| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
A question how cellular phenotype changes by genetic modifications is important for rational design of desired microorganisms for industrial purpose. Here, we comprehensively analyzed the phynotypic changes of yeast strains in single gene deletion library and single gene overexpression library. Based on the data, we found gene functional categories which are robust or fragile for the gene perturbations, and we also analyzed the correlation between expression changes and response to the gene perturbations.
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