Multidimensional omics analyses of brain anatomy

• Project/Area Number: 20670004
• Research Category: Grant-in-Aid for Young Scientists (S)
• Allocation Type: Single-year Grants
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SETOU Mitsutoshi 浜松医科大学, 医学部, 教授 (20302664)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥101,530,000 (Direct Cost: ¥78,100,000、Indirect Cost: ¥23,430,000); Fiscal Year 2012: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000); Fiscal Year 2011: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000); Fiscal Year 2010: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000); Fiscal Year 2009: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000); Fiscal Year 2008: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
• Keywords: リピドーム / メタボローム / オミックス / 質量顕微鏡 / リピドミクス / メタボロミクス / ペプチドミクス / 翻訳後修飾 / チュブリン / 脂質 / 代謝物 / オミックス` / 微小管

Research Abstract

Using imaging mass spectrometry we developed, we analyzednervous system in animal models and postmortem human brains. We revealed very unique region-specific or cell type-specific localization of lipids, peptides, and low-molecular metabolites. Furthermore, we offered some candidates for new disease markers by analyzing the human diseased brain. Using animal models, to analyze the time course of brain diseases, we identified spatiotemporal changes of low molecular weight metabolites and lipids. We achieved the multidimensional omics analyses of brain anatomy.

Assessment Rating

Verification Result (Rating)

B

Research Products

• [Journal Article] Sulfatide accumulation in the dystrophic terminals of gracile axonal dystrophy mice : lipid analysis using matrix-assisted laser desorption/ionization imaging mass spectrometry. (2013)
  • Author(s): Onishi S, Tatsumi Y, Wada K, Yang HJ, Sugiura Y, Setou M, Yoshikawa H.
  • Journal Title: Med Mol Morphol.
  • NAID: 10031203183
  • Peer Reviewed
• [Journal Article] Spatiotemporal alteration of phospholipids and prostaglandins in a rat model of spinal cord injury (2012)
  • Author(s): Hanada M, Sugiura Y, Shinjo R, Masaki N, Imagama S, Ishiguro N, Matsuyama Y, Setou M
  • Journal Title: Anal Bioanal Chem Volume: 403巻 Issue: 7 Pages: 1873-1884
  • DOI: 10.1007/s00216-012-5900-3
  • Peer Reviewed
• [Journal Article] Axonal gradient of arachidonic acid-containing phosphatidylcholine and its dependence on actin dynamics (2012)
  • Author(s): Yang H, Sugiura Y, Ikegami K, Konishi Y, Setou M
  • Journal Title: J Biol Chem Volume: 287巻 Issue: 8 Pages: 5290-5300
  • DOI: 10.1074/jbc.m111.316877
  • Peer Reviewed
• [Journal Article] Nanoparticle-assisted Laser Desorption/ionization [nano-PALDI]-based Imaging Mass Spectrometry [IMS] and its Application to Brain Science (2012)
  • Author(s): Hameed S,Sugiura Y, Kimura Y, Shrivas K, Setou M
  • Journal Title: Nanomedicine and the Norvous System Pages: 97-118
  • URL: http://www.crcnetbase.com/doi/abs/10.1201/b11835-8
  • Peer Reviewed
• [Journal Article] SCRAPPER regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal CA3-CAl synapses. (2012)
  • Author(s): Takagi H, Setou M, Ito S, Yao I.
  • Journal Title: Neural Plast. Volume: 2012 Pages: 352829-352829
  • DOI: 10.1155/2012/352829
  • Peer Reviewed
• [Journal Article] Development of imaging mass spectrometry. (2012)
  • Author(s): Saito Y, Waki M, Hameed S, Hayasaka T, Setou M.
  • Journal Title: Biol Pharm Bull. Volume: 35 Pages: 1417-1424
  • NAID: 130001872090
  • Peer Reviewed
• [Journal Article] Visualization of acetylcholine distribution in central nervous system tissue sections by tandem imaging mass spectrometry. (2012)
  • Author(s): Sugiura Y, Zaima N, Setou M, Ito S, Yao I.
  • Journal Title: Anal Bioanal Chem. Volume: 403 Issue: 7 Pages: 1851-1861
  • DOI: 10.1007/s00216-012-5988-5
  • Peer Reviewed
• [Journal Article] Biomedical mass spectrometry. (2012)
  • Author(s): Nakanishi T, Setou M, Kuhara T.
  • Journal Title: Anal Bioanal Chem Volume: 403 Issue: 7 Pages: 1775-1776
  • DOI: 10.1007/s00216-012-5922-x
  • Peer Reviewed
• [Journal Article] Imaging mass spectrometry (2012)
  • Author(s): Setou M.
  • Journal Title: Yakugaku Zasshi Volume: 132 Pages: 499-506
  • NAID: 130001888663
  • Peer Reviewed
• [Journal Article] Nanoparticle-assisted Laser Desorption/ionization [nano-PALDI]-based Imaging Mass Spectrometry [IMS] and its Application to Brain Science (2012)
  • Author(s): Hameed S, Sugiura Y, Kimura Y, Shrivas K, Setou M
  • Journal Title: Nanomedicine and the Norvous System Pages: 97-118
  • Peer Reviewed
• [Journal Article] Abnormal phospholipids distribution in theprefrontal cortex from a patient withschizophrenia revealed by matrix-assisted laser desorption/ionization imaging mass spectrometry (2011)
  • Author(s): Matsumoto J, Sugiura Y, Yuki D, Hayasaka T, Goto-Inoue N,Zaima N, Kunii Y, Wada A, Yang Q, Nishiura K, Akatsu H, Hori A, Hashizume Y, Yamamoto T, Ikemoto K, Setou M, Niwa SI
  • Journal Title: Anal Bioanal Chem Volume: 400巻 Issue: 7 Pages: 1933-43
  • DOI: 10.1007/s00216-011-4909-3
  • Peer Reviewed
• [Journal Article] Visualization of neuropeptides in paraffin-embedded tissue sections of the central nervous system in the decapod crustacean, Penaeus monodon, by imaging mass spectrometry (2011)
  • Author(s): Chansela P, Goto-Inoue N, Zaima N,Sroyraya M, Sobhon P, Setou M
  • Journal Title: Peptides Volume: 34巻 Issue: 1 Pages: 10-18
  • DOI: 10.1016/j.peptides.2011.03.021
  • Peer Reviewed
• [Journal Article] Imaging Mass Spectrometry Evaluation of the Effects of Various Irrigation Fluids in a Rat Model of Postoperative Cerebral Edema. (2011)
  • Author(s): Koizumi S, Hayasaka T, Goto-Inoue N, Doi K, Setou M, Namba H
  • Journal Title: World Neurosurq Volume: 77巻 Issue: 1 Pages: 153-159
  • DOI: 10.1016/j.wneu.2011.03.039
  • Peer Reviewed
• [Journal Article] Hydroxylated and non-hydroxylated sulfatide are distinctly distributed in the human cerebral cortex (2011)
  • Author(s): Yuki D, Sugiura Y, Zaima N, Akatsu H, Hashizume Y, Yamamoto T, Fujiwara M, Sugiyama K, Setou M
  • Journal Title: Neuroscience Volume: 193巻 Pages: 44-53
  • DOI: 10.1016/j.neuroscience.2011.07.045
  • Peer Reviewed
• [Journal Article] Method for Simultaneous Imaging of Endogenous Low Molecular Weight Metabolites in Mouse Brain Using TiO(2) Nanoparticle in Nanoparticle-Assisted Laser Desorption/Ionization-Imaging Mass Spectrometry (2011)
  • Author(s): Shrivas K, Hayasaka T, Sugiura Y, Setou M
  • Journal Title: Anal Chem Volume: 83巻 Issue: 19 Pages: 7283-7289
  • DOI: 10.1021/ac201602s
  • Peer Reviewed
• [Journal Article] Imaging Technology of Complex Lipid Molecular Species by a Combination of TLC-Blot and MALDI-TOF ?Special Reference to Human Brain Ganglioside Molecular Species (2011)
  • Author(s): Valdes-Gonzalez T, Goto-Inoue N, Hayasaka T, Ishiyama H, Setou M, Taki T
  • Journal Title: J Glycom Lipidom Volume: 1巻 Issue: 01 Pages: 1000104-1000104
  • DOI: 10.4172/2153-0637.1000104
  • Peer Reviewed
• [Journal Article] Visualization of Spatiotemporal Energy Dynamics of Hippocampal Neurons by Mass Spectrometry during a Kainate-Induced Seizure (2011)
  • Author(s): Sugiura Y, Taguchi R, Setou M
  • Journal Title: PLoS One Volume: 6巻 Pages: 17952-17952
  • URL: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017952
  • Peer Reviewed
• [Journal Article] Insufficient remodeling of membranes of mitochondria and axon terminals causes neuroaxonal dystrophy in calcium-independent phospholipase A2b deficiency. (2011)
  • Author(s): Beck, G.
