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Genome-wide association study on disease severity of rheumatoid arthritis

Research Project

Project/Area Number 20689029
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionTokyo Women's Medical University

Principal Investigator

IKARI Katsunori  東京女子医科大学, 医学部, 准教授 (80343557)

Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Keywordsリウマチ病学 / 関節リウマチ / 関節破壊 / 遺伝子 / ゲノム / 観閲リウマチ / 重症化
Research Abstract

We tried to investigate independent genetic risk factors for radiographic progression in rheumatoid arthritis(RA) patients. Sharp/van der Heijde score of hands at 5-year disease duration, which represents joint damage, were measured retrospectively and used as an outcome variable in 865 Japanese RA patients. The number of SE alleles and risk alleles of peptidyl arginine deiminase type IV gene had significant impact on progressive joint destruction, as well as following non-genetic factors : higher mean DAS28, ACPA positive, female sex and younger age of onset.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (70 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (56 results) (of which Peer Reviewed: 16 results) Presentation (10 results) Remarks (4 results)

  • [Journal Article] Quantitative effect of HLA-DRB1 alleles to ACPA levels in Japanese rheumatoid arthritis : no strong genetic impact of shared epitope to ACPA levels after stratification of HLA-DRB1 09 : 012012

    • Author(s)
      Terao C, Ikari K, Ohmura K, Suzuki T, Iwamoto T, Takasugi K, Saji H, Taniguchi A, Momohara S, Yamanaka H, Matsuda F, Mimori T
    • Journal Title

      Annals of the rheumatic diseases

      Volume: 71(6) Pages: 1095-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Non-synonymous variant(Gly307Ser) in CD226 is associated with susceptibility in Japanese rheumatoid arthritis patients2012

    • Author(s)
      Suzuki T, Ikari K, Kawaguchi Y, Yano K, Iwamoto T, Kawamoto M, Toyama Y, Taniguchi A, Yamanaka H, Momohara S
    • Journal Title

      Modern rheumatology

      Volume: (in press)

    • NAID

      10031167688

    • Related Report
      2011 Final Research Report
  • [Journal Article] Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population2012

    • Author(s)
      Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K
    • Journal Title

      Nature genetics

      Volume: 44(5) Pages: 511-6

    • Related Report
      2011 Final Research Report
  • [Journal Article] A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese2012

    • Author(s)
      Okada Y, Shimane K, Kochi Y, Tahira T, Suzuki A, Higasa K, Takahashi A, Horita T, Atsumi T, Ishii T, Okamoto A, Fujio K, Hirakata M, Amano H, Kondo Y, Ito S, Takada K, Mimori A, Saito K, Kamachi M, Kawaguchi Y, Ikari K, Mohammed OW, Matsuda K, Terao C, Ohmura K, Myouzen K, Hosono N, Tsunoda T, Nishimoto N, Mimori T, Matsuda F, Tanaka Y, Sumida T, Yamanaka H, Takasaki Y, Koike T, Horiuchi T, Hayashi K, Kubo M, Kamatani N, Yamada R, Nakamura Y, Yamamoto K
    • Journal Title

      PLoS genetics

      Volume: 8(1)

    • NAID

      120005906866

    • Related Report
      2011 Final Research Report
  • [Journal Article] Comparison of characteristics and therapeutic efficacy in rheumatoid arthritis patients treated by rheumatologists and those treated by orthopedic surgeons under a team medicine approach at the same institute2012

    • Author(s)
      Momohara S, Inoue E, Ikari K, Yano K, Tokita A, Honjo Y, Sakuma Y, Hiroshima R, Iwamoto T, Seto Y, Tanaka E, Taniguchi A, Yamanaka H
    • Journal Title

      Modern rheumatology

      Volume: 22(2) Pages: 209-15

    • NAID

      10030615005

    • Related Report
      2011 Final Research Report
  • [Journal Article] Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population2012

    • Author(s)
      Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K.
    • Journal Title

      Nat Genet.

