Molecular mechanisms of establishment of brain asymmetry
Project/Area Number |
20700281
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Neuroscience in general
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Research Institution | Tohoku University |
Principal Investigator |
MASANORI Takahashi Tohoku University, 大学院・医学系研究科, 助教 (20361074)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 分子・細胞神経科学 / 左右非対称性 / カドヘリン / 大脳皮質 / 線条体 / 活動依存性 |
Research Abstract |
In this study, I examined characters of cells expressing cadherin20 in the lateral striatal region and somatosensory cortex in adult rats using in situ hybridization and immunohistochemistry. These studies revealed that all cadherin20+ cells in the lateral striatum were both direct and indirect pathways medium spiny projection neurons. I also established the method to determine relationship between asymmetric expression of cadherin20 and handedness in rats. We could distinguish left or right-handedness of rats using this method.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Downstream genes of Pax6 revealed by comprehensive transcriptome profiling in the developing rat hindbrain.2010
Author(s)
Numayama-Tsuruta, K., Arai, Y., Takahashi, M., Sasaki-Hoshino, M., Funatsu, N., Nakamura, S., Osumi, N.
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Journal Title
BMC Dev. Biol. 10
Pages: 6-6
Related Report
Peer Reviewed
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[Journal Article] Downstream genes of Pax6 revealed by comprehensive transcriptome profiling in the developing rat hindbrain2010
Author(s)
Numayama-Tsuruta, K., Arai, Y., Takahashi, M., Sasaki-Hoshino, M., Funatsu,N., Nakamura, S., Osumi, N.
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Journal Title
BMC Dev.Biol. 10
Pages: 6-6
Related Report
Peer Reviewed
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