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Magnetic resonance influenced (MRI) ovarian organ freezing and transplant for iatrogenic sterility of cancer therapy.

Research Project

Project/Area Number 20689020
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionThe University of Tokyo

Principal Investigator

MIHARA Makoto  The University of Tokyo, 医学部附属病院, 助教 (90384833)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Keywords超微小血管外科 / 磁場下過冷却凍結 / 卵巣凍結 / 子宮移植 / 妊孕性温存 / 妊孕性再建 / 小児癌 / 小児がん / がん治療後QOL / 過冷却凍結 / 生殖医療 / 臓器移植 / 食品凍結技術 / 磁場環境下凍結
Research Abstract

(Background)Chemotherapy and radiotherapy are essential for treatment of cancer in children and young adults, but these methods often result in testicular failure or reduced ovarian function. One problem in this area is that the ovum is structurally weak, compared with sperm, and the pregnancy rate after frozen ovum storage is very low. Ovarian preservation might be performed before cancer therapy and, in particular, may offer hope for preservation of fertility in young women with cancer.(Method)We hypothesize that this is due to instability of blood flow, and to examine this possibility we have focused on the vascular system and cryopreservation of 5 rats and 2 cynomolgus monkey with MRI whole organ freezing method, magnetic resonance influenced. We are examining the potential of this technology in transplantation and cryopreservation of the ovary.(Result)We attempted transplantation of a vascularized ovary following a certain period of cryopreservation. The endocrine function of the ovary and the potential for pregnancy were permanently re-acquired following these procedure.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (42 results)

All 2010 2009 2008 2007 2005 Other

All Journal Article (34 results) (of which Peer Reviewed: 33 results) Presentation (2 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Whole Ovary Cryopreservation Applying Supercooling under Magnetic Field(変動磁場下過冷却凍結によるブタ卵巣凍結と卵子生存率解析)2010

    • Author(s)
      T Niino, Takashi Nakagawa, Shuhei Noguchi, Tatsuro Kawai, Takeyoshi Dohi, Mihara M
    • Journal Title

      ACSC. 1(2)(in print)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of Pathology Specimen preparation Method by Supercooling Cryopreservation under Magnetic Field. (変動磁場下過冷却凍結による病理凍結切片作成法の技術開発)2010

    • Author(s)
      Mihara M, Nakagawa T, Noguchi S, Fujii K, Owada T, Niino T.
    • Journal Title

      ACSC. 1(2)(in print)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Supermicrosurgery and Head and Neck Reconstruction in Children. (超微小外科技術を応用した小児頭頚部再建法の開発)2010

    • Author(s)
      Mihara M, Takuya Iida,, Takahiro Asakage2, Kensuke Kawai3
    • Journal Title

      ACSC. 1(2)(in print)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of New Composite Tissue Allotransplantation Models. (実験動物における新しい複合組織移植モデル開発)2010

    • Author(s)
      Takumi Yamamoto, Mihara M, Mitsunaga Narushima1, Isao Kohshima1
    • Journal Title

      ACSC. 1(2)(in print)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possibility of Application of Metabolomics Analysis for Supermicro Surgery on Children. (小児再建手術における遊離皮弁の皮弁代謝解析と術後モニタリング確立)2010

    • Author(s)
      Mihara M, Hisako Hara, Mitsunaga Narushima1, Takuya Iida1, Takuya Higashino1, Gentaro Isao Koshima
    • Journal Title

      ACSC. 1(2)(in print)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biometrics and Identification System Using Information from the Physical Features. (耳介を用いた個人認証技術の開発)2010

    • Author(s)
      Mihara M, Takashi Nakagawa, Shuhei Noguchi
    • Journal Title

      ACSC. 1(2)(in print)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The intravascular stenting method for treatment of extremity lymphedema with multiconfiguration lymphaticovenous anastomoses. (リンパ管静脈吻合術における血管内ステント法の有用性)2010

    • Author(s)
      Narushima M, Mihara M, Yamamoto Y, Iida T, Koshima I, Mundinger GS.
    • Journal Title

      Plast Reconstr Surg 125(3)

      Pages: 935-43

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Whole Ovary Cryopreservation Applying Supercooling under Magnetic Field2010

    • Author(s)
      Toyotaro Niino, Takashi Nakagawa, Shuhei Noguchi, Ikuma Sato, Tatsuro Kawai, Hiromasa Yamashita, Ken Masamune Takeyoshi Dohi, Makoto Mihara
    • Journal Title

      Academic Collaborations for Sick Children 2(in press)

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Pathology Specimen Preparation Method by Supercooling Cryopreservation under Magnetic Field2010

    • Author(s)
      Takashi Nakagawa, Makoto Mihara, Shuhei Noguchi, Kazuhiro Fujii, Tetsuo Ohwada, Toyotaro Niino, Ikuma Sato, Hiromasa Yamashita, Ken Masamune, Takeyoshi Dohi
    • Journal Title

