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Predicting enzyme functions based on complementarily in molecular interactions by using radial distribution functions with a self-organizing maps

Research Project

Project/Area Number 20700263
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Bioinformatics/Life informatics
Research InstitutionHokkaido University

Principal Investigator

UENO Keisuke  Hokkaido University, 大学院・情報科学研究科, 博士研究員 (90435983)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords酵素機能予測 / 動径分布関数 / 自己組織化写像 / 分子間相互作用
Research Abstract

We developed a method to predict enzyme functions by using radial distribution functions of active sites with a self-organizing map. The method outperformed the structural and sequence alignments with their low similarities.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report

Research Products

(6 results)

All 2009 2008

All Presentation (6 results)

  • [Presentation] Enzyme function classified with a catalytic-site similarity2009

    • Author(s)
      上野惠介
    • Organizer
      CBI学会2009年大会(CBI-KSBSB JOINT CONFERENCE)
    • Place of Presentation
      韓国(海雲台グランドホテル)
    • Year and Date
      2009-11-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Enzyme function classified with a catalytic-site similarity2009

    • Author(s)
      上野恵介
    • Organizer
      CBI学会2009年大会(CBI-KSBSB JOINT CONFERENCE)
    • Place of Presentation
      海雲台グランドホテル, 釜山, 韓国
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Physicochemical Property of Enzyme-Ligand Interface for Molecular Interaction2008

    • Author(s)
      上野惠介
    • Organizer
      2008年日本バイオインフオマテイクス学会年会
    • Place of Presentation
      大阪(千里ライフサイエンスセンタービル)
    • Year and Date
      2008-12-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Physicochemical Property of Enzyme-Ligand Interface for Molecular Interaction2008

    • Author(s)
      上野恵介
    • Organizer
      2008年日本バイオインフォマティクス学会年会
    • Place of Presentation
      千里ライフサイエンスセンタービル、大阪
    • Year and Date
      2008-12-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Landscaping Enzymatic Reactions of Oxidoreductases by a Self-Organizing Neural Network2008

    • Author(s)
      上野惠介
    • Organizer
      第17回国際タンパク質化学構造解析会議
    • Place of Presentation
      札幌(北海道大学学術交流会館)
    • Year and Date
      2008-08-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Landscaping Enzymatic Reactions of Oxidoreductases by a Self-Organizing Neural Network2008

    • Author(s)
      上野恵介
    • Organizer
      第17回国際タンパク質化学構造解析会議
    • Place of Presentation
      北海道大学学術交流会館、札幌
    • Year and Date
      2008-08-28
    • Related Report
      2008 Annual Research Report

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Published: 2008-03-31   Modified: 2016-04-21  

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