  • Journal Title: Journal of Neuroscience Volume: VOL. 31 Issue: 31 Pages: 11411-11420
  • DOI: 10.1523/jneurosci.0345-11.2011
  • Peer Reviewed
• [Journal Article] Imaging mass spectrometry for lipidomics (2011)
  • Author(s): Goto-Inoue N, Hayasaka T, Zaima N, Setou M
  • Journal Title: Biochim Biophys Acta. Volume: 1811 Issue: 11 Pages: 961-969
  • DOI: 10.1016/j.bbalip.2011.03.004
  • Peer Reviewed
• [Journal Article] Visualization of Spatiotemporal Energy Dynamics of Hippocampal Neurons by Mass Spectrometry during a Kainate-Induced Seizure. (2011)
  • Author(s): Sugiura Y, Taguchi R, Setou M.
  • Journal Title: PLoS One. Volume: 6
  • Peer Reviewed
• [Journal Article] Synaptic E3 Ligase SCRAPPER in Contextual Fear Conditioning : Extensive Behavioral Phenotyping of Scrapper Heterozygote and Overexpressing Mutant Mice. (2011)
  • Author(s): Yao I, Takao K, Miyakawa T, Ito S, Setou M.
  • Journal Title: PLoS One. Volume: 6
  • Peer Reviewed
• [Journal Article] Selective analysis of lipids by thin-layer chromatography blot matrix-assisted laser desorption/ionization imaging mass spectrometry. (2011)
  • Author(s): Zaima N, Goto-Inoue N, Setou M.
  • Journal Title: J Oleo Sci. Volume: 60 Pages: 93-98
  • NAID: 130000438332
  • Peer Reviewed
• [Journal Article] Ionic matrix for enhanced MALDI imaging mass spectrometry for identification of phospholipids in mouse liver and cerebellum tissue sections (2010)
  • Author(s): Shrivas K, Hayasaka T, Goto-Inoue N, Zaima N, Setou M
  • Journal Title: Anal Chem Volume: 82巻 Pages: 8800-8806
  • URL: http://pubs.acs.org/doi/abs/10.1021/ac102422b
  • Peer Reviewed
• [Journal Article] Detection of characteristic distributions of phospholipid head groups and fatty acids on neurite surface by time of flight-secondary ion mass spectrometry (2010)
  • Author(s): Yang HJ, Ishizaki I, Sanada N, Zaima N, Sugiura Y, Yao I, Ikegami K, Setou M
  • Journal Title: Med Mol Morphol Volume: 43巻 Pages: 158-164
  • NAID: 10026727212
  • URL: http://link.springer.com/article/10.1007%2Fs00795-009-0487-2
  • Peer Reviewed
• [Journal Article] Imaging mass spectrometry revealed the production of lyso-phosphatidylcholine in the injured ischemic rat brain (2010)
  • Author(s): Koizumi S, Yamamoto S, Hayasaka T, Konishi Y, Yamaguchi-Okada M, Goto-Inoue N, Sugiura Y, Setou M, Namba H
  • Journal Title: Neuroscience Volume: 168巻 Pages: 219-225
  • URL: http://www.sciencedirect.com/science/article/pii/S0306452210004513
  • Peer Reviewed
• [Journal Article] The detection of glycosphingolipids in brain tissue sections by imaging mass spectrometry using gold nanoparticles (2010)
  • Author(s): Goto-Inoue N, Hayasaka T, Zaima N, Kashiwagi Y, Yamamoto M, Nakamoto M, Setou M
  • Journal Title: J Am Soc Mass Spectrom Volume: 21巻 Pages: 1940-1943
  • URL: http://link.springer.com/article/10.1016%2Fj.jasms.2010.08.002
  • Peer Reviewed
• [Journal Article] Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs) (2010)
  • Author(s): Kimura Y, Kurabe N, Ikegami K, Tsutsumi K, Konishi Y, Kaplan OI, Kunitomo H, Iino Y, Blacque OE, Setou M.
  • Journal Title: J Biol Chem 285(30) Pages: 22936-22941
  • Peer Reviewed
• [Journal Article] Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry. (2010)
  • Author(s): Ikegami K, Sato S, Nakamura K, Ostrowski LE, Setou M.
  • Journal Title: Proc Natl Acad Sci USA 107 Pages: 10490-10495
  • Peer Reviewed
• [Journal Article] Specific localization of five phosphatidylcholine species in the cochlea by using mass microscopy. (2010)
  • Author(s): Takizawa Y, Mizuta K, Hayasaka T, Nakanishi H, Okamura J, Mineta H, Setou M.
  • Journal Title: Audiol Neurootol. Volume: 16 Pages: 315-322
  • Peer Reviewed
• [Journal Article] Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry. (2010)
  • Author(s): Zaima N, Hayasaka T, Goto-Inoue N, Setou M.
  • Journal Title: Int J Mol Sci. Volume: 11 Pages: 5040-5055
  • Peer Reviewed
• [Journal Article] AP-1 clathrin adaptor facilitates cilium formation and functions with RAB-8 in C. elegans neuronal ciliary membrane transport. (2010)
  • Author(s): Kaplan O, Herman AM, Cevik S, Ghossoub R, Kida K, Kimura Y, Jenkins P, Martens J, Setou M, Benmerah A, Blacque OE.
  • Journal Title: J Cell Sci. Volume: 123 Pages: 3966-3977
  • Peer Reviewed
• [Journal Article] Ionic matrix for enhanced MALDI imaging mass spectrometry for identification of phospholipids in mouse liver and cerebellum tissue sections. (2010)
  • Author(s): Shrivas K, Hayasaka T, Goto-Inoue N, Zaima N, Setou M.
  • Journal Title: Anal Chem. Volume: 82 Pages: 8800-8806
  • Peer Reviewed
• [Journal Article] Detection of characteristic distributions of phospholipid head groups and fatty acids on neurite surface by time of flight-secondary ion mass spectrometry. (2010)
  • Author(s): Yang HJ, Ishizaki I, Sanada N, Zaima N, Sugiura Y, Yao I, Ikegami K, Setou M.
  • Journal Title: Med Mol Morphol. Volume: 43 Pages: 158-164
  • NAID: 10026727212
  • Peer Reviewed
• [Journal Article] Identification of Tubulin Deglutamylase among Caenorhabditis elegans and Mammalian Cytosolic Carboxypeptidases (CCPs). (2010)
  • Author(s): Kimura Y, Kurabe N, Ikegami K, Tsutsumi K, Konishi Y, Kaplan OI, Kunitomo H, Iino Y, Blacque OE, Setou M.
  • Journal Title: J Biol Chem. Volume: 285 Pages: 22936-22941
  • Peer Reviewed
• [Journal Article] SIRT1 regulates TSH release by enhancing PIP5Ky activity through deacetylation. (2010)
  • Author(s): Asai-Akieda S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song SY, Matsuno A, Mizutani A, Sawabe M, Chao MV, Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M.
  • Journal Title: PloS One. Volume: 5
  • Peer Reviewed
• [Journal Article] Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry. (2010)
  • Author(s): Ikegami K, Sato S, Nakamura K, Ostrowski LE, Setou M.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 107 Pages: 10490-10495
  • Peer Reviewed
• [Journal Article] Imaging mass spectrometry revealed the production of lyso-phosphatidyl choline in the injured ischemic rat brain. (2010)
  • Author(s): Koizumi S, Yamamoto S, Hayasaka T, Konishi Y, Yamaguchi-Okada M, Goto-Inoue N, Sugiura Y, Setou M, Namba H.
  • Journal Title: Neuroscience. Volume: 168 Pages: 219-225
  • Peer Reviewed
• [Journal Article] Fbxo45, a novel ubiquitin ligase, regulates synaptic activity. (2010)
  • Author(s): Tada H, Okano HJ, Takagi H, Shibata S, Matsumoto M, Yao I, Saiga T, Nakayama KI, Kashima H, Takahashi T, Setou M, Okano H.