      Academic Collaborations for Sick Children 2(in press)

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential of vascularized spinal cord transplantation for pediatric central nervous system tumors2010

    • Author(s)
      Kazuki Kikuchi, Makoto Mihara, Mitsunaga Narushima, Takuya Iida, Gentaro Uchida, Isao Koshima
    • Journal Title

      Academic Collaborations for Sick Children 2(in press)

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Supermicrosurgery and Head and Neck Reconstruction in Children2010

    • Author(s)
      Takuya Iida, Makoto Mihara, Takahiro Asakage, Kensuke Kawai
    • Journal Title

      Academic Collaborations for Sick Children 2(in press)

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of New Composite Tissue Allotransplantation Models using supermicrosurgey2010

    • Author(s)
      Takumi Yamamoto, Makoto Mihara, Mitsunaga Narushima, Isao Kohshima
    • Journal Title

      Academic Collaborations for Sick Children 2(in press)

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possibility of Application of Metabolomics Analysis for Supermicro Surgery on Children2010

    • Author(s)
      Kazuki Kikuchi, Makoto Mihara, Mitsunaga Narushima, Takuya Iida, Gentaro Uchida, Isao Koshima
    • Journal Title

      Academic Collaborations for Sick Children 2(in press)

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biometrics and Identification System Using Information from the Physical Features2010

    • Author(s)
      Makoto Mihara, Takashi Nakagawa, Shuhei Noguchi
    • Journal Title

      Academic Collaborations for Sick Children 2(in press)

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Super-microsurgery for vascularized ovarian transplantation. (超微小外科技術を用いたラット卵巣移植モデルの開発)2009

    • Author(s)
      Ong WC, Nakagawa T, Noguchi S, Mihara M.
    • Journal Title

      ACSC. 1(1)

      Pages: 30-33

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] MRI, Magnetic resonance influenced, organ freezing methd under magnetic field. (磁場下過冷却凍結技術を用いた臓器凍結後の組織科学的検討)2009

    • Author(s)
      Mihara M (correspondence), Nakagawa T, Noguchi S, Fujii K, Ohwada T, Kawai T.
    • Journal Title

      ACSC. 1(1)

      Pages: 34-37

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Temporary ovarian transplantation for iatrogenic sterility. (医原性不妊症解決のための一時的卵巣移植法の開発)2009

    • Author(s)
      Fukushima T, Nakagawa T, Noguchi S, Mihara M.
    • Journal Title

      ACSC. 1(1)

      Pages: 38-41

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Super-Microsurgery for testis organ transplantation and cryopreservation. (超微小外科技術を用いたラット精巣移植モデルの開発)2009

    • Author(s)
      Samanpachin K, Nakagawa T, Noguchi S, Mihara M.
    • Journal Title

      ACSC. 1(1)

      Pages: 42-45

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Uterus transplatation and ovarian cryopreservation for fertility reconstruction. (妊孕性再建のための子宮移植モデル開発)2009

    • Author(s)
      Halim AS, Nakagawa T, Noguchi S, Mihara M.
    • Journal Title

      ACSC. 1(1)

      Pages: 46-49

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross-face nerve transfer for established trigeminal branch II palsy. (顔面神経麻痺に対する血管柄付神経移植法の開発)2009

    • Author(s)
      Koshima I, Narushima M, Mihara M, Uchida G, Nakagawa M.
    • Journal Title

      Ann Plast Surg 63(6)

      Pages: 621-3

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Digital artery perforator (DAP) flaps: modifications for fingertip and finger stump reconstruction. (指尖部再建のための指動脈穿通枝皮弁開発)2009

    • Author(s)
      Mitsunaga N, Mihara M, Koshima I, Gonda K, Takuya I, Kato H, Araki J, Yamamoto Y, Yuhei O, Todokoro
    • Journal Title

      J Plast Reconstr Aesthet Surg

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fascicular turnover flap for nerve gaps. (神経欠損に対する神経反転法の臨床応用)2009

    • Author(s)
      Koshima I, Narushima M, Mihara M, Uchida G, Nakagawa M.
    • Journal Title

      J Plast Reconstr Aesthet Surg

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intravascular stenting (IVaS) method for fingertip replantation. (指尖部再接着術における血管内ステント法の有用性)2009

    • Author(s)
      Narushima M, Mihara M, Koshima I, Gonda K, Takuya I, Kato H, Nakanishi K, Yamamoto Y, Araki J
    • Journal Title

      Ann Plast Surg 62(1)

      Pages: 38-41

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Super-Microsurgery for vascularized ovarian transplantation2009

    • Author(s)
      Wei Chen Ong, Takashi Nakagawa, Shuhei Noguchi, Makoto Mihara
    • Journal Title

