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先祖帰り制御因子Notch ligand操作による脳虚血後神経再生促進法の開発

Research Project

Project/Area Number 20659242
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionGunma University

Principal Investigator

齋藤 繁  群馬大学, 大学院・医学系研究科, 教授 (40251110)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2010: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2009: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2008: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywords再生医学 / 神経幹細胞 / Notch ligand / Notch liand
Research Abstract

脳虚血の予防法を体外からの非侵襲的手法に依って判定する技術を開発改良して発表した。また、脳虚血が生じた場合に、その程度を如何に軽度にとどめ、早期に回復を促進するかについて検討を進めているが、特に、動脈硬化性疾患や糖尿病など、生活習慣病として広く社会において罹病率の高い疾患にフォーカスを当て、検討した。臨床の現場においては、予防的な対策が採れる場合は限定的であるので、予め、リスクの高い集団を特定する技術は有効と考えられる。一方、一度確立した神経障害に対して、保存的な処置やリハビリテーション的な管理を超えた治療法、再生促進法が可能であるか、神経伝達物資や栄養因子の関連を検討しながら、研究を進めた。栄養因子については既に臨床で使用可能である二つの栄養因子、インスリン様栄養因子と線維芽細胞増殖因子について単独投与、同時投与の効果を判定した。両者は相乗的とは言えないが、相加的に神経細胞の再生を促進することが確認された。今後、成熟脳やその他の成熟神経組織においても存在する未分化な細胞を合目的に誘導分化させる方法を開発することを目指して、神経障害後など神経組織の修復が必要な状況で、内因性に活性化され再生促進に寄与する可能性が示唆されているその他の因子と神経幹細胞などにフォーカスを当て更に臨床応用に向けた研究を進展させる予定である。先祖帰り制御因子Notch ligand操作による再生促進も栄養因子と相まって、効果を現すものと考えられる。一方、神経伝達物質の過剰や不足も神経細胞の破壊ならびに再生に大きく影響を与えることが指摘されているので、今回の研究でも、特に抑制性神経伝達物質の動態に関して、遺伝子改変動物を用いて検討し、神経機能への重要な関与を同定した。

Report

(3 results)
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (20 results)

All 2011 2010 2009 2008

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Preoperative depression is a risk factor for postoperative short-term and long-term cognitive dysfunction in patients with diabetes mellitus.2011

    • Author(s)
      Kadoi Y
    • Journal Title

      J Anesth.

      Volume: 25 Pages: 10-17

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of astrocytes in the spinal cord contributes to the development of bilateral allodynia after peripheral nerve injury in rats.2010

    • Author(s)
      Obata H
    • Journal Title

      Brain Res.

      Volume: 1363 Pages: 72-80

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats.2010

    • Author(s)
      Obata H
    • Journal Title

      J Pharmacol Exp Ther.

      Volume: 334 Pages: 1059-1065

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential effects of hyperventilation on cerebral blood flow velocity after tourniquet deflation during sevoflurane, isoflurane, or propofol anesthesia.2010

    • Author(s)
      Hinohara H
    • Journal Title

      J Anesth.

      Volume: 24 Pages: 587-593

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblast growth factor and insulin-like growth factor rescue growth cones of sensory neurites from collapse after tetracaine-induced iniurv.2010

    • Author(s)
      Seki T
    • Journal Title

      Anesth Analg.

      Volume: 110 Pages: 1468-1472

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the effects of vasopressin and norepinephrine on organ perfusion during septic shock in streptozotocin-induced diabetic rats.2010

    • Author(s)
      Hinohara H
    • Journal Title

      J Anesth.

      Volume: 24 Pages: 553-563

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Normal glucose enhances neuronal regeneration after lidocaine-induced injury2010

    • Author(s)
      Abdel Nazeer A
    • Journal Title

      Br J Anaesth.

      Volume: 104 Pages: 482-486

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible indications of beta-blockers in the perioperative period other than prevention of cardiac ischemia2010

    • Author(s)
      Kadoi
    • Journal Title

      J Anesth

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between cardiac output and onset of succinylcholine chloride action in electroconvulsive therapy patients2009

    • Author(s)
      Matsumoto N
    • Journal Title

      J ECT Vol.25(4)

      Pages: 246-249

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The comparative effects of equipotent Bispectral Index dosages of propofol and sevoflurane on cerebrovascular carbon dioxide reactivity in elderly patients2009

    • Author(s)
      Kadoi Y
    • Journal Title

      J Clin Anesth Vol.21(3)

      Pages: 173-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mizutani A. Differential increases in blood flow velocity in the middle cerebral artery after tourniquet deflation during sevoflurane, isoflurane or propofol anaesthesia2009

    • Author(s)
      Kadoi Y
    • Journal Title

      Anaesth Intensive Care Vol.37(4)

      Pages: 598-603

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus under sedative doses of propofol.2008

    • Author(s)
      Kawauchi C, Kadoi Y, Hinohara H, Kunimoto F, Saito S.
    • Journal Title

      Journal of Anesthesia 22

      Pages: 429-434

    • NAID

      10024460901

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The comparative effects of sevoflurane versus isoflurane on cerebrovas cular carbon dioxide reactivity in patients with previous stroke.2008

    • Author(s)
      Kadoi Y, Saito S, Takahashi K.
    • Journal Title

      Journal of Anesthesia 22

      Pages: 135-139

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the cannabinoid antagonist AM281 on systemic hemodynamics and mortality rate in streptozotocin-induced diabetic rats with endotoxic shock: comparison between non-diabetic and diabetic rats.2008

    • Author(s)
      Kadoi Y, Hinohara H, Kunimoto F, Saito S.
    • Journal Title

      Acta Anaesthesiolica Scandinavica 52

      Pages: 664-672

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel bFGF-GH injection therapy for two patients with severe ischemic limb pain.2008

    • Author(s)
      Ito N, Saito S, Yamada MH, Koizuka S, Obata H, Nishikawa K, Tabata Y.
    • Journal Title

      Journal of Anesthesia 22

      Pages: 449-452

    • NAID

      10024460980

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth cone collapse and neurite retractions: an approach to examine X-irradiation affects on neuron cells.2008

    • Author(s)
      Al-Jandari WS, Suzuki Y, Yoshida Y,. Noda SE, Shirai K, Saito S, Goto F, Nakano T.
    • Journal Title

      J Radiat Res (Tokyo). 49

      Pages: 481-489

    • NAID

      110006935554

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Antihypersensitivity effects of tramadol hydrochloride in a rat model of postoperativepain2010

    • Author(s)
      Kimura M
    • Organizer
      Society for Neuroscience Annual Meeting 2010
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 塩酸トラマドールの鎮痛作用機序 -ラット術後痛モデルとマイクロダイアリシスでの検討-2010

    • Author(s)
      木村雅文
    • Organizer
      第32回日本疼痛学会
    • Place of Presentation
      京都市
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミルナシプランおよびパロキセチンの鎮痛メカニズム2010

    • Author(s)
      中島邦枝
    • Organizer
      日本麻酔科学会第57回学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Book] CTガイド下神経ブロック2011

    • Author(s)
      齋藤繁
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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