Activity-dependent mechanisms regulating dendriticmorphology and function

• Project/Area Number: 20670002
• Research Category: Grant-in-Aid for Young Scientists (S)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: The University of Tokyo
• Principal Investigator: BITO Haruhiko 東京大学, 大学院・医学系研究科, 准教授 (00291964)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥104,780,000 (Direct Cost: ¥80,600,000、Indirect Cost: ¥24,180,000); Fiscal Year 2012: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000); Fiscal Year 2011: ¥29,640,000 (Direct Cost: ¥22,800,000、Indirect Cost: ¥6,840,000); Fiscal Year 2010: ¥29,640,000 (Direct Cost: ¥22,800,000、Indirect Cost: ¥6,840,000); Fiscal Year 2009: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000); Fiscal Year 2008: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
• Keywords: カルシウム / リン酸化 / 突起伸展 / シナプスから核へのシグナリング / 脳・神経 / 発生・分化 / 遺伝子 / シグナル伝達 / 生体分子

Research Abstract

Molecular mechanisms underlying experience-dependent information processing and storage have remained elusive. Here, in this research program, we have uncovered novel molecular insights on (1)the role of CaMKK-CaMK cascade in neurite morphogenesis, (2) the signaling cascade that triggers new gene expression upon receipt of synaptic activity, and (3)a new inverse synaptic tagging mechanism that mediates specific forms of synaptic modulation upon activity-dependent gene expression. These findings shed new lights on the machinery that transforms and stores information about previous experience within the neural circuits.

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Research Products

• [Journal Article] Nonlinear Decoding and Asymmetric Representation of Neuronal Input Information by CaMKIIα and Calcineurin (2013)
  • Author(s): Fujii H, Inoue M, Okuno H, Sano Y; Takemoto-Kimura S, Kitamura K, Kano M, Bito H.
  • Journal Title: Cell Reports Volume: 3 Issue: 4 Pages: 978
  • DOI: 10.1016/j.celrep.2013.03.033
  • Peer Reviewed
• [Journal Article] The Immediate Early Gene Arc/Arg3.1 Is a Postsynaptic Mediator of Activity-Dependent Synapse Elimination in the Developing Cerebellum (2013)
  • Author(s): Mikuni T. et al.
  • Journal Title: Neuron Volume: 未定
  • Peer Reviewed
• [Journal Article] Executive Function Deficits and Social-Behavioral Abnormality in Mice Exposed to a Low Dose of Dioxin In Utero and via Lactation (2012)
  • Author(s): Endo T, Kakeyama M, Uemura Y, Haijima A, Okuno H, Bito H, Tohyama C
  • Journal Title: PLOS ONE Volume: 7 Issue: 12 Pages: e50741-e50741
  • DOI: 10.1371/journal.pone.0050741
  • Peer Reviewed
• [Journal Article] An inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKII ss (2012)
  • Author(s): Okuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF, Bito H
  • Journal Title: Cell Volume: 149 Pages: 886-898
  • Peer Reviewed
• [Journal Article] Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKllβ (2012)
  • Author(s): 奥野浩行, 他
  • Journal Title: Cell Volume: 149 Issue: 4 Pages: 886-898
  • DOI: 10.1016/j.cell.2012.02.062
  • Peer Reviewed
• [Journal Article] Visualization of the cortical projection neurons by retrograde TET-OFF lentiviral vector. (2012)
  • Author(s): 渡我部昭哉, 他
  • Journal Title: PLos One Volume: 7 Issue: 10 Pages: e46157-e46157
  • DOI: 10.1371/journal.pone.0046157
  • Peer Reviewed
• [Journal Article] Plasmodium induced by SU6656, an Src family kinase inhibitor, is accompanied by a contractile ring defect (2012)
  • Author(s): Yoshida K, Ono M, Bito H, Mikami T, Sawada H
  • Journal Title: Cell Biochem.Funct. Volume: (未定)(掲載確定)(印刷中) Issue: 1 Pages: 33-40
  • DOI: 10.1002/cbf.1814
  • Peer Reviewed
• [Journal Article] Calpain-mediated degradation of myocyte enhancer factor 2D contributes to excitotoxicity by activation of extrasynaptic NMDA receptors (2012)
  • Author(s): Wei G, Yin Y, Li W, Bito H, She H, Mao Z
  • Journal Title: Journal of Biological Chemistry Volume: (未定)(掲載確定)(印刷中) Issue: 8 Pages: 5797-5805
  • DOI: 10.1074/jbc.m111.260109
  • Peer Reviewed
• [Journal Article] Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ (2012)
  • Author(s): Okuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF, Bito H
  • Journal Title: Cell Volume: (未定)(掲載確定)(印刷中)
  • Peer Reviewed
• [Journal Article] Schema-dependent gene activation and memory encoding in neocortex (2011)
  • Author(s): Tse D, Takeuchi T, Kakeyama M, Kajii Y, Okuno H, Tohyama C, Bito H, MorrisRGM
  • Journal Title: Science Volume: 333 Pages: 891-895
  • Peer Reviewed
• [Journal Article] Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling method (2011)
  • Author(s): Komatsu T, Johnsson K, Okuno H, Bito H, Inoue T, Nagano T, Urano Y
