| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Dynamic models of signal transduction involve a combinatorial explosion problem in their kinetic parameters modeled. A methodology proposed was a kind of static modeling. An algebraic method showed a reaction participation and pathway ength of extreme pathways which span the kernel of the stoichiometric matrix. Also, a discrete analysis revealed the distribution of k-shortest pathways of a weighted, directed graph. These calculations were possible alternatives for a schematic representation of signal transduction.
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