Energy metabolism and pathophysiological role of AMPK-related kinase in adipocytes and skeletal muscle cells.

• Project/Area Number: 20689018
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Endocrinology
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: SUZUKI Atsushi National Institute for Physiological Sciences, 臨床薬理研究部, 特任研究員 (50418993)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000); Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2008: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
• Keywords: ARK5 / 脂肪細胞 / 骨格筋 / 糖尿病 / 肥満 / AMPK / 代謝ストレス / 炎症 / 細胞生存

Research Abstract

Expression and role of AMPK-related kinase, ARK5, in skeletal muscle cells and adipocytes were analyzed. In skeletal muscle cell, ARK5 promotes insulin-induced glucose uptake. Addition to muscular ARK5, I showed that ARK5 expressed in white adipose tissue (WAT) of obese animals and that promotes WAT hypertrophy and inflammation via its cell survival promotion-activity.

Research Products

• [Journal Article] Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. (2009)
  • Author(s): Toda, C., Shiuchi, T., Lee, S., Yamato-Esaki, M., Fujino, Y., Suzuki, A., Okamoto, S., Minokoshi Y.
  • Journal Title: Diabetes 58 Pages: 2757-2765
  • Peer Reviewed
• [Journal Article] Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. (2009)
  • Author(s): 戸田知得
  • Journal Title: Diabetes 58 Pages: 2757-2765
  • Peer Reviewed
• [Journal Article] Nuclear localization of SNARK: Its implication on gene expression. Biochem. (2008)
  • Author(s): Kuga, W., Tsuchihara, K., Ogura, T., Kanehara, S., Saito, M., Suzuki, A., Esumi H.
  • Journal Title: Biophys. Res. Commun. 377 Pages: 1062-1066
  • Peer Reviewed
• [Journal Article] Overexpression of carboxyesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irrinotecan (CPT-11), for multiple myeloma. (2008)
  • Author(s): Iida, S., Yano, H., Kayukawa, S., Nakagawa, C., Oguri, T., Ding, J., Mori, F., Ito, A., Ri, M., Inagaki, A., Kusumoto, S., Ishida, T., Komatsu, H., Inagaki, H., Suzuki, A., Ueda, R.
  • Journal Title: Cancer Sci. 99 Pages: 2309-2314
  • Peer Reviewed
• [Presentation] AMPK family member ARK5 is essential for white adipose tissue hypertrophy in response to high-fat diet feeding (2009)
  • Author(s): Suzuki, A., Lee, S., Okamoto, S., Shiuchi, T., Minokoshi, Y.
  • Organizer: he 36th Congress of the International Union of Physiological Sciences (IUPS2009)
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Presentation] AMPK family member ARK5 is essential for white adipose tissue hypertrophy in response to high-fat diet feeding. (2009)
  • Author(s): 鈴木敦
  • Organizer: The 36^<th> Congress of the International Union of Physiological Seiences
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Presentation] ARK5の細胞生存活性は高脂肪食摂取による脂肪組織の肥大・増殖を促進する (2008)
  • Author(s): 鈴木敦
  • Organizer: 第29回日本肥満学会
  • Place of Presentation: 大分
  • Year and Date: 2008-10-18
• [Presentation] ARK5の細胞生存活性は高脂肪食摂取による脂肪組織の肥大・増殖を促進する (2008)
  • Author(s): 鈴木敦、李順姫、岡本士毅、大和摩耶、藤野裕介、戸田知得、志内哲也、2、泰江慎太郎、益崎裕章、中尾一和、箕越靖彦
  • Organizer: 第29回日本肥満学会総会
  • Place of Presentation: 大分
  • Year and Date: 2008-10-17
• [Book] アディポサイエンス(特集:糖尿病とアディポサイエンスUpdate) (2009)
  • Author(s): 鈴木敦、箕越靖彦
  • Publisher: フジメディカル出版
• [Book] 糖尿病ナビゲーター(改訂版) (2009)
  • Author(s): 鈴木敦
  • Publisher: メディカルレビュー社(印刷中)
• [Book] アディポサインス (2009)
  • Author(s): 鈴木敦
  • Publisher: フジメディカル出版社(印刷中)
• [Book] 糖尿病ナビゲーター(改訂版)
  • Author(s): 鈴木敦、箕越靖彦
  • Publisher: メディカルレビュー社(印刷中)
• [Remarks] 研究所HP :
  • URL: http://www.nips.ac.jp/
• [Remarks] 研究室HP :
  • URL: http://www.nips.ac.jp/endoclin/