| Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2009: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2008: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Research Abstract |
In order to track germinal center B cell differentiation in antibody responses, a reporter mouse was established to quantify BCL6 protein expression in live cells. Two-photon imaging experiments revealed that migration of differentiating B cells and helper T cells into the germinal center was impaired by attenuated function of BCL6. In addition, integrins were shown to be involved in conjugation of cognate antigen-engaged B cells and T cells in the lymph node, and the stromal cell network was suggested to be important for migration of the B-T conjugates.
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