Neuropathic pain-related molecules regulated by P2X4R in microglia
| Project/Area Number |
20689030
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyushu University |
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Principal Investigator |
TSUDA Makoto Kyushu University, 薬学研究院, 准教授 (40373394)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2009: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2008: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 疼痛管理学 / P2X4受容体 / 神経障害性疼痛 / ミクログリア / 脊髄後角 / アロディニア / ケモカイン / 神経因性疼痛 |
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| Research Abstract |
The aim of the present study was to identify microglial genes whose expression are regulated by P2X4Rs, a receptor crucial for neuropathic pain, and to investigate the role of these molecules in neuropathic pain. The present study found P2Y12 receptor and chemokines as the candidate genes. We also showed an important role of P2Y12 receptor in neuropathic pain and a new mechanism for P2X4R trafficking to the plasma membrane through the chemokine receptor CCR2. Thus, it is possible that targeting P2X4R-regulating genes and P2X4 trafficking may be new therapeutic strategy for treating neuropathic pain.
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Report
(4 results)
Research Products
(89 results)
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[Journal Article] JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats.2011
Author(s)
Tsuda M, Kohro Y, Yano T, Tsujikawa T, Kitano J, Tozaki-Saitoh H, Koyanagi S, Ohdo S, Ji RR, Salter MW, Inoue K
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Journal Title
Brain 134
Pages: 1127-1139
NAID
Related Report
Peer Reviewed
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