      Volume: (in press) Issue: 5 Pages: 511-6

    • DOI

      10.1038/ng.2231

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative effect of HLA-DRB1 alleles to ACPA levels in Japanese rheumatoid arthritis : no strong genetic impact of shared epitope to ACPA levels after stratification of HLA-DRB1^*09:012012

    • Author(s)
      Terao C, Ikari K, et al
    • Journal Title

      Annals of the rheumatic diseases

      Volume: (e-pub) Issue: 6 Pages: 1095-1097

    • DOI

      10.1136/annrheumdis-2011-200907

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-synonymous variant (Gly307Ser) in CD226 is associated with susce ptibility in Japanese rheumatoid arthritis patients2012

    • Author(s)
      Suzuki T, Ikari K, et al
    • Journal Title

      Modern rheumatology

      Volume: (e-pub) Issue: 1 Pages: 200-202

    • DOI

      10.1007/s10165-012-0609-x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese2012

    • Author(s)
      岡田随象
    • Journal Title

      PLoS Genetics

      Volume: (掲載確定) Issue: 1 Pages: 1002455-1002455

    • DOI

      10.1371/journal.pgen.1002455

    • NAID

      120005906866

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A large-scale association study identified multiple HLA-DRB1 alleles associated with ACPA-negative rheumatoid arthritis in Japanese subjects2011

    • Author(s)
      Terao C, Ohmura K, Kochi Y, Ikari K, Maruya E, Katayama M, Shimada K, Murasawa A, Honjo S, Takasugi K, Matsuo K, Tajima K, Suzuki A, Yamamoto K, Momohara S, Yamanaka H, Yamada R, Saji H, Matsuda F, Mimori T
    • Journal Title

      Annals of the rheumatic diseases

      Volume: 70(12) Pages: 2134-9

    • NAID

      120003796492

    • Related Report
      2011 Final Research Report
  • [Journal Article] Interleukin-18 promoter polymorphisms in Japanese patients with rheumatoid arthritis : protective effect of the T allele and T/T genotype at rs3607222011

    • Author(s)
      Sugiura T, Kawaguchi Y, Ikari K, Ichida H, Kawamoto M, Momohara S, Hara M, Yamanaka H
    • Journal Title

      Modern rheumatology

      Volume: 21(4) Pages: 359-64

    • NAID

      10029512800

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of EMCN with susceptibility to rheumatoid arthritis in a Japanese population2011

    • Author(s)
      Nishimoto K, Ikari K, Kaneko H, Tsukahara S, Kochi Y, Yamamoto K, Nakamura Y, Toyama Y, Taniguchi A, Yamanaka H, Momohara S
    • Journal Title

      The Journal of rheumatology

      Volume: 38(2) Pages: 221-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Recent trends in orthopedic surgery performed in Japan for rheumatoid arthritis2011

    • Author(s)
      Momohara S, Tanaka S, Nakamura H, Mibe J, Iwamoto T, Ikari K, Nishino J, Kadono Y, Yasui T, Takahashi K, Takenouchi K, Hashizume K, Nakahara R, Kubota A, Nakamura T, Nishida K, Suguro T
    • Journal Title

      Modern rheumatology

      Volume: 21(4) Pages: 337-42

    • NAID

      10029512726

    • Related Report
      2011 Final Research Report
  • [Journal Article] Reparative radiological changes of a large joint after adalimumab for rheumatoid arthritis2011

    • Author(s)
      Momohara S, Tanaka E, Iwamoto T, Ikari K, Yamanaka H
    • Journal Title

      Clinical rheumatology

      Volume: 30(4) Pages: 591-2

    • Related Report
      2011 Final Research Report
  • [Journal Article] Prosthetic joint infection after total hip or knee arthroplasty in rheumatoid arthritis patients treated with nonbiologic and biologic disease-modifying antirheumatic drugs2011

    • Author(s)
      Momohara S, Kawakami K, Iwamoto T, Yano K, Sakuma Y, Hiroshima R, Imamura H, Masuda I, Tokita A, Ikari K
    • Journal Title

      Modern rheumatology

      Volume: 21(5) Pages: 469-75

    • NAID

      10030205591

    • Related Report
      2011 Final Research Report
  • [Journal Article] Efficacy of total joint arthroplasty in patients with established rheumatoid arthritis : improved longitudinal effects on disease activity but not on health-related quality of life2011