      Academic Collaborations for Sick Children 1

      Pages: 30-33

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MRI, Magnetic resonance influenced, organ freezing method under magnetic field2009

    • Author(s)
      Makoto Mihara, Takashi Nakagawa, Shuhei Noguchi, Kazuhiro Fujii, Tetsuo Ohwada, Tatsuro Kawai
    • Journal Title

      Academic Collaborations for Sick Children 1

      Pages: 34-37

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporary ovarian transplantation for iatrogenic sterility2009

    • Author(s)
      Takako Fukushima, Takashi Nakagawa, Shuhei Noguchi, Makoto Mihara
    • Journal Title

      Academic Collaborations for Sick Children 1

      Pages: 38-41

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Super-Microsurgery for testis organ transplantation and cryopreservation2009

    • Author(s)
      Kanit Samanpachin, Takashi Nakagawa, Shuhei Noguchi, Makoto Mihara
    • Journal Title

      Academic Collaborations for Sick Children 1

      Pages: 42-45

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uterus transplantation and ovarian cyopreservation for fertility reconstruction2009

    • Author(s)
      Halim Ahmad Sukari, Takashi Nakagawa, Shuhei Noguchi, Makoto Mihara
    • Journal Title

      Academic Collaborations for Sick Children 1

      Pages: 46-49

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utility and anatomical examination of the DIEP flap's three-dimensional image with multidetector computed tomography. (MDCTを用いた皮下脂肪の微小血管解剖解析)2008

    • Author(s)
      Mihara M(correspondence), Nakanishi M, Nakashima M, Narushima M, Koshima I.
    • Journal Title

      Plast Reconstr Surg 122(1)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distal phalanx replantation using the delayed venous method: a high success rate in 21 cases without specialised technique. (超微小外科を用いた指尖部再接着手術21症例)2008

    • Author(s)
      Mihara M(correspondence), Nakanishi M, Nakashima M, Narushima M, Gonda K, Koshima I.
    • Journal Title

      J Plast Reconstr Aesthet Surg 61(1)

      Pages: 88-93

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Short pedicle thoracodorsal artery perforator (TAP) adiposal flap for three-dimensional reconstruction of contracted orbital cavity. (胸壁穿通枝皮弁による眼科再建術式の開発)2008

    • Author(s)
      Koshima I, Narushima M, Mihara M, Uchida G, Nakagawa M.
    • Journal Title

      J Plast Reconstr Aesthet Surg

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intravascular stenting (IVaS) for safe and precise supermicrosurgery. (血管内ステント法を用いた超微小血管吻合法の開発)2008

    • Author(s)
      Narushima M, Koshima I, Mihara M, Uchida G, Gonda K.
    • Journal Title

      Ann Plast Surg 60(1)

      Pages: 41-4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intraoperative lymphography using indocyanine green dye for near- infrared fluorescence labeling in lymphedema. (ICGを用いたリンパ管造影法の開発)2007

    • Author(s)
      Ogata F, Narushima M, Mihara M, Azuma R, Morimoto Y, Koshima I.
    • Journal Title

      Ann Plast Surg 59(2)

      Pages: 180-4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of lymphedema with lymphaticovenular anastomoses. (超微小血管外科技術を用いたリンパ管静脈吻合術開発)2005

    • Author(s)
      Nagase T, Gonda K, Inoue K, Higashino T, Fukuda N, Gorai K, Mihara M, Nakanishi M, Koshima I.
    • Journal Title

      Int J Clin Oncol 10(5)

      Pages: 304-10

    • Related Report
      2009 Final Research Report
  • [Presentation] 超微小血管外科技術を用いた小児眼科者の妊孕性温存研究2009

    • Author(s)
      三原誠
    • Organizer
      小児癌学会
    • Place of Presentation
      東京ベイホテル東急
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 超微小血管外科技術を用いた小児眼科者の妊孕性温存研究2009

    • Author(s)
      三原誠
    • Organizer
      小児癌学会等
    • Place of Presentation
      東京その他
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://gakujutu.umin.jp/English/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.h.u-tokyo.ac.jp/plastic/mihara.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://gakujutu.umin.jp/English/index.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.h.u-tokyo.ac.jp/plastic/mihara.html

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 凍結方法2009

    • Inventor(s)
      三原誠、中川毅史、野口修平
    • Industrial Property Rights Holder
      三原誠
    • Industrial Property Number
      2009-256748
    • Filing Date
      2009-11-10
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 生体情報モニタリングシステム2009

    • Inventor(s)
      三原誠、中川毅史、野口修平
    • Industrial Property Rights Holder
      三原誠
    • Industrial Property Number
      2009-122245
    • Filing Date
      2009-05-21
    • Related Report
      2009 Annual Research Report 2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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