  • Journal Title: J Biol Chem. Volume: 285 Pages: 3840-3849
  • Peer Reviewed
• [Journal Article] Detection of characteristic distributions of phospholipid head groups and fatty acids on neurite surface by time of flight-secondary ion mass spe ctrometry. (2010)
  • Author(s): Yang HJ, Ishizaki I, Sanada N, Zaima N, Sugiura Y, Yao I, Ikegami K, Setou M.
  • Journal Title: Med Mol Morphol. Volume: 43 Pages: 158-164
  • NAID: 10026727212
  • Peer Reviewed
• [Journal Article] he detection of glycosphingolipids in brain tissue sections by imaging mass spectrometry using gold nanoparticles. (2010)
  • Author(s): Goto-Inoue N, Hayasaka T, Zaima N, Kashiwagi Y, Yamamoto M, Nakamoto M, Setou M.
  • Journal Title: J Am Soc Mass Spectrom. Volume: 21 Pages: 1940-1943
  • Peer Reviewed
• [Journal Article] Developments and applications of mass microscopy (2010)
  • Author(s): Setou M, Shrivas K, Sroyraya M, Yang H, Sugiura Y, Moribe J, Kondo A, Tsutsumi K, Kimura Y, Kurabe N, Hayasaka T, Goto-Inoue N, Zaima N, Ikegami K, Sobhon P, Konishi Y.
  • Journal Title: Med Mol Morphol 43 Pages: 1-5
  • NAID: 10026443006
  • Peer Reviewed
• [Journal Article] 質量顕微鏡の医学への応用 (2010)
  • Author(s): 森部絢嗣, 瀬藤光利
  • Journal Title: 医学のあゆみ 232 Pages: 817-818
• [Journal Article] 質量顕微鏡で生命の謎を解く (2010)
  • Author(s): 大畑健次, 小西慶幸, 瀬藤光利
  • Journal Title: 生物物理 50 Pages: 80-83
  • NAID: 10025976259
  • Peer Reviewed
• [Journal Article] 質量顕微鏡法 (2010)
  • Author(s): 尾上健児, 斎藤能彦, 瀬藤光利
  • Journal Title: 細胞 42 Pages: 23-26
  • NAID: 130001888663
• [Journal Article] Unique Post-translational Modifications in Specialized Microtubule Architecture (2010)
  • Author(s): Ikegami K, Setou M
  • Journal Title: Cell Structure and Function 35 Pages: 15-22
  • NAID: 130004137553
  • Peer Reviewed
• [Journal Article] 質量顕微鏡による解析 (2010)
  • Author(s): 倉部誠也, 杉浦悠毅, 瀬藤光利
  • Journal Title: 実験医学 28 Pages: 21-26
• [Journal Article] 時間的・空間的な生命現象理解のための最新テクノロジー (2010)
  • Author(s): 瀬藤光利
  • Journal Title: 実験医学 28 Pages: 2-6
• [Journal Article] メタボロームの分布可視化法について (2010)
  • Author(s): 中村貴, 早坂孝宏, 井上菜穂子, 仁科博史, 瀬藤光利
  • Journal Title: 遺伝子医学MOOK 16 Pages: 131-135
• [Journal Article] Imaging mass spectrometry for visualization of drug and endogenous metabolite distribution : toward in situ pharmacometabolomes (2010)
  • Author(s): 杉浦悠毅, 瀬藤光利
  • Journal Title: Journal of Neuroimmune Pharmacology 5 Pages: 31-43
  • Peer Reviewed
• [Journal Article] Organ-specific distributions of lysophosphatidylcholine and triacylglycerol in mouse embryo (2009)
  • Author(s): Hayasaka T, Goto-Inoue N, Zaima N, Kimura Y and Setou M
  • Journal Title: Lipids Volume: 44巻 Pages: 837-848
  • URL: http://link.springer.com/article/10.1007%2Fs11745-009-3331-5
  • Peer Reviewed
• [Journal Article] Visualization of the cell-selective distribution of PUFA-containingphosphatidylcholines in mouse brain by imaging mass spectrometry (2009)
  • Author(s): Sugiura Y, Konishi Y, Zaima N, Kajihara S, Nakanishi H, Taguchi R, Setou M
  • Journal Title: Journal of Lipid Research Volume: 50巻 Pages: 1776-1788
  • URL: http://www.jlr.org/content/50/9/1776.full.pdf
  • Peer Reviewed
• [Journal Article] Layer-specific sulfatide localization in rat hippocampus middle molecular layer is revealed by nanoparticle-assisted laser desorption/ionization imaging mass spectrometr (2009)
  • Author(s): Ageta H, Asai S, Sugiura Y, Goto-Inoue N, Zaima N, Setou M
  • Journal Title: Medical Molecular Morphology Volume: 42巻 Pages: 16-23
  • URL: http://link.springer.com/article/10.1007%2Fs00795-008-0427-6
  • Peer Reviewed
• [Journal Article] Tubulin tyrosination navigates the kinesin-1 motor domain to axons (2009)
  • Author(s): Konishi Y, Setou M
  • Journal Title: Nat Neurosci Volume: 12巻 Pages: 559-567
  • URL: http://www.nature.com/neuro/journal/v12/n5/pdf/nn.2314.pdf
  • Peer Reviewed
• [Journal Article] Tubulin tyrosination navigates the kinesin-1 motor domain to axons. (2009)
  • Author(s): Konishi Y, Setou M.
  • Journal Title: Nat Neurosci 12
  • Peer Reviewed
• [Journal Article] Organ-specific distributions of lysophosphatidylcholine and triacylglycerol in mouse embryo (2009)
  • Author(s): Hayasaka T, Goto-Inoue N, Zaima N, Kimura Y, Setou M.
  • Journal Title: Lipids 44 Pages: 837-848
  • Peer Reviewed
• [Journal Article] Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry (2009)
  • Author(s): Sugiura Y, Konishi Y, Zaima N, Kajihara S, Nakanishi H, Taguchi R, Setou M.
  • Journal Title: Journal of Lipid Research 50 Pages: 1776-1788
  • Peer Reviewed
• [Journal Article] TTLL10 can perform tubulin glycylation when co-expressed with TTLL8 (2009)
  • Author(s): Ikegami K, Setou M
  • Journal Title: FEBS Letters 583 Pages: 1957-1963
  • Peer Reviewed
• [Journal Article] Tubulin tyrosination navigates the kinesin-1 motor domain to axons (2009)
  • Author(s): 小西慶幸, 瀬藤光利
  • Journal Title: Nature Neuroscience 12 Pages: 559-567
  • Peer Reviewed
• [Journal Article] Visualizing the spatial distribution of biomolecules in C. elegans by imaping mass Spectrometry (2009)
  • Author(s): Kimura, Y, Sugiura, Y, Hayasaka, T, Setou, M.
  • Journal Title: Worm Breeder's Gazette 18 Pages: 4-4
  • Peer Reviewed
• [Journal Article] 質量分板イメージング法 : 質量顕微鏡法について (2009)
  • Author(s): 瀧澤義徳, 田中宏樹, 早坂孝宏, 瀬藤光利
  • Journal Title: 細胞工学 別冊 Pages: 51-60
• [Journal Article] Imaging mass spectrometry : principle and application Biophysical Reviews (2009)
  • Author(s): Murayama C, Kimura Y, Setou M.
  • Journal Title: Biophys Rev 1 Pages: 131-139
  • Peer Reviewed
• [Journal Article] 質量顕微鏡法 (2009)
  • Author(s): 早坂孝宏, 杉浦悠毅, 瀬藤光利
  • Journal Title: 組織細胞化学2009 Pages: 159-166
  • NAID: 130001888663
• [Journal Article] Medical molecular morphology with imaging mass spectrometry (2009)
  • Author(s): Kimura Y, Tsutsumi K, Sugiura Y, Setou M.