    • Author(s)
      Momohara S, Inoue E, Ikari K, Yano K, Tokita A, Suzuki T, Sakuma Y, Hiroshima R, Kawakami K, Masuda I, Iwamoto T, Taniguchi A, Yamanaka H
    • Journal Title

      Modern rheumatology

      Volume: 21(5) Pages: 476-81

    • NAID

      10030205622

    • Related Report
      2011 Final Research Report
  • [Journal Article] The increasing disease duration of patients at the time of orthopaedic surgery for rheumatoid arthritis2011

    • Author(s)
      Momohara S, Ikari K, Kawakami K, Iwamoto T, Inoue E, Yano K, Sakuma Y, Hiroshima R, Tokita A, Taniguchi A, Yamanaka H
    • Journal Title

      Rheumatology international

    • Related Report
      2011 Final Research Report
  • [Journal Article] Clinical images : Solitary extranodal malignant lymphoma of the forearm in rheumatoid arthritis2011

    • Author(s)
      Iwamoto T, Seto Y, Ikari K, Yamanaka H, Momohara S
    • Journal Title

      Arthritis and rheumatism

      Volume: 63(1) Pages: 304-304

    • Related Report
      2011 Final Research Report
  • [Journal Article] Pseudotumor from a metal-on-metal hip2011

    • Author(s)
      Iwamoto T, Ikari K, Momohara S
    • Journal Title

      The Journal of rheumatology

      Volume: 38(10) Pages: 2265-2265

    • Related Report
      2011 Final Research Report
  • [Journal Article] Analysis of C-reactive protein levels and febrile tendency after joint surgery in rheumatoid arthritis patients treated with a perioperative 4-week interruption of tocilizumab2011

    • Author(s)
      Hiroshima R, Kawakami K, Iwamoto T, Tokita A, Yano K, Sakuma Y, Ikari K, Momohara S
    • Journal Title

      Modern rheumatology

      Volume: 21(1) Pages: 109-11

    • NAID

      10029361543

    • Related Report
      2011 Final Research Report
  • [Journal Article] A large-scale association study identified multiple HLA-DRB1 alleles associated with ACPA-negative rheumatoid arthritis in Japanese subjects2011

    • Author(s)
      Terao C, Ohmura K, Kochi Y, Ikari K, et al
    • Journal Title

      Annals of the rheumatic diseases

      Volume: 70 Issue: 12 Pages: 2134-9

    • DOI

      10.1136/annrheumdis-2011-200353

    • NAID

      120003796492

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population.2011

    • Author(s)
      Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, Okamoto A, Yamada R, Myouzen K, Suzuki A, Kubo M, Atsumi T, Koike T, Takasaki Y, Momohara S, Yamanaka H, Nakamura Y, Yamamoto K.
    • Journal Title

      Arthritis Rheum. 62(2)

      Pages: 574-579

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese.2011

    • Author(s)
      Nishimoto K, Kochi Y, Ikari K, Yamamoto K, Suzuki A, Shimane K, Nakamura Y, Yano K, Iikuni N, Tsukahara S, Kamatani N, Okamoto H, Kaneko H, Kawaguchi Y, Hara M, Toyama Y, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Yamanaka H, Momohara S
    • Journal Title

      Ann Rheum Dis 69(2)

      Pages: 368-373

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Association of EMCN with susceptibility to rheumatoid arthritis in a Japanese population2011

    • Author(s)
      Nishimoto K, et al
    • Journal Title

      J Rheumatol

      Volume: 38 Pages: 221-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-18 promoter polymorphisms in Japanese patients with rheumatoid arthritis : protective effect of the T allele and T/T genotype at rs3607222011

    • Author(s)
      Sugiura T, et al.
    • Journal Title

      Mod Rheumatol

      Volume: (e-pub)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of total knee arthroplasty on disease activity in patients with established rheumatoid arthritis : 3-year follow-up results of combined medical therapy and surgical intervention2010

