Design and construction of genetic relaxation oscillators based on systems and synthetic biology.

Research Project

Project/Area Number	20700271
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Bioinformatics/Life informatics
Research Institution	Keio University
Principal Investigator	YUGI Katsuyuki Keio University, 大学院・理学系研究科, 特任助教 (70433745)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	生体生命システム情報学 / 構成的生物学 / システム生物学 / 合成生物学 / イメージング / 人工遺伝子回路 / 反応速度論 / 振動子 / 非線形力学系 / 分子拡散 / 1細胞イメージング / 定量測定 / 転写調節因子 / プロモータ7 / 反応速度式 / 二色蛍光
Research Abstract	Design and measurement methods for rational design of artificial genetic networks were developed toward constructing genetic relaxation oscillators. The measurement methods are employed for quantification of kinetic parameters of "genetic parts" composing the genetic circuits. Integration of these measurement methods and in silico model enables rational design of artificial genetic circuits.

Report

(4 results)