Research Project
Grant-in-Aid for Young Scientists (A)
We conducted two lines of research, which aim at elucidating the mechanisms of regulatory T cell (Treg) differentiation and function. First, we asked whether and how naturally occurring Foxp3 gene mutations identified in human IPEX affect Treg differentiation and function by generating knock-in mice. We found that one of the mutations resulted in the development of autoimmune diseases similar to human IPEX, which was associated with a selective deficiency of a "tissue-seeking" subset of Treg cells. These results suggest that Foxp3+ Treg cells consist of functionally distinct subsets, each of which may play non-redundant roles in the establishment and maintenance of self-tolerance. Second, we found that Foxp3^+ T cells are heterogeneous in that they contain a minor, functionally uncommitted, plastic subpopulation that loses Foxp3 expression and converts to helper T cells in response to environmental perturbations.
All 2011 2010 2009 2008 Other
All Journal Article (25 results) (of which Peer Reviewed: 24 results) Presentation (23 results) Remarks (1 results)
J.Dermatol.Sci. 61
Pages: 144-147
10030890224
Science 331
Pages: 337-341
Journal of Dermatological Science
Volume: 61 Pages: 144-147
Science
Volume: 331 Pages: 337-341
Curr.Opin.Immunol.y 22
Pages: 575-582
J.Clin.Invest. 120
Pages: 883-893
Immunol.Lett. 128
Pages: 108-115
Eur.J.Immunol. 40
Pages: 664-667
Current Opinion in Immunology
Volume: 22 Pages: 575-582
European Journal of Immunology (印刷中)
Immunology Letters (印刷中)
Journal of Clinical Investigation (印刷中)
J.Immunol. 183
Pages: 7631-7634
Science 323
Pages: 1488-1492
PNAS 106
Pages: 1903-1908
Journal of Immunology 183
Science (in press)
Proceedingd of the National Academy of Sciences of the United States of America (PNAS) 106
Int.Immunol. 20
Pages: 1231-1237
10022599696
J.Biol.Chem. 283
Pages: 17003-17008
Eur.J.Immunol. 38
Pages: 928-930
International Immunology 20
Journal of Biological Chemistry 283
European Journal of Immunology 38
分子細胞治療 7(3)
Pages: 115-120
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