    • Author(s)
      Yano K, Ikari K, Inoue E, Tokita A, Sakuma Y, Hiroshima R, Iwamoto T, Kawakami K, Taniguchi A, Yamanaka H, Momohara S
    • Journal Title

      Modern rheumatology

      Volume: 20(5) Pages: 452-7

    • NAID

      10027646979

    • Related Report
      2011 Final Research Report
  • [Journal Article] The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population2010

    • Author(s)
      Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, Okamoto A, Yamada R, Myouzen K, Suzuki A, Kubo M, Atsumi T, Koike T, Takasaki Y, Momohara S, Yamanaka H, Nakamura Y, Yamamoto K
    • Journal Title

      Arthritis and rheumatism

      Volume: 62(2) Pages: 574-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Reparative radiological changes of the hip joint in rheumatoid arthritis : do these findings indicate the true repair of the joint2010

    • Author(s)
      Sakuma Y, Ikari K, Iwamoto T, Tokita A, Momohara S
    • Journal Title

      Joint, bone, spine : revue du rhumatisme.

      Volume: 77(3) Pages: 278-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Single nucleotide polymorphisms of CD244 gene predispose to renal and neuropsychiatric manifestations with systemic lupus erythematosus2010

    • Author(s)
      Ota Y, Kawaguchi Y, Takagi K, Tochimoto A, Kawamoto M, Katsumata Y, Gono T, Masuda I, Ikari K, Momohara S, Yamanaka H
    • Journal Title

      Modern rheumatology

      Volume: 20(5) Pages: 427-31

    • NAID

      10027646881

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese2010

    • Author(s)
      Nishimoto K, Kochi Y, Ikari K, Yamamoto K, Suzuki A, Shimane K, Nakamura Y, Yano K, Iikuni N, Tsukahara S, Kamatani N, Okamoto H, Kaneko H, Kawaguchi Y, Hara M, Toyama Y, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Yamanaka H, Momohara S
    • Journal Title

      Annals of the rheumatic diseases

      Volume: 69(2) Pages: 368-73

    • Related Report
      2011 Final Research Report
  • [Journal Article] Decrease in orthopaedic operations, including total joint replacements, in patients with rheumatoid arthritis between 2001 and 2007 : data from Japanese outpatients in a single institute-based large observational cohort(IORRA)2010

    • Author(s)
      Momohara S, Inoue E, Ikari K, Kawamura K, Tsukahara S, Iwamoto T, Hara M, Taniguchi A, Yamanaka H
    • Journal Title

      Annals of the rheumatic diseases

      Volume: 69(1) Pages: 312-3

    • Related Report
      2011 Final Research Report
  • [Journal Article] A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility2010

    • Author(s)
      Kochi Y, Okada Y, Suzuki A, Ikari K, Terao C, Takahashi A, Yamazaki K, Hosono N, Myouzen K, Tsunoda T, Kamatani N, Furuichi T, Ikegawa S, Ohmura K, Mimori T, Matsuda F, Iwamoto T, Momohara S, Yamanaka H, Yamada R, Kubo M, Nakamura Y, Yamamoto K
    • Journal Title

      Nature genetics

      Volume: 42(6) Pages: 515-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Complications and features after joint surgery in rheumatoid arthritis patients treated with tumour necrosis factor-alpha blockers : perioperative interruption of tumour necrosis factor-alpha blockers decreases complications2010

    • Author(s)
      Kawakami K, Ikari K, Kawamura K, Tsukahara S, Iwamoto T, Yano K, Sakuma Y, Tokita A, Momohara S
    • Journal Title

      Rheumatology(Oxford)

      Volume: 49(2) Pages: 341-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Multiple extensor tendon ruptures caused by tophaceous gout2010

    • Author(s)
      Iwamoto T, Toki H, Ikari K, Yamanaka H, Momohara S
    • Journal Title

      Modern rheumatology

      Volume: 20(2) Pages: 210-2

    • NAID

      10027169126

    • Related Report
      2011 Final Research Report
  • [Journal Article] A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.2010