  • Journal Title: Medical molecular morphology 42 Pages: 133-137
  • NAID: 10025860101
  • Peer Reviewed
• [Journal Article] ガングリオシド研究における質量顕微鏡法の応用 (2009)
  • Author(s): 井上菜穂子, 瀬藤光利
  • Journal Title: 生体の科学 60 Pages: 240-247
• [Journal Article] ジョジョに奇妙な脳科学 (2009)
  • Author(s): 瀬藤光利
  • Journal Title: 解き明かされる脳の不思議 脳科学の未来 Pages: 55-72
• [Journal Article] Current imaging mass spectrometry for metabolite molecules (2009)
  • Author(s): 杉浦悠毅, 瀬藤光利
  • Journal Title: Journal of the Mass Spectrometry Society of Japan 57 Pages: 133-143
  • NAID: 10024837528
  • Peer Reviewed
• [Journal Article] 質量顕微鏡法の原理と応用 (2009)
  • Author(s): 田中宏樹, 森田剛文, 杉浦悠毅, 瀬藤光利
  • Journal Title: 蛋白質 核酸 酵素 54 Pages: 224-229
• [Journal Article] 革命的なイメージング装置・質量顕微鏡 (2009)
  • Author(s): 瀬藤光利
  • Journal Title: 化学と教育誌 57 Pages: 86-87
• [Journal Article] Chapter 8. Role of synapse-localized E3 ubiquitin ligase in regulating neural transmission : Di Napoli M, and Wojcik C. Eds : The ubiquitin proteasome system in nervous system : from physiology to pathology-2008 update (2009)
  • Author(s): Yao I, Ageta H, Setou M
  • Journal Title: Biochemistry Research Trends Binding Pages: 131-150
• [Journal Article] Layer-specific sulfatide localization in rat hippocampus middle molecular layer is revealed by nanoparticle-assisted laser desorption/ionization imaging mass speotrometr (2009)
  • Author(s): Ageta H, Asai S, Sugiura Y, Goto-Inoue N, Zaima N, Setou M
  • Journal Title: Medical Molecular Morphology 42 Pages: 16-23
  • Peer Reviewed
• [Journal Article] Imaging Mass Spectrometry technology and the application on ganglioside study; Visualization of Age-dependent Accumulation of C20-Ganglioside Molecular Species in the Mouse Hippocampus (2008)
  • Author(s): Sugiura Y, Shimma S, Konishi Y, Yamada M, Setou M
  • Journal Title: PLoS ONE Volume: 3巻 Pages: 3232-3232
  • NAID: 120004026127
  • URL: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003232
  • Peer Reviewed
• [Journal Article] Imaging mass spectrometry technology and application on ganglioside study; visualization of age-dependent accumulation of C20-ganglioside molecular species in the mouse hippocampus. (2008)
  • Author(s): Sugiura Y, Shimma S, Konishi Y, Yamada MK, Setou M.
  • Journal Title: PLoS One 3(9)
  • NAID: 120004026127
  • Peer Reviewed
• [Journal Article] novel chalcine polyphenol inhibits the deacetylase activity of SIRTl and cell growth in HEK293T cells (2008)
  • Author(s): Kahyo T, Ichikawa S, Hatanaka T, Yainada M, Setou M
  • Journal Title: Journal of Pharmacological Sciences 108 Pages: 364-371
  • Peer Reviewed
• [Journal Article] Imaging Mass Spectrometry technology and the application on ganglioside study ; Visualization of Age-dependent Accumulation of C20-Ganglioside M-olecular Species in the Mouse Hippocampus. (2008)
  • Author(s): Sugiura Y, Shimma S, Konishi Y, Yamada M, Setou M
  • Journal Title: PLoS ONE 3
  • NAID: 120004026127
  • Peer Reviewed
• [Journal Article] Enhancement of Trk signaling pathways by a cholestane amide conjugate, MCC-257 (2008)
  • Author(s): Yamada M, Konishi Y, Kakinoki B, Ikegami K, Setou M
  • Journal Title: J. Pharmacol. Sci. 108 Pages: 131-134
  • NAID: 10024322692
  • Peer Reviewed
• [Journal Article] Transmembrane and Ubiquitin-like Domain-containing Proteinl (Tmubl/HOPS) Facilitates Surface Expression of GluR2-containing AMPA Receptors (2008)
  • Author(s): Yang H, Takagi H, Konishi Y, Ageta H, Ikegami K, Yao I, Satou S, Hatanaka K, Inokuchi K, Seog D-H, Setou M
  • Journal Title: PLoS ONE 3
  • Peer Reviewed
• [Journal Article] Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein (2008)
  • Author(s): Kahyo T, Mostoslavsky R, Goto M, Setou M
  • Journal Title: FEES Letters 582 Pages: 2479-2483
  • Peer Reviewed
• [Journal Article] Spectrum Normalization Method Using an External Standard in Mass Spectrometric Imaging (2008)
  • Author(s): Hosokawa N, Sugiura Y, Setou M
  • Journal Title: J. Mass Spectrom. Soc. Jpn 56 Pages: 77-81
  • NAID: 10021086558
  • Peer Reviewed
• [Journal Article] TILL 10 is a protein polyglylase that can modify mucleosome assembly protein 1 (2008)
  • Author(s): Ikegami K, Horigome D, Mukai M, Livnat I, MacGregor GR, Setou M
  • Journal Title: FEBS Letters 582 Pages: 1129-1134
  • Peer Reviewed
• [Journal Article] Ionic Matrix for Enhanced MALDI Imaging Mass Spectrometry for Identification of Phospholipids in Mouse Liver and Cerebellum Tissue Sections.
  • Author(s): Shrivas K, Hayasaka T, Goto-Inoue N, Sugiura Y, Zaima N, Setou M.
  • Journal Title: Anal Chem. in press
  • Peer Reviewed
• [Presentation] 質量顕微鏡法による生体機能の解明と応用について (2013)
  • Author(s): 瀬藤光利
  • Organizer: 生体機能の解明とその応用に関する研究会
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2013-03-11
• [Presentation] Novel analytical approches by new high space resolutional imaging mass spectrometry (2013)
  • Author(s): 瀬藤光利
  • Organizer: Mass Spectrometry 2013
  • Place of Presentation: シンガポール(招待講演)
  • Year and Date: 2013-03-07
• [Presentation] 質量顕微鏡法について(質量分析イメージング) (2013)
  • Author(s): 瀬藤光利
  • Organizer: 第37回分析機器展
  • Place of Presentation: 大阪(特別講演)
  • Year and Date: 2013-02-21
• [Presentation] Distribution of lipids analyzed by imaging mass spectrometry (2013)
  • Author(s): 瀬藤光利
  • Organizer: Seminar at MPI-CBG
  • Place of Presentation: ドレスデン(特別講演)
  • Year and Date: 2013-01-11
• [Presentation] Development and application of imaging mass spectrometry (2013)
  • Author(s): 瀬藤光利
  • Organizer: 超領域日中韓国際シンポジウム
  • Place of Presentation: 静岡(招待講演)
  • Year and Date: 2013-01-07
• [Presentation] The Role of Tubulin Polyglutamylation on The Regulation of Neuronal Cytoskeleton (2012)
  • Author(s): K.Ohata, Y.Konishi, R.Tsuchiya, K.Ikegami, M.Setou
  • Organizer: The 51st ASCB
  • Place of Presentation: Denver(アメリカ)(ポスター発表)
  • Year and Date: 2012-12-04
• [Presentation] 脂質を「見る」質量顕微鏡の進歩 (2012)
  • Author(s): 瀬藤光利
  • Organizer: 千里ライフサイエンスセミナー
  • Place of Presentation: 豊中市(招待講演)
  • Year and Date: 2012-11-15
• [Presentation] イメージング質量分析の最近の進展 (2012)
  • Author(s): 瀬藤光利
  • Organizer: 第7回北海道大学大学院医学研究科連携研究センターシンポジウム
  • Place of Presentation: 北海道(特別講演)
  • Year and Date: 2012-11-09
• [Presentation] -過性全脳虚血後の海馬神経細胞死の分子imaging-質量顕微鏡法を用いた分子動態解析- (2012)
  • Author(s): 宮脇哲、早坂孝宏、今井英明、小野秀明、堀川弘吏、越智崇、伊藤明博、中富浩文、瀬藤光利、斉藤延人
  • Organizer: 第13回日本分子脳神経外科学会
  • Place of Presentation: 熊本(一般講演)