  • Journal Title: J. Am. Chem. Soc Volume: 133 Issue: 17 Pages: 6745-6751
  • DOI: 10.1021/ja200225m
  • Peer Reviewed
• [Journal Article] Suppression of bone formation by osteoclastic expression of semaphorin 4D (2011)
  • Author(s): Negishi-Koga T, Shinohara M, Komatsu N, Bito H, Kodama T, Friedel RH, Takayanagi H
  • Journal Title: Nature Medicine Volume: 17 Issue: 11 Pages: 1473-1480
  • DOI: 10.1038/nm.2489
  • Peer Reviewed
• [Journal Article] Ca2+ signaling coordinates the formation and the morphological maturation of neuronal circuits and synapses: an essential role for excitation-morphogenesis coupling via CaM kinases (2010)
  • Author(s): Takemoto-Kimura S, Suzuki K, Kamijo S, Ageta-Ishihara N, Fujii H, Okuno H, BitoH
  • Journal Title: Eur. J. Neurosci Volume: 32 Pages: 224-230
  • Peer Reviewed
• [Journal Article] The chemical biology of synapses and neuronal circuits (2010)
  • Author(s): Bito H
  • Journal Title: Nature Chem. Biol Volume: 6 Pages: 560-563
  • Peer Reviewed
• [Journal Article] Widespread transcription at neuronal activity-regulated enhancers (2010)
  • Author(s): Kim TK, Hemberg M, Gray JM, Costa AM, Bear DM, Wu J, Harmin DA, Laptewicz M, Barbara-Haley K, Kuersten S, Markenscoff-Papadimitriou E, Kuhl D, Bito H, Worley PF, Kreiman G,Greenberg ME
  • Journal Title: Nature Volume: 465 Pages: 182-187
  • Peer Reviewed
• [Journal Article] Synaptic tagging and capture: differential role of distinct calcium/calmodulin kinases in protein synthesis-dependent long-term potentiation (2010)
  • Author(s): Redondo RL, Okuno H, Spooner PA, Frenguelli BG, Bito H, Morris RGM
  • Journal Title: J. Neurosci Volume: 30 Pages: 4981-4989
  • Peer Reviewed
• [Journal Article] Ca^<2+> signaling coordinates the formation and the morphological maturation of neuronal circuits and synapses : an essential role for excitation-morphogenesis coupling via CaM kinases. (2010)
  • Author(s): Takemoto-Kimura S, Suzuki K, Kamijo S, Ageta-Ishihara N, Fujii H, Okuno H, Bito H.
  • Journal Title: Eur.J.Neurosci. 32 Pages: 224-230
  • Peer Reviewed
• [Journal Article] The chemical biology of synapses and neuronal circuits. (2010)
  • Author(s): Bito H.
  • Journal Title: Nature Chem.Biol. 6 Pages: 560-563
  • Peer Reviewed
• [Journal Article] Widespread transcription at neuronal activity-regulated enhancers. (2010)
  • Author(s): Kim TK, Hemberg M, Gray JM, Costa AM, Bear DM, Wu J, Harmin DA, Laptewicz M, Barbara-Haley K, Kuersten S, Markenscoff-Papadimitriou E, Kuhl D, Bito H, Worley PF, Kreiman G, Greenberg ME.
  • Journal Title: Nature 465 Pages: 182-187
  • Peer Reviewed
• [Journal Article] Synaptic tagging and capture : differential role of distinct calcium/calmodulin kinases in protein synthesis-dependent long-term potentiation. (2010)
  • Author(s): Redondo RL, Okuno H, Spooner PA, Frenguelli BG, Bito H, Morris RGM.
  • Journal Title: J.Neurosci. 30 Pages: 4981-4989
  • Peer Reviewed
• [Journal Article] Synaptic Activity-Responsive Element (SARE) : A unique genomicstructure with an unusual sensitivity to neuronal activity. (2010)
  • Author(s): Inoue M, Yagisfiita-Kyo N, Nonaka M, Kawashima T, Okuno H, Bito H
  • Journal Title: Commun.Integr.Biol. Volume: 3 Pages: 443-446
  • Peer Reviewed
• [Journal Article] Differentical roles for CaM kinases in mediating excitation-morphogenesis coupling during formation and maturation of neuronal circuits. (2010)
  • Author(s): Takemoto-Kimura S, Suzuki K, Kamijo S, Ageta-Ishihara N, Fujii H, Oktmo H, Bito H
  • Journal Title: Eur.J.Neurosci. Volume: 32 Pages: 224-230
  • Peer Reviewed
• [Journal Article] The chemical biology of synapses and neuronal circuits. (2010)
  • Author(s): Bito H
  • Journal Title: Nature Chem.Biol. Volume: 6 Pages: 560-563
  • Peer Reviewed
• [Journal Article] Widespread transcription at neuronal activity-regulated enhancers. (2010)
  • Author(s): Kim TK, Hemberg M, Gray JM, Costa AM, Bear DM, Wu J, Harmin DA, Laptewicz M, Barbara-Haley K, Kuersten S, Markenscoff-Papadimitriou E, Kuhl D, Bito H, Worley PF, Kreiman G, Greenberg ME.
  • Journal Title: Nature Volume: 465 Pages: 182-187
  • Peer Reviewed
• [Journal Article] Synaptic tagging and capture : differential role of distinct calcium/calmodulin kinases in protein s thesis-dependent long-term potentiation. (2010)
  • Author(s): Redondo RL, Okuno H, Spooner PA, Frenguelli BG, Bito H, Morris RGM.
  • Journal Title: J.Neurosci. Volume: 30 Pages: 4981-4989
  • Peer Reviewed
• [Journal Article] Synaptic tagging and capture : differential role of distinct calcium/calmodulin kinases in protein synthesis-dependent long-term potentiation. (2010)
  • Author(s): Redondo R, et al.