    • Author(s)
      Kochi Y, Okada Y, Suzuki A, Ikari K, Terao C, Takahashi A, Yamazaki K, Hosono N, Myouzen K, Tsunoda T, Kamatani N, Furuichi T, Ikegawa S, Ohmura K, Mimori T, Matsuda F, Iwamoto T, Momohara S, Yamanaka H, Yamada R, Kubo M, Nakamura Y, Yamamoto K.
    • Journal Title

      Nat Genet. 42(6)

      Pages: 515-519

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility2010

    • Author(s)
      Kochi Y, et al.
    • Journal Title

      Nat Genet

      Volume: 42 Pages: 515-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese2010

    • Author(s)
      Nishimoto K., et al.
    • Journal Title

      Ann Rheum Dis.69(2):368-73. 69

      Pages: 368-73

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population.2010

    • Author(s)
      Shimane S., et el.
    • Journal Title

      Arthritis Rheum 62

      Pages: 574-9

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A thought on postgraduate psychiatric education from the viewpoint of residents in the latter stage of training based on the system of training of psychiatric specialists-the latter part of the psychiatric training at university hospitals2009

    • Author(s)
      Nakano W, Kato T, Tateno M, Ikari K, Tanaka T, Nakamae T, Hojusan T, Nakamura J
    • Journal Title

      Seishin shinkeigaku zasshi=Psychiatria et neurologia Japonica

      Volume: 111(10) Pages: 1214-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Declining use of synovectomy surgery for patients with rheumatoid arthritis in Japan2009

    • Author(s)
      Momohara S, Ikari K, Mochizuki T, Kawamura K, Tsukahara S, Toki H, Hara M, Kamatani N, Yamanaka H, Tomatsu T
    • Journal Title

      Annals of the rheumatic diseases

      Volume: 68(2) Pages: 291-2

    • Related Report
      2011 Final Research Report
  • [Journal Article] Clinical image : adductor muscle strain in an elderly patient with suspected femoral neck fracture2009

    • Author(s)
      Kawakami K, Ikari K, Yano K, Momohara S
    • Journal Title

      Arthritis and rheumatism

      Volume: 60(11) Pages: 3446-3446

    • Related Report
      2011 Final Research Report
  • [Journal Article] A1330V polymorphism of low-density lipoprotein receptor-related protein 5 gene and self-reported incident fractures in Japanese female patients with rheumatoid arthritis2009

    • Author(s)
      Furuya T, Urano T, Ikari K, Kotake S, Inoue S, Hara M, Momohara S, Kamatani N, Yamanaka H
    • Journal Title

      Modern rheumatology

      Volume: 19(2) Pages: 140-6

    • NAID

      10025112411

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effect of matrix metalloproteinase-3 functional SNP on serum matrix metalloproteinase-3 level and outcome measures in Japanese RA patients2008

    • Author(s)
      Tsukahara S, Shinozaki M, Ikari K, Mochizuki T, Inoue E, Tomatsu T, Hara M, Yamanaka H, Kamatani N, Momohara S
    • Journal Title

      Rheumatology(Oxford)

      Volume: 47(1) Pages: 41-4

    • Related Report
      2011 Final Research Report
  • [Journal Article] CTLA-4 CT60 polymorphism is not an independent genetic risk marker of rheumatoid arthritis in a Japanese population2008

    • Author(s)
      Tsukahara S, Iwamoto T, Ikari K, Inoue E, Tomatsu T, Hara M, Yamanaka H, Kamatani N, Momohara S
    • Journal Title

      Annals of the rheumatic diseases

      Volume: 67(3) Pages: 428-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] A polymorphism in the gene encoding the Fcgamma IIIA receptor is a possible genetic marker to predict the primary response to infliximab in Japanese patients with rheumatoid arthritis2008

    • Author(s)
      Tsukahara S, Ikari K, Sato E, Yamanaka H, Hara M, Tomatsu T, Momohara S, Kamatani N
    • Journal Title

      Annals of the rheumatic diseases

      Volume: 67(12) Pages: 1791-2

    • Related Report
      2011 Final Research Report
  • [Journal Article] Iliopsoas bursitis-associated femoral neuropathy exacerbated after internal fixation of an intertrochanteric hip fracture in rheumatoid arthritis : a case report2008

