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Clarification of the mechanisms to control odor-evoked responses using genetically manipulated mice with neuronal modifications.

Research Project

Project/Area Number 20680019
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionThe University of Tokyo

Principal Investigator

KOBAYAKAWA Ko  The University of Tokyo, 神経機能学部門, 研究員 (60466802)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2008: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Keywords行動神経科学 / 神経回路の改変 / 恐怖行動 / 社会行動 / 情動
Research Abstract

In this study, we found that specific neuronal circuits in the main olfactory system which start from distinct area on the dorsal-domain of the olfactory bulb regulate various social communication responses in addition to fear responses. Various kinds of genetically manipulated mice with partial depletions of the specific neuronal circuits in the main olfactory system were generated, and quantitative analysis systems for odor-evoked specific behaviors and emotions were constructed. From these results, we established the methods to study the neuronal mechanisms to regulate odor-evoked responses based on the functions of the specific neuronal circuits in the main olfactory bulb.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (23 results)

All 2010 2009 2008 Other

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (8 results) Book (4 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] 哺乳類の匂いに対する情動を先天的に制御する神経回路の発見2010

    • Author(s)
      小早川高、小早川令子
    • Journal Title

      医学の歩み 1

      Pages: 19-29

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Pre-target axon sorting establishes the neural map topography2009

    • Author(s)
      Imai T, Yamazaki T, Kobayakawa R, Kobayakawa K, Abe T, Suzuki M, Sakano H.
    • Journal Title

      Science 325

      Pages: 585-590

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pre-target axon sorting establishes the neural map topography2009

    • Author(s)
      Imai T et al.
    • Journal Title

      Science 325

      Pages: 585-590

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 匂いに対する先天的な忌避行動を制御する神経回路2008

    • Author(s)
      小早川高、小早川令子
    • Journal Title

      細胞工学 Vol.27

      Pages: 1131-1138

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Spatial arrangement of glomerular molecular-feature clusters in the odorant-receptor-class domains of the mouse olfactory bulb

    • Author(s)
      Matsumoto H, Kobayakawa K, Kobayakawa R, Tashiro T, Mori K, Sakano H, Mori K.
    • Journal Title

      J Neurophysiol (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatial arrangement of glomerular molecular-feature clusters in the odorant-receptor-class domains of the mouse olfactory bulb

    • Author(s)
      Matsumoto H et al.
    • Journal Title

      J Neurophysiol (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Neural mechanisms to cotrol odor-evoked emotions and behaviors2009

    • Author(s)
      小早川高
    • Organizer
      第31回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 嗅覚入力による快・不快情動生成と他感覚入力への影響2009

    • Author(s)
      小早川高
    • Organizer
      平成21年度生理学研究所研究会(感覚刺激・薬物による不快情動生成機構とその破綻)
    • Place of Presentation
      生理学研究所
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neural Mechanisms to control odor evoked emotion and behaviors2009

    • Author(s)
      小早川高
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 嗅覚入力による快・不快情動生成と他感覚入力への影響2009

    • Author(s)
      小早川高
    • Organizer
      平成20年度生理学研究所研究会
    • Related Report
      2009 Final Research Report
  • [Presentation] 匂い分子が引き起こす嫌悪感や恐怖感を先天的に制御する神経回路2008

    • Author(s)
      小早川高
    • Organizer
      平成20年度生理学研究所研究会
    • Related Report
      2009 Final Research Report
  • [Presentation] Molecular feature clusters of glomeruli in the odorant receptor class domains of the mouse olfactory bulb2008

    • Author(s)
      松本英之、小早川高、小早川令子、坂野仁、森憲作
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2009 Final Research Report
  • [Presentation] Possible roles of dorsal-zone olfactory neurons in regulating innate social behaviors in mice2008

    • Author(s)
      小早川令子
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular feature clusters of glomerulus in the odorant receptor class domains of the mouse olfactory bulb2008

    • Author(s)
      松本英之
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2008 Annual Research Report
  • [Book] 入門構造生物学2010

    • Author(s)
      小早川高, 小早川令子
    • Publisher
      共立出版
    • Related Report
      2009 Final Research Report
  • [Book] 医学のあゆみ2010

    • Author(s)
      小早川高, 小早川令子
    • Publisher
      医歯薬出版
    • Related Report
      2009 Final Research Report
  • [Book] Aroma Research2009

    • Author(s)
      小早川高, 小早川令子
    • Publisher
      フレグランスジャーナル社
    • Related Report
      2009 Final Research Report
  • [Book] 細胞工学2008

    • Author(s)
      小早川高、小早川令子
    • Publisher
      秀潤社
    • Related Report
      2009 Final Research Report
  • [Remarks] 第13回東京大学理学公開講演会猫を怖がらないマウスが教える心の仕組み東京大学駒場キャンパス(2008年5月10日)

    • Related Report
      2009 Final Research Report
  • [Remarks] 生化若手の会2009夏の学校若手ワークショップ猫を怖がらないマウスが教える心の仕組み神戸セミナーハウス(2009年8月28日)

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 動物用忌避剤2010

    • Inventor(s)
      小早川高、小早川令子
    • Industrial Property Rights Holder
      小早川高、小早川令子
    • Industrial Property Number
      2010-025681
    • Filing Date
      2010-02-08
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 動物用忌避剤2010

    • Inventor(s)
      小早川高, 小早川令子
    • Industrial Property Rights Holder
      小早川高, 小早川令子
    • Industrial Property Number
      2010-025681
    • Filing Date
      2010-02-08
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 体重調節作用を有する物質の検出方法および不安行動に影響を及ぼす物質の検出方法ならびにそれらに使用する動物2008

    • Inventor(s)
      小早川令, 子小早川高
    • Industrial Property Rights Holder
      小早川令, 子小早川高
    • Filing Date
      2008-07-09
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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