Upgrading of an information infrastructure for Japanese genome diversity using haploid DNA materials
Project/Area Number |
20681020
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
基礎ゲノム科学
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Research Institution | Kyushu University |
Principal Investigator |
KUKITA Yoji Kyushu University, 研究所, 研究員 (60372744)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2008: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
|
Keywords | ゲノム多様性 / ハプロタイプ / ゲノム / 遺伝子 / 癌 |
Research Abstract |
We determined SNP/CNV haplotype structures by analyzing 100 complete hydatidiform moles from Japanese subjects via high-density DNA arrays. The obtained haplotype is useful as a reference for the haplotype structure of Japanese population. Furthermore, using SNP/CNV information, we analyzed one lung cancer sib-pair by whole-exome sequencing, and identified a causative CHEK2 mutation that makes the functional protein unstable.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Impact of group IVA cytosolic phospholipase A2 gene polymorphisms on phenotypic features of patients with familial adenomatous polyposis.2010
Author(s)
Umeno J, Matsumoto T, Esaki M, Kukita Y, Tahira T, Yanaru-Fujisawa R, Nakamura S, Arima H, Hirahashi M, Hayashi K, Iida M.
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Journal Title
International Journal of Colorectal Disease 25
Pages: 293-301
Related Report
Peer Reviewed
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[Journal Article] Prevalence of copy-number neutral LOH in glioblastomas revealed by genomewide analysis of laser-microdissected tissues.2008
Author(s)
Kuga D, Mizoguchi M, Guan Y, Hata N, Yoshimoto K, Shono T, Suzuki SO, Kukita Y, Tahira T, Nagata S, Sasaki T, Hayashi K.
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Journal Title
Neuro Oncology 10
Pages: 995-1003
Related Report
Peer Reviewed
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[Journal Article] Narrowing of the regions of allelic losses of chromosome 1p36 in meningioma tissues by an improved SSCP analysis.2008
Author(s)
Guan Y, Hata N, Kuga D, Yoshimoto K, Mizoguchi M, Shono T, Suzuki SO, Tahira T, Kukita Y, Higasa K, Yokoyama N, Nagata S, Iwaki T, Sasaki T, Hayashi K.
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Journal Title
International Journal of Cancer 122
Pages: 1820-1826
Related Report
Peer Reviewed
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