  • Journal Title: Journal of Neuroscience (掲載確定(In press))
  • Peer Reviewed
• [Journal Article] Regulation of cortical axon growth by a GABA-driven Ca2+/ calmodulin-dependent protein kinase cascade (2009)
  • Author(s): Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila TA, Mizuno H, Hirano T, Tagawa Y, Okuno H, Bito H
  • Journal Title: J. Neurosci Volume: 29 Pages: 13720-13729
  • Peer Reviewed
• [Journal Article] A synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons (2009)
  • Author(s): Kawashima T, Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S, Worley PF, Bito H
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 106 Pages: 316-321
  • Peer Reviewed
• [Journal Article] Regulation of cortical axon growth by a GABA-driven Ca^<2+>/calmodulin-dependent protein kinase cascade. (2009)
  • Author(s): Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila TA, Mizuno H, Hirano T, Tagawa Y, Okuno H, Bito H.
  • Journal Title: J.Neurosci. 29 Pages: 13720-13729
  • Peer Reviewed
• [Journal Article] A synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. (2009)
  • Author(s): Kawashima T, Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S, Worley PF, Bito H.
  • Journal Title: Proc.Natl.Acad.Sci.USA 106 Pages: 316-321
  • Peer Reviewed
• [Journal Article] Control of cortical axon elongation by a GABA-driven Ca^<2+>/calmodulin-dependent protein kinase cascade. (2009)
  • Author(s): Ageta-Ishihara N, et al.
  • Journal Title: Journal of Neuroscience 29 Pages: 13720-13729
  • Peer Reviewed
• [Journal Article] シナプスから核へのシグナリング:シナプス可塑性を長期化する分子機構. (2009)
  • Author(s): 奥野浩行, 他
  • Journal Title: 細胞工学 28 Pages: 894-899
• [Journal Article] シナプス長期可塑性の分子基盤. (2009)
  • Author(s): 井上昌俊, 他
  • Journal Title: Cognition and Dementia. 8 Pages: 177-182
• [Journal Article] A synaptic activity-responsive element in the Arc/Arg3.1 promoteres sential for synapse-to-nucleus signaling in activated neurons. (2009)
  • Author(s): Kawashima
  • Journal Title: Proc. Natl, Acad. Sci. USA 106 Pages: 316-321
  • Peer Reviewed
• [Presentation] The role of Arc in inverse tagging of inactive synapses (2013)
  • Author(s): Bito H
  • Organizer: 25th Winter Conference on Neural Plasticity
  • Place of Presentation: Curacao, Netherlands.
  • Year and Date: 2013-02-10
• [Presentation] New roles of CaMKII in information storage and processing (2013)
  • Author(s): Bito H
  • Organizer: 46thWinter Conference on Brain Research
  • Place of Presentation: Breckenridge, Colorado, USA.
  • Year and Date: 2013-01-29
• [Presentation] New roles of CaMKII in information storage and processing. (2013)
  • Author(s): Haruhiko Bito
  • Organizer: 46th Winter Conference on Brain Research
  • Place of Presentation: Breckenridge, Colorado, USA
  • Invited
• [Presentation] The role of Arc in inverse tagging of inactive synapses. (2013)
  • Author(s): Haruhiko Bito
  • Organizer: 25th Winter Conference on Neural Plasticity
  • Place of Presentation: Curacao, Netherlands
  • Invited
• [Presentation] Activity-dependent modulation of receptor dynamics at excitatory synapses. (2013)
  • Author(s): Haruhiko Bito
  • Organizer: 14th International Membrane Research Forum.
  • Place of Presentation: iCEMS, Kyoto
  • Invited
• [Presentation] Nonlinear Decoding and Asymmetric Representation of Neuronal Input Information by CaMKIIα and Calcineurin. (2013)
  • Author(s): Fujii H et al.
  • Organizer: 10th International Conference on Protein Phosphatase
  • Place of Presentation: 国立がんセンター研究所（東京）
  • Invited
• [Presentation] CREB, Arc and Long-Term MemoryFormation (2012)
  • Author(s): Nonaka M, Fukushima H, Sasaki K, Kawashima T, Okuno H, Kida S, Bito H
  • Organizer: 22nd Neuropharmacology Conference 2012
  • Place of Presentation: Hilton Riverside, New Orleans, Louisiana, USA
  • Year and Date: 2012-10-10
• [Presentation] CREB, Arc and long-term memory. (2012)
  • Author(s): Haruhiko Bito
  • Organizer: 7th International Conference on Neurons and Brain Diseases.
  • Place of Presentation: McGill University, Montreal, Canada
  • Invited
• [Presentation] Differential roles for CaM kinases in mediating excitation-morphogenesis coupling during formation and maturation of neuronal circuits. (2012)
  • Author(s): Sayaka Takemoto-Kimura et al.
  • Organizer: International Conference of Physiological Sciences
  • Place of Presentation: Suzhou International Expo Center, Suzhou, China
  • Invited
• [Presentation] Novel functions of Ca2+-dependent phosphorylation cascades in neuritogenesis and emotional behavior. (2012)
  • Author(s): Takemoto-Kimura S et al.
  • Organizer: 第35回神経科学学会大会(Neuro2012)
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Invited
• [Presentation] Nuclear Translocation of CRTC1 Triggers Neuronal Activity- Dependent Gene Ex pression and Enhances Long-Term Memory. (2012)
  • Author(s): Nonaka M et al.
  • Organizer: 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry
  • Place of Presentation: 神戸国際会議場（神戸）
• [Presentation] CREB, Arc and Long-Term Memory Formation (2012)
  • Author(s): Nonaka M et al.