  • Year and Date: 2012-09-21
• [Presentation] Optimization of conditions for acetylcholine detection in the nerve tissuesections by imaging mass spectrometry (2012)
  • Author(s): Ikuko Yao, Yuki Sugiura, Nobuhiro Zaima, Mistutoshi Setou, Seiji Ito
  • Organizer: IMSC2012 19th International Mass Spectrometry Conference
  • Place of Presentation: 京都(ポスター発表)
  • Year and Date: 2012-09-17
• [Presentation] Introduction to Imaging Mass Spectrometry (2012)
  • Author(s): 瀬藤光利、矢尾育子、早坂孝宏、正木紀隆、Cecilia Eriksson
  • Organizer: IMSC2012 19th International Mass Spectrometry Conference ショートコース(ワークショップ演者)
  • Place of Presentation: 京都
  • Year and Date: 2012-09-15
• [Presentation] the 14th International Congress of Histochemistry and Cytochemistry (ICHC 2012) (2012)
  • Author(s): 瀬藤光利
  • Organizer: the 14th International Congress of Histochemistry and Cytochemistry (ICHC 2012)
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2012-08-28
• [Presentation] 質量顕微鏡 質量分析を利用したバイオイメージング (2012)
  • Author(s): 瀬藤光利, 矢尾育子
  • Organizer: 第21回 日本バイオイメージング学会学術集会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2012-08-27
• [Presentation] 質量分析イメージング法の開発と応用 (2012)
  • Author(s): 瀬藤光利
  • Organizer: 静岡県立大学院薬学研究院月例セミナー
  • Place of Presentation: 静岡(招待講演)
  • Year and Date: 2012-07-09
• [Presentation] 質量顕微鏡法の研究開発 (2012)
  • Author(s): 瀬藤光利
  • Organizer: 東京大学グローバルCOE・CMSI「ナノバイオ工学」
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2012-07-05
• [Presentation] Cell Imaging and signaling research using mass spectrometry (2012)
  • Author(s): 瀬藤光利
  • Organizer: The 34th conference of the Korean Society of Cell Biology
  • Place of Presentation: ウルサン(招待講演)
  • Year and Date: 2012-06-22
• [Presentation] 質量顕微鏡を用いた解析例と今後の展開 (2012)
  • Author(s): 瀬藤光利
  • Organizer: 島津サイエンス西日本(株) 主催 講演
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2012-06-15
• [Presentation] 生体サンプルの MALDI イメージング質量分析に関する研究 (2012)
  • Author(s): 瀬藤光利
  • Organizer: 日本質量分析学会総会 日本質量分析学会奨励賞受賞講演(特別講演)
  • Place of Presentation: 東京
  • Year and Date: 2012-06-01
• [Presentation] 生体サンプルのMALDIイメージング質量分析に関する研究 (2012)
  • Author(s): 瀬藤光利
  • Organizer: 日本質量分析学会総会 日本質量分析学会奨励賞受賞講演
  • Place of Presentation: 東京(特別講演)
  • Year and Date: 2012-06-01
• [Presentation] Intraflagellar transport is modulated by environmental stimuli through tubulin polyglutamylation (2012)
  • Author(s): Yoshishige Kimura, Saira Hameed, Koji Tsutsumi, Mitsutoshi Setou
  • Organizer: Joint meeting of The 45th Annual Meeting of the Japanaese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for CeU Biology
  • Place of Presentation: 神戸(ポスター発表)
  • Year and Date: 2012-05-30
• [Presentation] グルタミン酸化修飾の機能 (2012)
  • Author(s): 瀬藤光利、池上浩司
  • Organizer: 日本生化学会中部支部例会・シンポジウム(シンポジスト)
  • Place of Presentation: 岡崎
  • Year and Date: 2012-05-26
• [Presentation] 質量顕微鏡法を用いたラット遅発性神経細胞死における分子動態解析 (2012)
  • Author(s): 宮脇哲、早坂孝宏、小野秀明、今井英明、堀川弘吏、越智崇、伊藤明博、中富浩文、瀬藤光利、斉藤延人
  • Organizer: 第37回日本脳卒中学会(シンポジスト)
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-27
• [Presentation] 質量顕微鏡によるバイオイメージング:現状と将来展望 (2012)
  • Author(s): 瀬藤光利
  • Organizer: ナノプローブテクノロジー第167委員会 第66回研究会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2012-04-19
• [Presentation] Tubulin polyglutamylation regulates cytoskeletal distribution in brain (2012)
  • Author(s): Ohata K, Konishi Y, Tsuchiya R, Ikegami K, Setou M
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学(甲府)(ポスター発表)
  • Year and Date: 2012-03-28
• [Presentation] Biochemical Mapping with MALDI Imaging Mass Spectrometry (2012)
  • Author(s): Mitsutoshi Setou
  • Organizer: 2012春季第59回応用物理学関係連合講演会
  • Place of Presentation: 早稲田大学(東京)(招待講演)
  • Year and Date: 2012-03-15
• [Presentation] Axonal distribution of lipids revealed by imaging mass spectrometry (2012)
  • Author(s): Mitsutoshi Setou
  • Organizer: 第42回生理研国際シンポジウム生理研・新潟脳研合同シンポジウム
  • Place of Presentation: 生理学研究所(岡崎)(招待講演)
  • Year and Date: 2012-03-07
• [Presentation] 質量分析イメージングデータの定量生物学的解析法 (2012)
  • Author(s): 瀬藤光利
  • Organizer: 第35回 日本分子生物学会年会(ワークショップ演者)
  • Place of Presentation: 福岡
• [Presentation] Anatomy With Imaging Mass Spectrometry (2012)
  • Author(s): 瀬藤光利
  • Organizer: the 2nd International Anatomical Sciences and Cell Biology Conference (シンポジスト)
  • Place of Presentation: タイ
• [Presentation] Cell Biology of Aging Process (2012)
  • Author(s): 瀬藤光利
  • Organizer: the 2nd International Anatomical Sciences and Cell Biology Conference(特別講演)
  • Place of Presentation: タイ(特別講演)
• [Presentation] Imaging mass spectrometry provides the comprehensive analysis of the dynamic change of phospholipids in selective white matter injury of the rat model (2012)
  • Author(s): 小野秀明, 今井英明, 早坂孝宏, 宮脇哲, 堀川弘吏, 越智崇, 伊藤明博, 瀬藤光利, 齊藤延人
  • Organizer: Neuroscience 2012 SFN's 42nd annual meeting
  • Place of Presentation: ニューオリンズ(ポスター発表)
• [Presentation] Molecular imaging of rat hippocampus after transit global ischemia using imaging mass spectrometry (2012)
  • Author(s): Satoru Miyawaki, Takahiro Hayasaka, Hideaki, Imai, Hideaki Ono, Hiroshi, Horikawa, Ochi Takashi, Akihiro Ito, Hirofumi Nakatomi, Mitsutoshi Setou, Nobuhito Saito
  • Organizer: Neuroscience 2012 SFN's 42nd annual meeting
  • Place of Presentation: ニューオリンズ(ポスター発表)
• [Presentation] イメージングマススペクトロメトリーによって初めて明らかになった、細胞内の脂質分布の分子種特異的な極性について (2012)
  • Author(s): 瀬藤光利
  • Organizer: 日本生物物理学会 第50回年会(シンポジスト)
  • Place of Presentation: 名古屋
• [Presentation] Glycolipidomics by TLC-Blot/MALDI-TOF MS- Gangliosides in Alzheimer's Disease- (2012)
  • Author(s): Takao Taki , Wakao Hirano , Takahiro Hayasaka, Mitsutoshi Setou , Naoko Goto-Inoue
  • Organizer: 26th International Carbohydrate Symposium
  • Place of Presentation: マドリード(ポスター発表)
• [Presentation] ラット損傷脊髄における炎症反応の質量顕微鏡による解析およびprostaglandinとリソリン脂質を用いた評価との比較 (2012)
  • Author(s): 花田充、杉浦悠毅、新城龍一、石黒直樹、瀬藤光利、松山幸弘
  • Organizer: 第85回 整形外科学会学術総会
  • Place of Presentation: 京都(ポスター発表)
• [Presentation] Sprague-Dawley (SD)ラット全脳虚血モデルの確立と応用(質量顕微鏡法による遅発性神経細胞死の網羅的解析) (2011)
  • Author(s): 宮脇哲、早坂孝宏、今井英明、堀川弘吏、越智崇、伊藤明博、中冨浩文、瀬藤光利、斉藤延人
  • Organizer: 第23回日本脳循環代謝学会総会
  • Place of Presentation: 都市センターホール(東京)(一般講演)
  • Year and Date: 2011-11-05
• [Presentation] 脊髄における脂質の正常及び損傷後動態の質量顕微鏡を用いた解析 (2011)
  • Author(s): 花田充、杉浦悠毅、新城龍一、石黒直樹、瀬藤光利、松山幸弘
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: ベイシア文化ホール(前橋)(一般講演)
  • Year and Date: 2011-10-20
