Examination of chemokine roles in CLP-induced sepsis model and its application for forensic diagnosis
| Project/Area Number |
20689015
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
ISHIDA Yuko 和歌山県立医科大学, 医学部, 講師 (10364077)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
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| Keywords | 敗血症 / 法医診断学 / ケモカイン / マウス / cecal ligation and puncture(CLP) / cecal ligation puncture / cecal ligation and puncture / ケモカイーン |
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| Research Abstract |
We examined CCR2 and CX3CR1 expression in sepsis-induced lung injury. Morphometrically, the average of CCR2-and CX3CR1-positive macrophages was significantly increased in sepsis group compared with control group in double-color immunofluorescence analysis. Immunohistochemical detection of CCR2 and CX3CR1 expression in the lungs can be considered as valuable diagnostic tools for the postmortem diagnosis of sepsis.
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Report
(6 results)
Research Products
(8 results)