  • Organizer: 22nd Neuropharmacology Conference 2012
  • Place of Presentation: Hilton Riverside, New Orleans, Louisiana, USA
• [Presentation] Non-linear decoding and representation of neuronal input information by CaMKIIα and calcineurin. (2012)
  • Author(s): Fujii H et al.
  • Organizer: 42th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] Visualization of an active ensemble of cortical neurons in vivo using a novel activity-dependent promoter E-SARE. (2012)
  • Author(s): Kawashima T et al.
  • Organizer: 42th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] Resolving dendritic CaMKK-CaMKIV signal transduction during synapse-to-nucleus signaling. (2012)
  • Author(s): Inoue M et al.
  • Organizer: 42th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] Possible involvement of the Ca2+-dependent gene Arc in activity dependent synapse elimination in the cerebellum. (2012)
  • Author(s): Mikuni T et al.
  • Organizer: 42th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] AMPA receptor dynamics quantified using a fluorescence activation-coupled protein labeling (FAPL) method. (2012)
  • Author(s): Ishii Y et al.
  • Organizer: 第35回神経科学学会大会(Neuro2012)
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] Identifying an active ensemble of cortical neurons in vivo using an enhanced synaptic activity-responsive element (E-SARE). (2012)
  • Author(s): Kawashima T et al.
  • Organizer: 第35回神経科学学会大会(Neuro2012)
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] Inverse synaptic tagging: a new mechanism for late-phase synaptic plasticity, (2012)
  • Author(s): Okuno H et al.
  • Organizer: 第35回日本分子生物年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡市）
• [Presentation] dFOMA (dual FRET with Optical MAnipulation)イメージングを用いたCaMKIIαとCalcineurinによる神経入力情報の非線形的デコーディング, (2012)
  • Author(s): Fujii H et al.
  • Organizer: 第35回日本分子生物年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡市）
• [Presentation] Biochemical characterization of Ca2+/calmodulin-dependent protein kinase I gamma as an effective regulator for dendritogenesis in developing cortical neurons. (2012)
  • Author(s): Suzuki K et al
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡市）
• [Presentation] Novel roles of CaMKK-CaMKI cascades in neuritogenesis and circuit formation (2011)
  • Author(s): Takemoto-Kimura S, Horigane S, Adachi-Morishima A, Suzuki K, Kamijo S, Nonaka M, Okuno H, Bito H
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)(招待講演)
  • Year and Date: 2011-12-13
• [Presentation] Real-time imaging of synaptic receptor trafficking using a fluorescence activation-coupled protein labeling (FAPL) method (2011)
  • Author(s): 石井雄一郎, 他
  • Organizer: 第41回北米神経科学学会
  • Place of Presentation: Walter E.Washington Convention Center(ワシントンDC,USA)
  • Year and Date: 2011-11-16
• [Presentation] Increased nuclear shuttling of CRTC1 enhances activity-regulated CREB-dependent gene expression and long-term memory formation (2011)
  • Author(s): 野中美応, 他
  • Organizer: 第41回北米神経科学学会
  • Place of Presentation: Walter E.Washington Convention Center(ワシントンDC,USA)
  • Year and Date: 2011-11-15
• [Presentation] Activity-dependent regulation of dendritogenesis via CLICK-III/CaMKIγ in developing cortical neurons (2011)
  • Author(s): 鈴木敢三, 他
  • Organizer: 第41回北米神経科学学会
  • Place of Presentation: Walter E.Washington Convention Center(ワシントンDC,USA)
  • Year and Date: 2011-11-13
• [Presentation] CaMKK-CaMKIカスケードによる神経細胞形態形成制御と大脳皮質構築 (2011)
  • Author(s): 尾藤晴彦、鈴木敢三、上條諭志、堀金慎一郎、安達-森島亜希、竹本-木村さやか
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 瑠璃光(石川県加賀市)(招待講演)
  • Year and Date: 2011-09-27
• [Presentation] CREB regulation and long-termmemory (2011)
  • Author(s): Bito H
  • Organizer: Joint Meeting of the KoreanSociety for Brain and Neural Science-Asian Molecular and Cellular Cognition Society
  • Place of Presentation: Seoul National University, Seoul, Korea
  • Year and Date: 2011-09-19
• [Presentation] CREB regulation and long-term memory (2011)
  • Author(s): Bito H
  • Organizer: 韓国脳神経学会年会-アジア分子認知学会合同大会
  • Place of Presentation: ソウル国立大学会議場(ソウル市、韓国)(招待講演)
  • Year and Date: 2011-09-19
• [Presentation] 蛍光活性化スイッチを利用したタンパク標識(FAPL)法によるシナプス膜受容体動態の定量的イメージング (2011)
  • Author(s): 石井雄一郎, 他
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-17
• [Presentation] Molecular basis of CLICK-III/CaMKIγ-mediated dendritogenesis in developing cortical neurons (2011)
  • Author(s): 鈴木敢三, 他
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-16
• [Presentation] FRETを用いたCaMKKの基質非依存的酵素学的解析 (2011)
  • Author(s): 井上昌俊, 他
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-16
• [Presentation] Activity-dependent mechanisms underlying neuronal gene expression and neurite growth (2011)
  • Author(s): Bito H
  • Organizer: 第34回日本神経科学学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)(招待講演)
  • Year and Date: 2011-09-15
• [Presentation] Deciphering Ca^<2+> signaling during radial migration of immature cortical neurons (2011)
  • Author(s): 堀金慎一郎, 他
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] シナプスから核へのシグナリングの解読Deciphering the signaling from the synapse to the nucleus (2011)
  • Author(s): 尾藤晴彦, 他
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)(招待講演)
  • Year and Date: 2011-09-15
• [Presentation] Differential usage of the Arc/Arg3.1 gene promoter by the BDNF- and the neuronal activity-induced transcription activation in neurons (2011)
  • Author(s): 津田正明, 他
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] Ca2+シグナル分子による神経入力パターンの特徴抽出と表現 (2011)
  • Author(s): 藤井哉, 他
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] A critical role of CaMKK-CaMKI pathway in neuronal circuit formation (2011)
  • Author(s): S.Horigane, K.Suzuki, S.Takemoto-Kimura, H.Bito
  • Organizer: 6th International Conference on Neurons and Brain Diseases
  • Place of Presentation: ANA Crowne Plaza Hotel(富山市)(招待講演)
  • Year and Date: 2011-08-04
• [Presentation] New roles for CaMK signaling in development and plasticity (2011)
  • Author(s): Bito H
  • Organizer: Gordon Research Conferences "ExcitatorySynapses & Brain Function"
  • Place of Presentation: Stonehill College, Easton, Massachusetts, USA.