• [Presentation] 多系統萎縮症患者脳ではγ-tubulinが減少しており、人工的γ-tubulin減少モデル動物は多系統萎縮症様の神経変性と運動失調を発症する (2011)
  • Author(s): 堤弘次, 久保亜紀子, 高木博, 赤津裕康, 紺野在, 宮本裕子, 矢尾育子, 江川潔, 佐藤尚武, 久保亮治, 安武かおり, 諸根信弘, 山内大輔, 堀尾哲也, 木村芳滋, 宮川剛, 宮嶋裕明, 福田敦夫, 塚田秀夫, 吉田眞理, 峰雪芳宣, 小西慶幸, 池上浩司, 月田早智子, 瀬藤光利
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 琉璃光(金沢)(一般講演)
  • Year and Date: 2011-09-27
• [Presentation] オーム研究と解析技術/神経 (2011)
  • Author(s): 瀬藤光利
  • Organizer: 第84回日本生化学会大会(座長・一般講演)
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2011-09-23
• [Presentation] オーム研究と解析技術/神経 (2011)
  • Author(s): 瀬藤光利
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都)(座長・一般講演)
  • Year and Date: 2011-09-23
• [Presentation] 質量顕微鏡による精神疾患研究 (2011)
  • Author(s): 瀬藤光利
  • Organizer: 第6回日本統合失調症学会(特別講演)
  • Place of Presentation: 札幌コンベンションセンター(札幌)
  • Year and Date: 2011-07-19
• [Presentation] 質量顕微鏡による精神疾患研究 (2011)
  • Author(s): 瀬藤光利
  • Organizer: 第6回日本統合失調症学会
  • Place of Presentation: 札幌コンベンションセンター(札幌)(特別講演)
  • Year and Date: 2011-07-19
• [Presentation] Distinct Distribution of Hydroxylated and Non-hydroxylated Sulfatide in Human Carebral Cortex (2011)
  • Author(s): Dai Yuuki, Yuki Sugiura, Nobuhiro Zaima, Hiroyasu Akatsu, Masami Fujiwara, Keikichi Sugiyama, Mitsutoshi Setou
  • Organizer: 59th Conference on Mass Spectrometry and Allied Topics
  • Place of Presentation: Denver(アメリカ)(ポスター発表)
  • Year and Date: 2011-06-08
• [Presentation] Simultaneouse Imaging Low Molecular Weight Metabolites in Mouse Brain Using TiO2 Nanoparticles in Nano-PALDI-IMS (2011)
  • Author(s): Kamlesh Shrivas, Takahiro Hayasaka, Yuki Sugiura, Mitsutoshi Setou
  • Organizer: 59th Conference on Mass Spectrometry and Allied Topics
  • Place of Presentation: Denver(アメリカ)(ポスター発表)
  • Year and Date: 2011-06-08
• [Presentation] Visualization of Cellular Energy Status and Oxidative Stress by using Multiple Metabolite Ions in Imaging Mass Spectrometry (2011)
  • Author(s): Yuki Sugiura, Mitsutoshi Setou
  • Organizer: 59th Conference on Mass Spectrometry and Allied Topics
  • Place of Presentation: Denver(アメリカ)(ポスター発表)
  • Year and Date: 2011-06-08
• [Presentation] 質量分析計とプロテオミクス研究の将来像 (2011)
  • Author(s): 瀬藤光利
  • Organizer: 群馬大学プロテオミクス研究会
  • Place of Presentation: 群馬
  • Year and Date: 2011-03-09
• [Presentation] 質量顕微鏡による組織イメージング (2011)
  • Author(s): 瀬藤光利
  • Organizer: 島津イメージングセミナー
  • Place of Presentation: 秋田
  • Year and Date: 2011-02-23
• [Presentation] Molecular Imaging by Mass Spectrometry (2011)
  • Author(s): Setou M
  • Organizer: The University of the Punjab
  • Place of Presentation: Pakistan
  • Year and Date: 2011-01-28
• [Presentation] Imaging Mass Spectrometry and its Data Analysis (2011)
  • Author(s): Setou M
  • Organizer: OIST seminar
  • Place of Presentation: 沖縄
  • Year and Date: 2011-01-07
• [Presentation] Multi Dimensional Mass Spectrometry Data Analysis (2011)
  • Author(s): Mitsutoshi Setou
  • Organizer: 7th Asian Biophysics Association Symposium & Annual meeting of the Indian Biophysical Society
  • Place of Presentation: India (Invited Lecture)
• [Presentation] 質量顕微鏡の開発と応用 (2011)
  • Author(s): 瀬藤光利
  • Organizer: 岡崎統合バイオ10周年記念シンポジウム
  • Place of Presentation: 岡崎
• [Presentation] Multi Dimensional Mass Spectrometry Data Analy (2011)
  • Author(s): Setou M
  • Organizer: 7th Asian Biophysics Association Symposium & Annual meeting of the Indian Biophysical Society
  • Place of Presentation: India
• [Presentation] 質量顕微鏡を用いた老化の研究 (2010)
  • Author(s): 瀬藤光利
  • Organizer: 大阪バイオサイエンス研究所
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-22
• [Presentation] 質量顕微鏡による組織イメージング (2010)
  • Author(s): 瀬藤光利
  • Organizer: 第9回バイオイメージング技術セミナー
  • Place of Presentation: 岩手
  • Year and Date: 2010-12-21
• [Presentation] 質量分析イメージング (2010)
  • Author(s): 瀬藤光利
  • Organizer: 日本分光学会ナノ分校部会第2回シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-12-10
• [Presentation] Development of Imaging Mass Spectrometry (2010)
  • Author(s): Setou M
  • Organizer: 6th International Conference on Structual Biology & Functional Genomics
  • Place of Presentation: Singapore
  • Year and Date: 2010-12-06
• [Presentation] Mass Microscopy of Glycolipid (2010)
  • Author(s): Setou M
  • Organizer: the Annual Conference of the Society for Glycobiology
  • Place of Presentation: Florida
  • Year and Date: 2010-11-07
• [Presentation] Mass Microscopy of Glycolipid (2010)
  • Author(s): Setou M
  • Organizer: Seminar at the CCRC
  • Place of Presentation: Georgia
  • Year and Date: 2010-11-04
• [Presentation] Mass Imaging (2010)
  • Author(s): Setou M
  • Organizer: Annual conference of the Korean Society of Labor atory Medicine
  • Place of Presentation: Korea
  • Year and Date: 2010-10-29
• [Presentation] Mass Microscopy revealed the polarized distribution of membrane lipids in axons (2010)
  • Author(s): Setou M
  • Organizer: The 10th Biennial Meeting of the Asia-Pacific Society for Neurochemistry
  • Place of Presentation: Phuket(タイ)
  • Year and Date: 2010-10-19
• [Presentation] Mass Microscopy revealed the polarized distribution of membrane lipids in axons (2010)
  • Author(s): Setou M
  • Organizer: The 10th Biennial Meeting of the Asia-Pacific Society for Neurochemistry
  • Place of Presentation: Phuket
  • Year and Date: 2010-10-19
• [Presentation] MSの新展開 (2010)
  • Author(s): 瀬藤光利
  • Organizer: 第35回日本医用マススペクトル学会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-09-10
• [Presentation] MALDI molecular Imaging (2010)
  • Author(s): Setou M
  • Organizer: The world Molecular Imaging Congress
  • Place of Presentation: 京都
  • Year and Date: 2010-09-08
• [Presentation] 顕微鏡の基礎・応用と新展開「生体物質同定への質量イメージング法」 (2010)
  • Author(s): 瀬藤光利
  • Organizer: 第35回組織細胞化学講習会
  • Place of Presentation: 甲府
  • Year and Date: 2010-08-05
• [Presentation] 質量顕微鏡について (2010)
  • Author(s): 瀬藤光利
  • Organizer: 積水メディカル株式会社
  • Place of Presentation: 水戸
  • Year and Date: 2010-07-28
• [Presentation] Imaging of lipid dynamics with mass spectrometry(糖脂質の質量顕微鏡観察) (2010)
  • Author(s): 瀬藤光利
  • Organizer: 第27回内藤コンファランス
  • Place of Presentation: 北海道
  • Year and Date: 2010-06-29
• [Presentation] 質量顕微鏡による細胞解析 (2010)
  • Author(s): 瀬藤光利
  • Organizer: 第20回日本サイトメトリー学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-27
• [Presentation] Development of Imaging Mass Spectrometry Instrument "Mass Microsccpe" (2010)
  • Author(s): Setou M
  • Organizer: BIT Life Sciences' 2nd Annual BioSoft-2010
