| Project/Area Number |
20700287
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Nagoya City University |
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Principal Investigator |
UEKI Yoshino Nagoya City University, 大学院・医学研究科, 臨床研究医 (40467478)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ドパミン / 脳可塑性 / パーキンソン病 / 運動学習 / 脳機能イメージング |
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| Research Abstract |
In patients with Parkinson's disease, its depletion might cause impairment of higher motor function including motor skill learning. To elucidate whether striatal domapine release is associated with the acquisition of new motor skill, we investigated changes in striatal dopamine levels using a maker of D2/D3-receptor binding with 11C-raclopride PET. We revealed that striatal dopamine plays an essential role for the acquisition of new motor skill, which may reflect the dynamic modulation to basal ganglia-motor cortical circuit.
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