  • Year and Date: 2011-06-30
• [Presentation] New roles for CaMK signaling in development and plasticity (2011)
  • Author(s): Bito H
  • Organizer: Gordon Research Conferences "Excitatory Synapses & Brain Function"
  • Place of Presentation: Stonehill College,(Easton,マサチューセッツ州,USA)(招待講演)
  • Year and Date: 2011-06-30
• [Presentation] カルシウム/カルモデュリン依存性蛋白リン酸化酵素Iαとγのサブタイプ特異性と突起伸展制御 (2011)
  • Author(s): 鈴木敢三, 他
  • Organizer: 第26回神経組織の成長・再生・移植研究会学術集会
  • Place of Presentation: 東京医科大学病院(東京都 新宿区)
  • Year and Date: 2011-06-25
• [Presentation] Subtype specificity of Ca^<2+>/calmodulin-dependent protein kinase I α and γ. (2011)
  • Author(s): Suzuki K, Takemoto-Kimura S, Kamijo S, Inoue M, Fujii H, Ageta-Ishihara N, Okuno H, Bito H.
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 誌上開催
  • Year and Date: 2011-03-24
• [Presentation] Regulation of radial migration of cortical pyramidal neurons by a Ca^<2+>/calmodulin-dependent protein kinase I cascade. (2011)
  • Author(s): Horigane S, Takemoto-Kimura S, Adachi-Morishima A, Ageta-Ishihara N, Suzuki K, Nonaka M, Okamura M, Nishimura YV, Kawauchi T, Nakajima K, Okuno H, Bito H
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 誌上開催
  • Year and Date: 2011-03-22
• [Presentation] Dual FRET-based analysis of biochemical computation performed by neuronal Ca2+ signaling (2011)
  • Author(s): Bito H
  • Organizer: The 23^<rd> WinterConference on Neural Plasticity
  • Place of Presentation: Moorea, French Polynesia.
  • Year and Date: 2011-02-15
• [Presentation] Dual FRET-based analysis of biochemical computation performed by neuronal Ca^<2+> signaling. (2011)
  • Author(s): Bito H.
  • Organizer: The 23^<rd> Winter Conference on Neural Plasticity.
  • Place of Presentation: Moorea, French Polynesia.
  • Year and Date: 2011-02-15
• [Presentation] Dual FRET based analysis of biochemical computarion performed by neuronal Ca^<2+> signaling (2011)
  • Author(s): Bito H
  • Organizer: 第23回神経可塑性ウィンターカンファレンス
  • Place of Presentation: Moorea(French Polynesia)
  • Year and Date: 2011-02-15
• [Presentation] Biochemical characterization of Ca^<2+>/calmodulin-dependent protein kinase I subtypes α and γ (2010)
  • Author(s): Suzuki K, Takemoto-Kimura S, Inoue M, Fujii H, Kamijo S, Ageta-Ishihara N, Okuno H, Bito H.
  • Organizer: 第33回分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場・国際展示場(神戸市ポートピア)
  • Year and Date: 2010-12-10
• [Presentation] Enhanced synaptic accumulation of activity-driven Arc protein during sensory deprivation in the mouse visual cortex. (2010)
  • Author(s): Okuno H, Fujii H, Kawashima T, Nonaka M, Yagishita-Kyo N, Ishii Y, Takemoto-Kimura S, Chowdhury S, Worley PF, Bito H
  • Organizer: 第40回北米神経科学学会年会
  • Place of Presentation: San Diego国際会議場(米国サンディエゴ市)
  • Year and Date: 2010-11-17
• [Presentation] Dual FRET-based analysis of biochemical computation performed by neuronal Ca^<2+> signaling processes (2010)
  • Author(s): Fujii H, Inoue M, Okuno H, Takemoto-Kimura S, Bito H
  • Organizer: 第40回北米神経科学学会年会
  • Place of Presentation: San Diego国際会議場(米国サンディエゴ市)
  • Year and Date: 2010-11-16
• [Presentation] Tet-off lentiviral vectors drive high-level transgene expression in marmoset brains. (2010)
  • Author(s): Watakabe A, Takaji M, Nakagami Y, Hioki H, Kaneko T, Kato S, Kobayashi K, Kawashima T, Okuno H, Bito H, Kitamura Y, Yamamori T.