  • Place of Presentation: Dalian
  • Year and Date: 2010-06-24
• [Presentation] Clinical applications of metabolite Imaging with MALDI and/or SIMS (2010)
  • Author(s): 瀬藤光利
  • Organizer: 成蹊SIMS国際シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-06-11
• [Presentation] Enhanced Visualization of Phospholipids in Animal and Plant Tissue Sections by Using Ionic Liquid Matrixes in MALDI Mass Spectrometry (2010)
  • Author(s): Shrivas K, Hayasaka T, Setou M
  • Organizer: Utah 58th ASMS Conference on Mass Spectrometry and Allied Topics
  • Place of Presentation: Salt Lake City
  • Year and Date: 2010-05-24
• [Presentation] A combined approach of imaging mass spectrometry (IMS) and capillary electrophoresis mass spectrometry (CE-MS) accomplish region-specific metabolomics during epileptic seizure. (2010)
  • Author(s): Sugiura Y, Setou M
  • Organizer: Utah 58th ASMS Conference on Mass Spectrometry and Allied Topics
  • Place of Presentation: Salt Lake City
  • Year and Date: 2010-05-24
• [Presentation] 質量顕微鏡法による代謝の可視化 (2010)
  • Author(s): 瀬藤光利
  • Organizer: 大阪大学医学部内分泌代謝内科学セミナー
  • Place of Presentation: 大阪
  • Year and Date: 2010-05-19
• [Presentation] 質量顕微鏡の開発と臨床応用 (2010)
  • Author(s): 瀬藤光利
  • Organizer: ナノ学会第8回大会
  • Place of Presentation: 岡崎
  • Year and Date: 2010-05-13
• [Presentation] Mass Microscopy : high resolution Imaging mass Spectrometry (2010)
  • Author(s): Setou M
  • Organizer: 第7回チェリーブロッサムシンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2010-04-17
• [Presentation] 質量顕微鏡法による脂質の分布の可視化 (2010)
  • Author(s): 瀬藤光利
  • Organizer: バイオロジカルシンポジウム
  • Place of Presentation: 三島
  • Year and Date: 2010-04-05
• [Presentation] Development and applications of high resolution imaging mass spectrometer under atmosphere pressure (2010)
  • Author(s): 瀬藤光利
  • Organizer: Physical Chemistry seminar
  • Place of Presentation: Penn State U
  • Year and Date: 2010-03-05
• [Presentation] 物質を見極めるための分子イメージング (2010)
  • Author(s): 瀬藤光利
  • Organizer: 近畿化学協会第31期研修塾
  • Place of Presentation: 大阪
  • Year and Date: 2010-02-06
• [Presentation] 質量顕微鏡法・イメージングマススペクトロメトリー (2010)
  • Author(s): 瀬藤光利
  • Organizer: 富山大学生命科学先端研究センター
  • Place of Presentation: 富山
  • Year and Date: 2010-02-05
• [Presentation] 質量顕微鏡法・イメージングマススペクトロメトリー (2010)
  • Author(s): 瀬藤光利
  • Organizer: 免疫学フロンティアセンター
  • Place of Presentation: 大阪
  • Year and Date: 2010-01-29
• [Presentation] 質量顕微鏡法について (2010)
  • Author(s): 瀬藤光利
  • Organizer: 富士フィルム株式会社
  • Place of Presentation: 開成
  • Year and Date: 2010-01-15
• [Presentation] 質量分析イメージングの応用 (2010)
  • Author(s): 瀬藤光利
  • Organizer: 第21回名古屋コンファレンス 21世紀をブレークスルー化学者達
  • Place of Presentation: 名古屋
  • Year and Date: 2010-01-12
• [Presentation] Mass Microscopy of Glycolipid (2010)
  • Author(s): Mitsutoshi Setou
  • Organizer: The Annual Conference of the Society for Glycobiology
  • Place of Presentation: Florida (Invited Lecture)
• [Presentation] Mass Microscopy revealed the polarized distribution of membrane lipids in axons (2010)
  • Author(s): Mitsutoshi Setou
  • Organizer: The 10th Biennial Meeting of the Asia-Pacific Society for Neurochemistry
  • Place of Presentation: Phuket (Special Lecture)
• [Presentation] TUBG2 has microtubule nucleating activity and is highly expressed in matured mammalian brain. (2010)
  • Author(s): Tsutsumi K, Yuba-Kubo A, Miyamoto Y, Horio T, Ikegami K, Yamauchi D, Mineyuki Y, Tsukita S, Konishi Y, Setou M
  • Organizer: PA 50th ASCB Annual Meeting
  • Place of Presentation: Philadelphia
• [Presentation] Imaging Mass Spectrometry Reveals Distribution of Lipids in Nervous System of Kuruma Shrimp Marsupenaeus Japonicus (2010)
  • Author(s): Chansela P, Goto-Inoue N, Soyraya M, Sobhon P, Setou M
  • Organizer: Biochemistry and Molecular Biology 2010
  • Place of Presentation: 神戸
• [Presentation] 質量顕微鏡とそのデータの統計処理法の開発 (2010)
  • Author(s): 瀬藤光利
  • Organizer: 定量生物学の会第3回年会
  • Place of Presentation: 東京
• [Presentation] 質量顕微鏡法の原理と応用 (2010)
  • Author(s): 瀬藤光利
  • Organizer: 生物物理若手の会「夏の学校」
  • Place of Presentation: 尾西
• [Presentation] Tubulin polyglutamylation is regulated by a bidirectional enzymatic system and is required for sensory behaviors of Caenorhabditis elegans (2010)
  • Author(s): Kimura Y, Kurabe N, Ikegami K, Tsutsumi K, Konishi Y, Setou M
  • Organizer: Neuro2010(第33回日本神経科学大会,第53回日本神経化学大会,第20回日本神経回路学会大会)
  • Place of Presentation: 神戸
• [Presentation] TTLL1 and TTLL7 selectively catalyze polyglutamylation of alpha- and beta-tubulins, respectively, which modulate functions of brain microtubules (2010)
  • Author(s): Konishi Y, Tsuchiya R, Ohata K, Ikegami K, Setou M
  • Organizer: Neuro2010(第33回日本神経科学大会,第53回日本神経化学大会,第20回日本神経回路学会大会)
  • Place of Presentation: 京都
• [Presentation] 質量顕微鏡法の臨床応用 (2010)
  • Author(s): 瀬藤光利
  • Organizer: 日本ヒトプロテオーム機構第8回大会(日本プロテオーム学会2010年会)・第6回日本臨床プロテオーム研究会・連合大会
  • Place of Presentation: 東京
• [Presentation] 質量分析イメージング (2010)
  • Author(s): 陣藤光利
  • Organizer: 第23回バイオメディカル分析科学シンポジウム
  • Place of Presentation: 宮城
• [Presentation] Regulatory mechanisms of tubulin polyglutamylation in C. elegans sensory cilia (2010)
  • Author(s): Kimura Y, Kurabe N, Ikegami K, Tsutsumi K, Konishi Y, Setou M
  • Organizer: 4th East Asia C.elegans Meeting
  • Place of Presentation: 東京
• [Presentation] TUBG2は哺乳類の成熟脳で高発現する微小管形成能をもつY-tubulinである (2010)
  • Author(s): 堤弘次、久保亜紀子、宮本裕子、堀尾哲也、池上浩司、山内大輔、峰雪芳宣、小西慶幸、瀬藤光利
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪
• [Presentation] ポリグルタミン酸化酵素欠損マウスにおけるニューロフィラメント分布異常 (2010)
  • Author(s): 大畑健次、小西慶幸、土屋玲子、池上浩司、瀬藤光利
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪
• [Presentation] Tubulin polyglutamylation in C.elegans sensory cilia is regulated by Ca2+ MAPK signaling pathway (2010)
  • Author(s): 木村芳滋、瀬藤光利
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪
• [Presentation] TTLL10によるヒストンシャペロンのグリシン化シグナル (2010)
  • Author(s): 池上浩司、瀬藤光利
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪
• [Presentation] Glutamylation of alpha and beta tubulins is regulated independently, and plays roles in the function of microtubules in neurons Suzhou (2010)
  • Author(s): Konishi Y, Tsuchiya R, Ohata K, Ikegami K, Setou M
  • Organizer: Cold Spring Harbor Asia Francis Crick Neuroscience Symposium meeting
  • Place of Presentation: China
• [Presentation] 質量顕微鏡の原理と応用 (2009)
  • Author(s): 瀬藤光利
  • Organizer: 第28回「生命をはかる」研究会 (公開研究会)
