Integrative genomic analyses for understanding the systematic gene expression changes in the brains of patients with psychiatric disorders
Project/Area Number |
20689022
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Psychiatric science
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
IWAMOTO Kazuya The Institute of Physical and Chemical Research, 医学部附属病院, 特任准教授 (40342753)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
Keywords | エピジェネティクス / DNAメチレーション / 統合失調症 / 双極性障害 / 精神疾患 / 死後脳 / DNAメチル化 / 遺伝子発現 |
Research Abstract |
We have profiled single nucleotide polymorphism pattern, copy number variations, and DNA methylation pattern in the postmortem brains of patients with mental disorders. We then linked the genetic/epigenetic variations to gene expression changes in the brain.
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Report
(4 results)
Research Products
(70 results)
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[Presentation] Comprehensive DNA methylation analysis in the human brain and its application to psychiatric diseases.
Author(s)
Iwamoto K, Bundo M, Ueda J, Nakano Y, Oldham MC, Ukai W, Hashimoto E, Saito T, Geschwind DH, Kato T.
Organizer
The 17th World Congress of Psychiatric Genetics
Place of Presentation
Manchester Grand Hyatt, SanDiego
Related Report
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