  • Organizer: 第40回北米神経科学学会年会
  • Place of Presentation: San Diego国際会議場(米国サンディエゴ市)
  • Year and Date: 2010-11-16
• [Presentation] Deciphering the role of activity-dependent transcription in long-term memory formation (2010)
  • Author(s): Bito H
  • Organizer: 1^<st> HFSP Alumni Meeting
  • Place of Presentation: 東京大学弥生講堂アネックス
  • Year and Date: 2010-10-09
• [Presentation] Dual FRET-based analysis of biochemical computation performed by neuronal Ca^2+ signaling processes (2010)
  • Author(s): Fujii H, Bito H
  • Organizer: The 2^<nd> International Symposium on Frontiers ofNeurophotonics
  • Place of Presentation: Quebec, Canada
  • Year and Date: 2010-09-22
• [Presentation] Dual FRET-based analysis of biochemical computation performed by neuronal Ca^<2+> signaling processes. (2010)
  • Author(s): Fujii H, Bito H.
  • Organizer: The 2^<nd> International Symposium on Frontiers of Neurophotonics
  • Place of Presentation: Quebec, Canada
  • Year and Date: 2010-09-22
• [Presentation] Dual FRET based analysis of biochemical computation performed by neuronal Ca^<2+> signaling processes (2010)
  • Author(s): Fujii H, Bito H
  • Organizer: 第2回神経フォトニクス先端国際シンポジウム
  • Place of Presentation: Hotel Chateau Laurier (Quebec City, Canada)
  • Year and Date: 2010-09-22
• [Presentation] Synaptic inactivity enhances postsynaptic contents of activity-induced Arcprotein in the neocortex. (2010)
  • Author(s): Okuno H, Kawashima T, Yagishita-Kyo N, Ishii Y, Takemoto-Kimura S, Bito H.
  • Organizer: 第33回日本神経科学学会年会
  • Place of Presentation: 神戸国際会議場・国際展示場(神戸市ポートピア)
  • Year and Date: 2010-09-04
• [Presentation] Histological and behavioral analyses in CL3/CaMKIgamma-deficient mice. (2010)
  • Author(s): Takemoto-Kimura S, Kamijo S, Horigane S, Suzuki K, Okuno H, Haijima A, Endo T, Takeuchi T, Abe M, Natsume R, Yamazaki M, Mori H, Tohyama C, Sakimura K, Mishina M, Kakeyama K, Bito H.
  • Organizer: 第33回日本神経科学学会年会
  • Place of Presentation: 神戸国際会議場・国際展示場(神戸市ポートピア)
  • Year and Date: 2010-09-04
• [Presentation] Behavioral characteristics of CLICKIII/CaMKIgamma knockout male micein social and non-social context. (2010)
  • Author(s): Nakata M, Takemoto-Kimura S, Akashi N, Sakamoto T, Kakeyama M, Yamazaki M, Abe M, Natsume R, Sakimura K, Takeuchi T, Mori H, Mishina M, Bito H, Ogawa S.
  • Organizer: 第33回日本神経科学学会年会
  • Place of Presentation: 神戸国際会議場・国際展示場(神戸市ポートピア)
  • Year and Date: 2010-09-04
• [Presentation] Molecular dissection of the critical role of CRTC 1-CREB in regulating neuronal immediate early gene expression (2010)
  • Author(s): Nonaka M, Kawashima T, Okamura M, Okuno H, Bito H
  • Organizer: 第33回日本神経科学学会年会
  • Place of Presentation: 神戸国際会議場・国際展示場(神戸市ポートピア)
  • Year and Date: 2010-09-03
• [Presentation] Signaling from the synapse to the nucleus and back to the synapse. (2010)
  • Author(s): Bito H, Kawashima T, Inoue M, Yagishita-Kyo N, Nonaka M, Fujii H, Okuno H.
  • Organizer: 第33回日本神経科学学会年会
  • Place of Presentation: 神戸国際会議場・国際展示場(神戸市ポートピア)
  • Year and Date: 2010-09-02
• [Presentation] TET OFF lentiviral vectors drive high-level transgene expression in marmoset brains (2010)
  • Author(s): Watakabe A, Takaji M, Nakagami Y, Hioki H, Kaneko T, Kato S, Kobayashi K, Kawashima T, Okuno H, Bito H, Kitamura Y, Yamamori T
  • Organizer: 第33回日本神経科学学会年会
  • Place of Presentation: 神戸国際会議場・国際展示場(神戸市ポートピア)
  • Year and Date: 2010-09-02
• [Presentation] TET-OFF LENTIVIRAL VECTORS DRIVE HIGH-LEVEL TRANSGENE EXPRESSION IN MARMOSET BRAINS. (2010)
  • Author(s): Watakabe A, Nakagami Y, Takaji M, Hioki H, Kaneko T, Kato S, Kobayashi K, Kawashima T, Okuno H, Bito H, Kitamura Y, Yamamori T.
  • Organizer: 第16回日本遺伝子治療学会年次学術集会
  • Place of Presentation: 栃木県総合文化センター(栃木県宇都宮市)
  • Year and Date: 2010-07-01
• [Presentation] Transcriptional regulation underlying activity-dependent Arc expression (2010)
  • Author(s): Bito H
  • Organizer: 第5回神経細胞・神経疾患国際カンファレンス
  • Place of Presentation: ブリストル大学(英国ブリストル市)
  • Year and Date: 2010-06-29
• [Presentation] 神経回路制御を司る神経活動依存的遺伝子発現と微細形態変化 (2010)
  • Author(s): 尾藤晴彦
  • Organizer: 第37回日本トキシコロジー学会学術年会
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県那覇市)
  • Year and Date: 2010-06-18
• [Presentation] 大脳皮質神経回路形成におけるCaMKK-CaMKIalpha経路の役割 (2010)
  • Author(s): 竹本-木村さやか、上田(石原)奈津実、鈴木敢三、上條諭志、尾藤晴彦
  • Organizer: 神経組織の成長・再生・移植研究会第25回学術集会
  • Place of Presentation: 大阪市立大学阿倍野キャンパス(大阪市)
  • Year and Date: 2010-05-22
• [Presentation] CaM kinase signaling in neuronal microdomains (2010)
  • Author(s): Bito H
  • Organizer: The 13^<th> International Membrane Research Forum/The 6^<th> iCeMS InternationalSymposium Featuring Nano- Meso Membrane Mechanisms
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-01-27
• [Presentation] CaM kinase signaling in neuronal microdomains. (2010)
  • Author(s): Bito H.
