Neuronal activity in the thalamic CM and striatum during response bias and its complementary process

• Project/Area Number: 20700293
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: HORI Yukiko Kyoto Prefectural University of Medicine, 分子イメージング研究センター, 博士研究員 (30433246)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 視床 / 大脳基底核 / 報酬 / 行動神経科学 / 神経細胞外記録

Research Abstract

We examined how the thamalo-striatal system involves the process of selection with the undesirable action when the monkeys biased the desirable action. Striatum neurons encoded response bias and specific action combined with reward size before and after instruction epoch. The thalamic CM neurons were related to cancellation of response bias when the monkeys required the undesirable action. Thus, the thamalo-striatal system might involve in biasing toward action based on the reward value and cancellation when unexpected situation was occurred.

Research Products

• [Journal Article] Neuronal encoding of reward value and direction of actions in the primate putamen (2009)
  • Author(s): Hori Y, Minamimoto T, Kimura M.
  • Journal Title: Journal of Neurophysiology. 102 Pages: 3530-3543
  • Peer Reviewed
• [Journal Article] Roles of the thalamic CM-PF complex-Basal ganglia circuit in externally driven rebias of action (2009)
  • Author(s): Minamimoto T, Hori Y, Kimura M.
  • Journal Title: Brain Res Bulletin. 78 Pages: 75-79
  • Peer Reviewed
• [Journal Article] Roles of the thalamic CM-PF complex-Basal ganglia circuit in externally driven rebias of action. (2009)
  • Author(s): Minamimoto T, Hori Y, Kimura M.
  • Journal Title: Brain Res Bulletin. 78 Pages: 75-79
  • Peer Reviewed
• [Journal Article] Roles of the thalamic CM-PF complex-Basal ganglia circuit in externally driven rebias of action (2009)
  • Author(s): Minamimoto T, Hori Y. & Kimura M
  • Journal Title: Brain Research Bulletin 78 Pages: 75-79
  • Peer Reviewed
• [Presentation] Activity of neurons in the thalamic centromedian nucleus during behavioral tasks with reward bias and re-bias (2010)
  • Author(s): Ko Yamanaka, Yukiko Hori, Yasumasa Ueda, Takafumi Minamimoto, Minoru Kimura
  • Organizer: NEUROSCIENCE2010
  • Place of Presentation: SAN DIEGO (USA)
  • Year and Date: 2010-11-15
• [Presentation] Neural coding of predicted and experienced outcome value with temporal discounting in the primate caudate nucleus (2010)
  • Author(s): Yukiko Hori, Barry J.Richmond, Takafumi Minamimoto
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2010-09-03
• [Presentation] Activity of neurons in the thalamic centromedian nucleus during behavioral tasks with reward bias and re-bias. (2010)
  • Author(s): Yamanaka K, Hori Y, Ueda Y, Minamimoto T, Kimura M.
  • Organizer: So Neursci Abstr 511.6
• [Presentation] Neural coding of predicted and experienced outcome value with temporal discounting in the primate caudate nucleus. (2010)
  • Author(s): Hori Y, Richmond BJ, Minamimoto T.
  • Organizer: Neurosci Res Supple, 68, e295
• [Presentation] Signals of reward value and actions represented in the neuronal activity of CM thalamus. (2010)
  • Author(s): Yamanaka K, Hori Y, Ueda Y, Minamimoto T, Kimura M.
  • Organizer: 68, e293
• [Presentation] Neuronal activity of CM thalamus during reward-bias task of monkey. (2009)
  • Author(s): Ko Yamanaka, Yukiko Hori, Yasumasa Ueda, Minoru Kimura
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-09-16
• [Presentation] Neuronal activity of CM thalamus during reward-bias task of monkey. (2009)
  • Author(s): Yamanaka K, Hori Y, Ueda Y, Kimura M.
  • Organizer: Neurosci Res Supple, 65, S106
• [Remarks]
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/19812294?itoo1=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1