report
  • [Presentation] The role for basophils in the protection against external parasites.2008

    • Author(s)
      Karasuyama, H.
    • Organizer
      The 8^<th> Awaji International Forum on Infectionand Immunity.
    • Place of Presentation
      Awaji
    • Related Report
      2008 Annual Research Report
  • [Presentation] 特別講演「好塩基球の2 1世紀ルネサンス〜急性ならびに慢性アレルギーにおける好塩基球の新たな役割」2008

    • Author(s)
      烏山 一
    • Organizer
      第5 8回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/mbch/top_Japanese.htm

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/mbch/top_Japanese.htm

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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