  • Organizer: The 13^<th> International Membrane Research Forum/The 6th iCeMS International Symposium Featuring Nano-Meso Membrane Mechanisms.
  • Place of Presentation: Kyoto, Japan.
  • Year and Date: 2010-01-27
• [Presentation] CaM kinase signaling in neuronal microdomains. (2010)
  • Author(s): Bito H
  • Organizer: The 13th International Membrane Research Forum/The 6th iCeMS International Symposium Featuring Nano-Meso Membrane Mechanisms.
  • Place of Presentation: 京都府・ホテルフジタ京都
  • Year and Date: 2010-01-27
• [Presentation] Multiple regulatory elements in the Arc/Arg3.1 promoter essential for synaptic activity-responsive gene expression in activated neurons. (2009)
  • Author(s): 川島尚之
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川県・パシフィコ横浜
  • Year and Date: 2009-12-12
• [Presentation] Activity-dependent regulation of dendritic growth. (2009)
  • Author(s): Takemoto-Kimura S
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 愛知県・名古屋国際会議場
  • Year and Date: 2009-09-16
• [Presentation] A Critical genomic element for synaptic activity-dependent expression of Arc/Are3.1 (2009)
  • Author(s): Okuno H
  • Organizer: 第36回国際生理学会世界大会(IUPS2009)
  • Place of Presentation: 京都府・国立京都国際会館
  • Year and Date: 2009-07-28
• [Presentation] Synaptic activity-dependent regulation of plasticity-related gene Arc (2009)
  • Author(s): Bito H
  • Organizer: 4^<th> International Conference of Neurons and Brain Diseases
  • Place of Presentation: Toronto,Canada
  • Year and Date: 2009-07-23
• [Presentation] Synaptic activity-dependent regulation of plasticity-related gene Arc. (2009)
  • Author(s): Bito H.
  • Organizer: 4^<th> International Conference of Neurons and Brain Diseases
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2009-07-23
• [Presentation] Synaptic Activity-dependent Regulation of Plasticity-related Gene Arc. (2009)
  • Author(s): Bito H
  • Organizer: The 4^<th> International conference of Neurons and Brain Diseases
  • Place of Presentation: トロント・カナダ
  • Year and Date: 2009-07-23
• [Presentation] Differential regulation of cortical dendritic and axonal development via distinct activation of CaMKK-CaMKI pathways, (2008)
  • Author(s): Ageta-Ishihara, N.
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会(BMB2008)
  • Place of Presentation: 神戸神戸国際会議場
  • Year and Date: 2008-12-09
• [Presentation] Distinct regulation of cortical axonal and dendritic development by two Ca2+-CaMKI pathways. (2008)
  • Author(s): Ageta-Ishihara, N
  • Organizer: 第38回北米神経科学学会年会
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-18
• [Presentation] Critical genomic sequences for synaptic activity-dependent expression of the Arc gene. (2008)
  • Author(s): Okuno, H
  • Organizer: 第38回北米神経科学学会年会
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-15
• [Presentation] 異なるCaMKK-CaMKI経路による軸索/樹状突起の特異的形成制御, (2008)
  • Author(s): 上田(石原)奈津実
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山富山国際会議場
  • Year and Date: 2008-09-12
• [Presentation] Regulation of excitation- morphogenesis coupling by CaMKK/CaMKI cascades (2008)
  • Author(s): Bito H
  • Organizer: 3^<rd> International Conference on Neurons and Brain Diseases
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 2008-08-05
• [Presentation] Regulation of excitation-morphogenesis coupling by CaMKK/CaMKI cascades. (2008)
  • Author(s): Bito H.
  • Organizer: 3^<rd> International Conference on Neurons and Brain Diseases.
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 2008-08-05
• [Presentation] Regulation of excitation-morphogenesis coupling by CaMKK/CaMKI cascades. (2008)
  • Author(s): Bito H.
  • Organizer: The 3rd International Conference on Neurons and Brain Diseases.
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-08-05
• [Presentation] Regulation of synaptic localization of Arc protein through interaction with Ca2+/calmodulin-dependent kinase II beta. (2008)
  • Author(s): Okuno, H
  • Organizer: 6th FENS Forum
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2008-07-16
• [Presentation] Dfferential roles of CaMKlgamma; and CaMKIalpha; in cortical dendritic and axonal development (2008)
  • Author(s): Ageta-Ishihara, N.,
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京東京フォーラム
  • Year and Date: 2008-07-09
• [Presentation] New functions for CaM kinases in neurite growth. (2008)
  • Author(s): 尾藤晴彦
  • Organizer: 第60回日本細胞生物学会ミニシンポジウム
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2008-06-29
• [Presentation] Deciphering the signaling from the synapses to the nucleus and from the nucleus back to the synapses.
