Analysis of Sec63 conditional knockout mice
| Project/Area Number |
20689017
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
NISHIO Saori Hokkaido University, 北海道大学病院, 助教 (90463736)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 常染色体優性多発性嚢胞腎 / 常染色体優性遺伝性肝嚢胞 / Sec63 / アポトーシス / 細胞増殖 / cilia / 水腎症 / 常染色体優性多発性肝嚢胞 / Pkd2 / Pkd1 |
|---|
| Research Abstract |
I elucidated the mechanism of cystformation in autosomal dominant polycystic liver disease by analysis of Sec63 conditional knockout mice. I also elucidated one of the function of Sec63. Sec63 is strongly associated with apoptosis.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] A murin model of neonatal diabetes mellitus in Glis3-deficent mice2009
Author(s)
Watanabe N, Hiramatsu K, Miyamoto R, Yasuda K, Suzuki N, Oshima N, Kiyonari H, Shiba D, Nishio S, Mochizuki T, Yokoyama T, Maruyama S, Matsuo S, Wakamatsu Y, Hashimoto H.
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Journal Title
FEBS Lett. 583
Pages: 2108-2113
Related Report
Peer Reviewed
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[Journal Article] Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkdl2008
Author(s)
Shibazaki S, Yu Z, Nishio S,Tian X, Brent T, Mitobe M, Louvi A, Ve lazquez H, Ishibe S, Cantley G, Ig arashi P, Somlo S
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Journal Title
Human Moleculer Genetics 17
Pages: 1505-1516
Related Report
Peer Reviewed
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