  • Place of Presentation: 東京
  • Year and Date: 2009-12-25
• [Presentation] Dynamic Metabolomics with Mass Spectrometry Imaging (2009)
  • Author(s): 瀬藤光利
  • Organizer: The 6th Asian Biophysical Association (ABA) Symposium
  • Place of Presentation: Hong Kong
  • Year and Date: 2009-11-14
• [Presentation] イメージングマススペクトロメトリーの進展 (2009)
  • Author(s): 瀬藤光利
  • Organizer: 第4回臨床プロテオミクス研究会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-23
• [Presentation] Newly developed mass spectrometer and diversity of tubulins (2009)
  • Author(s): 瀬藤光利
  • Organizer: Northwestern Univ
  • Place of Presentation: Chicago
  • Year and Date: 2009-10-21
• [Presentation] Diversity of tubulins analyzed with newly developed imaging mass spectometry (2009)
  • Author(s): 瀬藤光利
  • Organizer: University of North Calorina
  • Place of Presentation: north calorina
  • Year and Date: 2009-10-15
• [Presentation] Mass Microscopy (2009)
  • Author(s): 瀬藤光利
  • Organizer: Cancer Center Seminar
  • Place of Presentation: Harvard Medical School
  • Year and Date: 2009-10-14
• [Presentation] 質量顕微鏡法について (2009)
  • Author(s): 瀬藤光利
  • Organizer: 大塚製薬株式会社
  • Place of Presentation: 徳島
  • Year and Date: 2009-09-25
• [Presentation] 質量顕微鏡法による臨床分子形態学 (奨励賞 受賞講演) (2009)
  • Author(s): 瀬藤光利
  • Organizer: 第41回日本臨床分子形態学会総会・学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2009-09-04
• [Presentation] 質量顕微鏡法について (2009)
  • Author(s): 瀬藤光利
  • Organizer: ライオン株式会社
  • Place of Presentation: 東京
  • Year and Date: 2009-09-01
• [Presentation] Development and Applications of high resolution Imaging Mass Spectrometer (Mass Microscope) (2009)
  • Author(s): 瀬藤光利
  • Organizer: Korea society for mass spectrometry 2009
  • Place of Presentation: Jeju
  • Year and Date: 2009-08-27
• [Presentation] チューブリンポリグルタミン酸化と繊毛機能 (若手最優秀発表賞) (2009)
  • Author(s): 池上浩司, 瀬藤光利
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-06-04
• [Presentation] 質量分析の細胞生物学応用 (2009)
  • Author(s): 瀬藤光利
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-06-04
• [Presentation] Molecular Anatomy with Imaging Mass Spectrometry (2009)
  • Author(s): 瀬藤光利
  • Organizer: 32th AAT ANNUAL CONFERENCE
  • Place of Presentation: Thailand
  • Year and Date: 2009-04-29
• [Presentation] 質量顕微鏡法による病理観察 (2009)
  • Author(s): 瀬藤光利
  • Organizer: 奈良県立医大セミナー
  • Place of Presentation: 奈良
  • Year and Date: 2009-04-13
• [Presentation] Mass Microscopy : high resolution Imaging Mass Spectrometry (2009)
  • Author(s): 瀬藤光利
  • Organizer: The Bio-Imaging Science Symposium
  • Place of Presentation: Hong Kong
• [Presentation] Mass Microscopy ; Integration of Imaging Mass Spectrometry with Microscopy (2009)
  • Author(s): 瀬藤光利
  • Organizer: ALC'09
  • Place of Presentation: Hawaii
• [Presentation] Essential role of tubulin polyglutamylation in asymmetric cilia bending and beating (2009)
  • Author(s): Ikegami K, Sato S, Nakamura K, Setou M.
  • Organizer: 49th ASCB Annual Meeting
  • Place of Presentation: San Diego
• [Presentation] Tubulin Polyglutamylation Is Regulated by TTLL-4 Polyglutamylase Through Ca2+-MAPK Signaling Pathway (2009)
  • Author(s): Kimura Y, Setou M.
  • Organizer: 49th ASCB Annual Meeting
  • Place of Presentation: San Diego
• [Presentation] Tubulin polyglutamylation for structural and functional asymmetry of cilia (2009)
  • Author(s): Ikegami K, Sato S, Nakamura K, Setou M.
  • Organizer: ASCB/JSCB/RIKEN CDB Meeting
  • Place of Presentation: Kyoto
• [Presentation] The mechanism of axonal recognition by kinesin-I (2009)
  • Author(s): 小西慶幸, 瀬藤光利
  • Organizer: ASCB/JSCB/RIKEN CDB Meeting
  • Place of Presentation: Kyoto
• [Presentation] 微小管チロシン化による神経極性維持機構 (2009)
  • Author(s): 小西慶幸, 瀬藤光利
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] Dynamic Metiabolomics with Mass Spectrometry Imaging (2009)
  • Author(s): Setou M
  • Organizer: The 6th Asiann Biophysical Association (ABA) Sympsium
  • Place of Presentation: 香港
• [Presentation] Human Brain Pathology with Mass Spectrometry Imaging (2008)
  • Author(s): Setou M
  • Organizer: Stanley Center Seminar
  • Place of Presentation: Cambridge(イギリス)
  • Year and Date: 2008-12-10
• [Presentation] Human Brain Pathology with Mass Spectrometry Imaging (2008)
  • Author(s): Setou M
  • Organizer: Stanley Center Seminar
  • Place of Presentation: Cambridge
  • Year and Date: 2008-12-10
• [Presentation] Mass Imaging of Dynamic Metabolomics in Kainate signaling (2008)
  • Author(s): Setou M
  • Organizer: Gordon Research Conferences Molecular and Cellular Neurobiology
  • Place of Presentation: Hong Kong(中国)
• [Presentation] Human Brain Pathology with Mass Spectrometry Imaging (2008)
  • Author(s): Mitsutoshi Setou
  • Organizer: MIT Stanley Center Seminar
  • Place of Presentation: Cambridge (Special Lecture)
• [Presentation] Mass Imaging of Dynamic Metabolomics in Kainate signaling (2008)
  • Author(s): Mitsutoshi Setou
  • Organizer: Gordon Research Conferences Molecular and Cellular Neurobiology
  • Place of Presentation: Hong Kong (Invited Lecture)
• [Presentation] Mass Imaging OF Dynamic Metabolomics in Kainate signaling (2008)
  • Author(s): Setou M
  • Organizer: Gordon Research Conferences Molecular and Cellular Neurobiology
  • Place of Presentation: 香港
• [Book] 実験医学 時間的・空間的な生命現象理解のための最新テクノロジー (2010)
  • Author(s): 瀬藤光利
  • Total Pages: 4
  • Publisher: 羊土社
• [Book] Imaging Mass Spectrometry; Protocols for Mass Microscopy (2010)
  • Author(s): Setou M
  • Total Pages: 262
  • Publisher: Springer
• [Book] Imaging Mass Spectrometry : Protocols for Mass Microscopy. (2010)
  • Author(s): Setou M. Ed.
  • Publisher: Springer
• [Book] 実験医学 28巻 1号(時間的・空間的な生命現象理解のための最新テクノロジー) (2010)
  • Author(s): 瀬藤光利
• [Book] 実験医学時間的・空間的な生命現象理解のための最新テクノロジー (2010)
  • Author(s): 瀬藤光利
  • Total Pages: 4
  • Publisher: 羊土社
• [Book] Imaging Mass Spectrometry ; Oriticols or Mass Micromscopy-新版 質量顕微鏡法実験プロトコール- (2010)
  • Author(s): Mitsutoshi Setou Ed.
  • Total Pages: 262
  • Publisher: シュプリンガー・ジャパン株式会社
• [Book] 質量顕微鏡法:イメージングマススペクトロメトリー 実験プロトコール (2008)
  • Author(s): 瀬藤光利
  • Total Pages: 189
  • Publisher: シュプリンガー・ジャパン株式会社
• [Book] 質量顕微鏡法:イメージングマススペクトロメトリー実験プロトコール (2008)
  • Author(s): 瀬藤光利編
  • Publisher: シュプリンガー・ジャパン
• [Book] 質量顕微鏡法 : イメージングマススペクトロメトリー実験プロトコ-ノレ (2008)
  • Author(s): 瀬藤光利編
  • Total Pages: 189
  • Publisher: シュプリンガー・ジャパン
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