  • Author(s): Haruhiko Bito
  • Organizer: HHMI Janelia Farm Research Campus Seminar.
  • Place of Presentation: HHMI Janelia Farm Research Campus, Ashburn, Virginia, USA
  • Invited
• [Presentation] New roles of CaM kinases in plasticity and development.
  • Author(s): Haruhiko Bito
  • Organizer: Center for Functional Connectomics Seminar
  • Place of Presentation: Center for Functional Connectomics, Korean Institute for Science and Technology, Seoul, Korea
  • Invited
• [Presentation] The role of Arc in inverse tagging of inactive synapses.
  • Author(s): Haruhiko Bito
  • Organizer: Korea Advanced Institute for Science and Technology Seminar
  • Place of Presentation: Korea Advanced Institute for Science and Technology, Daejeon, Korea
  • Invited
• [Book] 活動依存的な遺伝子発現誘導・ 突起伸展機構.In ブレインサイレンス・レビュー (2013)
  • Author(s): 尾藤晴彦
  • Publisher: 廣川信隆 編、クバプロ
• [Book] 活動依存的な遺伝子発現誘導・突起伸展機構 in ブレインサイエンス・レビュー2013. (2013)
  • Author(s): 尾藤晴彦
  • Publisher: クバプロ
• [Book] "CREB" in "Encyclo-pedia of Signaling Molecules" (2012)
  • Author(s): Yagishita-Kyo N, Inoue M, Nonaka M, Okuno H, Bito H.
  • Publisher: Springer
• [Book] 光技術を用いた神経回路機能の解読と操作 in 実験医学増刊vol . 30 第13号 精神・神経疾患ー発症基盤・病態生理を担う分子カスケードから臨床応用までー (櫻井武，澤明編) (2012)
  • Author(s): 尾藤晴彦
  • Publisher: 羊土社
• [Book] 神経細胞内ではたら くシグナル伝達 in シリーズ脳科学 5 分子・細胞・シナプスからみる脳 甘利 (2008)
  • Author(s): 尾藤晴彦 、有賀 純
  • Publisher: 俊一監修 ,古市貞一 編.東京大学 出版会
• [Book] Activity-dependent gene regulation: Howdo synapses talk to the nucleus and fine-tune neuronal outputs? in "Molecular Pain" (2008)
  • Author(s): Bito H, Takemoto-Kimura S, Okuno H
  • Publisher: M. Zhuo ed. Springer
• [Book] Activity-dependent gene regulation : How do synapses talk to the nucleus and fine-tune neuronal outputs?(in "Molecular Pain"(M.Zhuo ed.)(207-217) (2008)
  • Author(s): Bito H, Takemoto-Kimura S, Okuno H.
  • Publisher: Springer
• [Book] 神経細胞内ではたらくシグナル伝達.In「分子・細胞・シナプスからみる脳」(シリーズ脳科学第5巻、甘利俊一監修、古市貞一編)(131-180) (2008)
  • Author(s): 尾藤晴彦、有賀純
  • Publisher: 東京大学出版会刊
• [Book] シリーズ脳科学第5巻分子・細胞・シナプスからみる脳 (2008)
  • Author(s): 尾藤晴彦
  • Publisher: 東京大学出版会
• [Book] CREB in Encyclopedia of Signaling Molecules (Choi, Sangdun (Ed.))
  • Author(s): Yagishita-Kyo N, Inoue M, Nonaka M, Okuno H, Bito H.
  • Publisher: Springer
• [Remarks]
  • URL: http://www.neurochem.m.u-tokyo.ac.jp/
• [Remarks] 新聞報道 朝日新聞 2009年1月15日 夕刊「記憶のきっかけDNA配列発見」
• [Remarks] ホームページ
  • URL: http://www.neurochem.m.u-tokyo.ac.jp/
• [Patent(Industrial Property Rights)] 神経活動依存的プロモータ活性を有するDNA、及びこれを含むベクター (2012)
  • Inventor(s): 尾藤晴彦、奥野浩行、川島尚之
  • Industrial Property Rights Holder: 尾藤晴彦、奥野浩行、川島尚之
  • Industrial Property Number: 2012-205892
  • Filing Date: 2012-09-19
• [Patent(Industrial Property Rights)] 画像処理装置及びプログラム (2012)
  • Inventor(s): 尾藤晴彦、川島尚之
  • Industrial Property Rights Holder: 尾藤晴彦、川島尚之
  • Industrial Property Number: 2012-170548
  • Filing Date: 2012-07-31
• [Patent(Industrial Property Rights)] CaMKII阻害ペプチドおよびこれを含有するCaMKII阻害剤 (2012)
  • Inventor(s): 西川喜代孝、高橋美帆、西村浩輝、高柳広、尾藤晴彦
  • Industrial Property Rights Holder: 西川喜代孝、高橋美帆、西村浩輝、高柳広、尾藤晴彦
  • Patent Publication Number: 2012-158525
  • Filing Date: 2012-08-23
• [Patent(Industrial Property Rights)] 神経活動依存的プロモータ活性を有するDNA、及びこれを含むベクター (2012)
  • Inventor(s): 尾藤 晴彦、奥野 浩行、川島 尚之
  • Industrial Property Rights Holder: 尾藤 晴彦、奥野 浩行、川島 尚之
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-205892
  • Filing Date: 2012-09-19
• [Patent(Industrial Property Rights)] 画像処理装置及び プログラム (2012)
  • Inventor(s): 尾藤 晴彦、川島 尚之
  • Industrial Property Rights Holder: 尾藤 晴彦、川島 尚之
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-170548
  • Filing Date: 2012-07-31