    • Author(s)
      Tokita A, Ikari K, Tsukahara S, Toki H, Miyawaki M, Mochizuki T, Kawamura K, Tomatsu T, Momohara S
    • Journal Title

      Modern rheumatology

      Volume: 18(4) Pages: 394-8

    • NAID

      10021947039

    • Related Report
      2011 Final Research Report
  • [Journal Article] Infusion reaction to infliximab in a patient with rheumatoid arthritis after discontinuation over 1 year and readministration2008

    • Author(s)
      Toki H, Momohara S, Tsukahara S, Ikari K
    • Journal Title

      The Journal of rheumatology

      Volume: 35(9) Pages: 1896-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Return of infliximab efficacy after total knee arthroplasty in a patient with rheumatoid arthritis2008

    • Author(s)
      Toki H, Momohara S, Ikari K, Kawamura K, Tsukahara S, Mochizuki T, Sato E, Yamanaka H
    • Journal Title

      Clinical rheumatology

      Volume: 27(4) Pages: 549-50

    • Related Report
      2011 Final Research Report
  • [Journal Article] Retrospective clinical study on the notable efficacy and related factors of infliximab therapy in a rheumatoid arthritis management group in Japan : one-year outcome of joint destruction(RECONFIRM-2J)2008

    • Author(s)
      Takeuchi T, Yamanaka H, Inoue E, Nagasawa H, Nawata M, Ikari K, Saito K, Sekiguchi N, Sato E, Kameda H, Iwata S, Mochizuki T, Amano K, Tanaka Y.
    • Journal Title

      Modern rheumatology

      Volume: 18(5) Pages: 447-54

    • NAID

      10024374129

    • Related Report
      2011 Final Research Report
  • [Journal Article] Lack of association between PADI4 and functional severity in Japanese rheumatoid arthritis patients2008

    • Author(s)
      Nishimoto K, Ikari K, Mochizuki T, Tomatsu T, Toyama Y, Hara M, Yamanaka H, Kamatani N, Momohara S
    • Journal Title

      Annals of the rheumatic diseases

      Volume: 67(3) Pages: 431-2

    • Related Report
      2011 Final Research Report
  • [Journal Article] Risk factors for wrist surgery in rheumatoid arthritis2008

    • Author(s)
      Momohara S, Inoue E, Ikari K, Tsukahara S, Kawamura K, Toki H, Hara M, Kamatani N, Yamanaka H, Tomatsu T
    • Journal Title

      Clinical rheumatology

      Volume: 27(11) Pages: 1387-91

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population2008

    • Author(s)
      Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, Nakamura Y, Toyama Y, Mochizuki T, Tsukahara S, Kawaguchi Y, Terai C, Hara M, Tomatsu T, Yamanaka H, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Okamoto H, Kamatani N, Momohara S
    • Journal Title

      Arthritis and rheumatism

      Volume: 58(7) Pages: 1940-6

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of the MSX2 gene polymorphisms with ankylosing spondylitis in Japanese2008

    • Author(s)
      Furuichi T, Maeda K, Chou CT, Liu YF, Liu TC, Miyamoto Y, Takahashi A, Mori K, Ikari K, Kamatani N, Kurosawa H, Inoue H, Tsai SF, Ikegawa S
    • Journal Title

      Journal of human genetics

      Volume: 53(5) Pages: 419-24

    • NAID

      10021248849

    • Related Report
      2011 Final Research Report
  • [Journal Article] Lack of association between PADI4 and functional severity in Japanese rheumatoid arthritis patients.2008

    • Author(s)
      Nishimoto K, Ikari K, Mochizuki T, Tomatsu T, Toyama Y, Hara M, Yamanaka H, Kamatani N, Momohara S.
    • Journal Title

      Ann Rheum Dis. 67(3)

      Pages: 431-432

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population.2008

    • Author(s)
      Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, Nakamura Y, Toyama Y, Mochizuki T, Tsukahara S, Kawaguchi Y, Terai C, Hara M, Tomatsu T, Yamanaka H, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Okamoto H, Kamatani N, Momohara S
    • Journal Title

