Studies on the Transition Metal-Rare Earth Metal/Dinuclear Schiff Base Catalysts, Mechanistic Studies and Application to New Asymmetric Reactions
| Project/Area Number |
20685008
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2008: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 触媒 / 不斉合成 / 不斉触媒 / サレン / 非天然アミノ酸 / 医薬品合成 / 希土類触媒 / シッフ塩基 / 複核錯体 |
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| Research Abstract |
Characterization of hetero-dinuclear rare earth metal/transition metal Schiff base complexes, as well as their applications to various enantioselective reactions have been investigated. Catalytic asymmetric nitro-Mannich-type reactions, catalytic asymmetric α-addition of isocyanato esters to aldehydes, and so on have been successfully developed, leading to providing useful synthetic methods for chiral nitrogen-containing building blocks. Thus, the achievement can contribute for the efficient synthesis of pharmaceuticals.
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Report
(4 results)
Research Products
(25 results)
