| Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2009: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2008: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
|
|---|
| Research Abstract |
The aim of the present study was to identify microglial genes whose expression are regulated by P2X4Rs, a receptor crucial for neuropathic pain, and to investigate the role of these molecules in neuropathic pain. The present study found P2Y12 receptor and chemokines as the candidate genes. We also showed an important role of P2Y12 receptor in neuropathic pain and a new mechanism for P2X4R trafficking to the plasma membrane through the chemokine receptor CCR2. Thus, it is possible that targeting P2X4R-regulating genes and P2X4 trafficking may be new therapeutic strategy for treating neuropathic pain.
|