      .Arthritis Rheum. 58(7)

      Pages: 1940-1946

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Association study of TRAF1-05 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese

    • Author(s)
      K. Nishimoto, et.al.
    • Journal Title

      Annals of the Rheumatic Diseases (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] GENOME WIDE ASSOCIATION STUDY IDENTIFIE ABCA1/SLC44A1 AS RISK LOCI FOR THE JOINT DESTRUCTION IN JAPANESE RAPATIENTS2011

    • Author(s)
      Taku S, Ikari K, et al
    • Organizer
      欧州リウマチ会議(EULAR)
    • Place of Presentation
      ロンドン、イギリス
    • Year and Date
      2011-05-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] TNIP2 is associated with joint destruction in patients with rheumatoid arthritis2010

    • Author(s)
      Suzuki T, et al.
    • Organizer
      American College of Rheumatology
    • Place of Presentation
      Atlanta, U.S.A.
    • Year and Date
      2010-11-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] IMPACT OF HLA-DRB1 AND NON-HLA GENETIC EACTORS ON DIS EASE SUSCEPTIBILITY AND RADIOGRAPHIC JOINT DAMAGE IN JAPANESE RHEUMATOID ARTHRITIS PATIENTS2009

    • Author(s)
      Ikari K., et al.
    • Organizer
      欧州リウマチ会議(EULAR)
    • Place of Presentation
      デンマーク、コペンハーゲン
    • Related Report
      2009 Annual Research Report
  • [Presentation] CD40 IS ASSOCIATED WITH RA IN JAPANESE2009

    • Author(s)
      Tokita A., et al.
    • Organizer
      欧州リウマチ会議(EULAR)
    • Place of Presentation
      デンマーク、コペンハーゲン
    • Related Report
      2009 Annual Research Report
  • [Presentation] Interleukin 2 receptor-alpha is associated with radiographic joint damage in a Japanese RA population.2009

    • Author(s)
      Suzuki T., et al.
    • Organizer
      米国リウマチ学会(ACR)
    • Place of Presentation
      フィラデルフィア、米国
    • Related Report
      2009 Annual Research Report
  • [Presentation] Failure to confirm association of three polymorphisms of rheumatoidarthritis susceptibility identified by the Wellcome Trust Case Control Consortium in a Japanese population2009

    • Author(s)
      Suzuki T., et al.
    • Organizer
      米国人類遺伝学会(ASHG)
    • Place of Presentation
      ホノルル、米国
    • Related Report
      2009 Annual Research Report
  • [Presentation] 関節リウマチにおけるHLA及びnon-HLA疾患感受性遺伝子と関節破壊との関連2009

    • Author(s)
      猪狩勝則
    • Organizer
      日本整形外科学会基礎集会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rephcation study fbr the Wellcome Trust Case Control Consortium datain large-scaled Japanese rheumatoid arthritis case-control populations2008

    • Author(s)
      S. Tsukahara, et.al.
    • Organizer
      米国人類遺伝学会(ASHG)
    • Place of Presentation
      フィラデルフィア、アメリカ
    • Year and Date
      2008-11-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] ASSOCIATION OF A POLYMORPHISM ON 6Q23 WITH RHEUMATOI D ARTHRITIS IN A JAPANESE POPULATION2008

    • Author(s)
      S. Tsukahara, et.al.
    • Organizer
      欧州リウマチ会議(EULAR)
    • Place of Presentation
      パリ、フランス
    • Year and Date
      2008-06-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] STAT4 IS ASSOCLATED WITH RA AND I.UPUS IN JAPANESE2008

    • Author(s)
      K Ikari, et.al.
    • Organizer
      欧州リウマチ会議(EULAR)
    • Place of Presentation
      パリ、ランス
    • Year and Date
      2008-06-12
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.twmu.ac.jp/IOR/JointSurgery/

    • Related Report
      2011 Final Research Report
  • [Remarks] ホームページアドレス

    • URL

      http://www.twmu.ac.jp/IOR

    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.twmu.ac.jp/IOR/JointSurgery/achievement.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.twmu.ac.jp/IOR/JointSurgery/

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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