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ニューロイメージング法を用いた咬合と全身機能の脳神経生理学的解析

Research Project

Project/Area Number 20659322
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

小野 卓史  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (30221857)

Co-Investigator(Kenkyū-buntansha) 誉田 栄一  徳島大学, ヘルスバイオサイエンス研究部, 教授 (30192321)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2009: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2008: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords咬合 / 運動機能 / 随意咬みしめ / 上肢筋 / fMRI / 脳賦活パタン / 脳機能 / 機能的磁気共鳴画像法 / 筋活動 / 同時記録 / タッピング運動 / 咀嚼 / 舌 / 習慣性咀嚼側 / 脳活動 / 2点弁別試験
Research Abstract

歯科やスポーツ分野において、咬合と全身の運動機能との関係が注目を集めており、随意的な咬みしめに伴って全身の運動機能が促進されるということが数多く報告されている。これまでの研究で咬みしめによる運動機能の向上は下位中枢である脊髄の関与が多くの研究で言われているが、上位中枢の関与は不明であった。近年、大脳皮質一次運動野の磁気刺激により骨格筋から運動誘発電位を記録した研究で、咬みしめにより電位の振幅が増大したことから、上肢筋筋力の咬みしめによる促通には脳すなわち上位中枢が関与していると考えられるようになってきた。しかしながら、咬みしめが脳機能にいかなる影響を与えるか、咬合と全身機能の関連において脳はいかなる役割を果たしているかに関しては未だ解明されていない。そこで本研究で我々は、咬みしめが上肢筋筋力に与える影響をfMRIを利用し、脳賦活パタンを指標として検討した。被験者は東京医科歯科大学歯学部在学中の学生及び、当分野医局員のうち定期的な筋力トレーニングを行っておらず、上前腕部障害の既往、歯痛、口腔顔面領域の筋肉痛および顎関節痛のない個性正常咬合を有する健康成人10名とした。MRI室外にて、被験者に利き手で握力計を把持させ、咬頭嵌合位で咬みしめながらの瞬発的把持動作と下顎安静位での瞬発的把持動作を2秒間行わせ、握力を測定した。脳機能画像の採得に際して、被験者は瞬発的把持動作、および咬頭嵌合位での咬みしめ動作を行った、把持動作のみを行った場合に比較し、咬みしめ動作と同時に把持動作を行った場合の方が、感覚運動野のうち手に関する領域および補足運動野の活動領域および活動強度が有意に増加した。以上のことから、上肢筋筋力の咬みしめによる促通には上位中枢が関与しており、そのうち感覚運動野および補足運動野が咬みしめによる運動能力の向上に関連があることが示唆された。

Report

(3 results)
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2011 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (20 results) Book (1 results)

  • [Journal Article] Application of MRI movie for observation of articulatory movement during africative /s/ and a plosive /t/ : Tooth visualization in MRI.2011

    • Author(s)
      Ng IW, Ono T, et al.
    • Journal Title

      Angle Orthod

      Volume: 81 Pages: 237-244

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 咬合異常からみた舌機能の意義2010

    • Author(s)
      小野卓史
    • Journal Title

      口病誌

      Volume: 77 Pages: 163-168

    • NAID

      10027446939

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Motor coordination of articulators depends on the place of articulation2009

    • Author(s)
      Inoue-Arai MS, et al.
    • Journal Title

      Behav Brain Res 199

      Pages: 307-316

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preferred-chewing-side-dependent two-point discrimination and cortical activation pattern of tactile tongue sensation2009

    • Author(s)
      Minato A, et al.
    • Journal Title

      Behav Brain Res 203

      Pages: 118-126

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Dilemma in skeletal Class III treatment : functional considerations from respiratory perspectives.2011

    • Author(s)
      Ono T
    • Organizer
      The 4th Class III Symposium
    • Place of Presentation
      Seoul
    • Year and Date
      2011-02-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Orofacial function/dysfunction viewed from clinical neurophysiological perspectives.2011

    • Author(s)
      Ono T
    • Organizer
      Special Seminar at Capital Medical University
    • Place of Presentation
      Beijing
    • Year and Date
      2011-01-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Orofacial function/dysfunction viewed from clinical neurophysiological perspectives2011

    • Author(s)
      Ono T
    • Organizer
      Special Seminar at Pekin University
    • Place of Presentation
      Beijing
    • Year and Date
      2011-01-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経生理学・臨床生理学と歯科医学の接点2010

    • Author(s)
      小野卓史
    • Organizer
      平成22年度第3回個体差研セミナー
    • Place of Presentation
      当別
    • Year and Date
      2010-10-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経生理学・臨床生理学と歯科矯正学の接点.2010

