Development of molecular imaging probes for β-amyloid and tau in Alzheimer's disease
Project/Area Number |
20689023
|
Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Radiation science
|
Research Institution | Kyoto University |
Principal Investigator |
ONO Masahiro Kyoto University, 薬学研究科, 准教授 (80336180)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
|
Keywords | 放射性医薬品 / 造影剤 / アルツハイマー病 / アミロイドβ / タウ / PET / SPECT / イメージング / 診断 / βアミロイド / 分子イメージング |
Research Abstract |
Alzheimer's disease (AD) is a neurodegenerative disease of the brain associated with irreversible cognitive decline, memory impairment, and behavioral changes. Postmortem brains of AD patients reveal neuropathologic features : the presence of senile plaques (SPs) and neurofibrillary tangles (NFTs), which contain β-amyloid proteins and highly phosphorylated tau proteins. In the present study, we successfully designed and synthesized several PET/SPECT imaging probes for in vivo detection of SPs and NFTs, and evaluated their utility as molecular imaging probes for SPs and NFTs.
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Report
(4 results)
Research Products
(51 results)