    • Author(s)
      小野卓史
    • Organizer
      口腔病学会5月例会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of preferred chewing side in two-point discrimination and cortical activation of tactile tongue sensation.2010

    • Author(s)
      Minato A, Ono T, et al.
    • Organizer
      2nd International Conference on Orthodontic Treatment
    • Place of Presentation
      Hiroshima
    • Related Report
      2010 Annual Research Report
  • [Presentation] Simultaneous functional magnetic resonance imaging- electromyographic measurement during tooth tapping.2010

    • Author(s)
      Miyamoto JJ, Hanakawa T, Ono T, et al.
    • Organizer
      86^<th> Congress of the European Orthodontic Society
    • Place of Presentation
      Portoroz
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cortical activity during tooth tapping tasks : a preliminary study.2010

    • Author(s)
      Miyamoto JJ, Hanakawa T, et al.
    • Organizer
      88^<th> International Association for Dental Research
    • Place of Presentation
      Barcelona
    • Related Report
      2010 Annual Research Report
  • [Presentation] Tooth visualization in MRI movie for evaluation of articulatory movements.2010

    • Author(s)
      Ng IW, Ono T, et al.
    • Organizer
      88^<th> International Association for Dental Research
    • Place of Presentation
      Barcelona
    • Related Report
      2010 Annual Research Report
  • [Presentation] An application of MRI technology to analyze oral/pharyngeal morphology and function in orthodontic/craniofacial patients.2010

    • Author(s)
      Ono T
    • Organizer
      33rd Annual Scientific Meeting of the Association for Dental Sciences of the Republic of China (ADS-ROC)
    • Place of Presentation
      Taipei
    • Related Report
      2010 Annual Research Report
  • [Presentation] Relationship between buccolingual position and angle of molars and intraoral pressure in subjects with facial asymmetry2009

    • Author(s)
      Takada J, et al.
    • Organizer
      85^<th> Congress of the European Orthodontic Society
    • Place of Presentation
      Helsinki
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mandibular hinge axis in skeletal Class III subjects with posterior unilateral crossbite2009

    • Author(s)
      Yokota T, et al.
    • Organizer
      85^<th> Congress of the European Orthodontic Society
    • Place of Presentation
      Helsinki
    • Related Report
      2009 Annual Research Report
  • [Presentation] Geometrical changes in the tongue shape during articulation in subjects with and without CLP revealed by MRI movie2009

    • Author(s)
      Inoue-Arai MS, et al.
    • Organizer
      11^<th> International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies
    • Place of Presentation
      Fortaleza
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mapping of brain activation areas in covert and overt articulation in subjects with and without cleft lip and palate2009

    • Author(s)
      Inoue-Arai MS, et al.
    • Organizer
      11^<th> International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies
    • Place of Presentation
      Fortaleza
    • Related Report
      2009 Annual Research Report
  • [Presentation] An application of MRI technology to analyze speech-related central/peripheral function in cleft lip/palate2009

    • Author(s)
      Ono T
    • Organizer
      11^<th> International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies
    • Place of Presentation
      Fortaleza
    • Related Report
      2009 Annual Research Report
  • [Presentation] Avaliacao da Articulacao da Fala Utilizando RMfuncional e RMmovie em Pacientes Fissurado e Nao Fissurado2009

    • Author(s)
      Inoue-Arai MS, et al.
    • Organizer
      7th ABOR(Associacao Brasileira de Ortodontia e Ortopedia Facial)
    • Place of Presentation
      Brasilia-DF・Brasil
    • Related Report
      2009 Annual Research Report
  • [Presentation] 舌感覚の皮質投射パタンにおける習慣性咀嚼側の関与2009

    • Author(s)
      湊亜紀子, ほか
    • Organizer
      第68回日本矯正歯科学会大会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] 破裂音発音時における舌の形状および重心の構音点依存性の経時的変化2009

    • Author(s)
      井上マリステラ小百合, ほか
    • Organizer
      第68回日本矯正歯科学会大会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] Preferred-chewing-side-dependent two-point discrimination and cortical activation of tactile tongue sensation2008

    • Author(s)
      Minato A, et al.
    • Organizer
      56^<th> Japanese Association for Dental Research
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] 舌に対する2点弁別試験および触覚刺激に伴う大脳皮質一次体性感覚野の賦活パタンの解析‐習慣性咀嚼側との関連‐2008

    • Author(s)
      湊亜紀子, 他
    • Organizer
      第73回口腔病学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Book] 睡眠学【頭部X線規格写真(セファロ)分析】2009

    • Author(s)
      小野卓史
    • Total Pages
      760
    • Publisher
      朝倉書店
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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