Molecular mechanisms based on the regional specificity of olfactory sensory neurons.

• Project/Area Number: 20700294
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Nara Medical University
• Principal Investigator: TAKAHASHI Hiroo Nara Medical University, 医学部, 助教 (20390685)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 嗅細胞 / 分化 / 領域特異性 / Pax6 / BMPシグナル

Research Abstract

Olfactory sensory neurons (OSNs) expressing a given odorant receptor project axons to a pair of fixed glomeruli on the olfactory bulb to form a topographic map. In this study, we revealed that some BMP family members are variously expressed in olfactory epithelium (OE) during development. BMP7 and Pax6 are specifically expressed in a unique subset of OSNs, termed Car2 OSNs, which exists in the ventro-lateral region of the OE and is known to respond to CO_2 We found that Pax6 regulates the establishment of the signaling cascade of Car2 OSNs.

Research Products

• [Journal Article] Neuropilin-2 is required for the proper targeting of ventral glomeruli in the mouse olfactory bulb (2010)
  • Author(s): Takahashi H., Yoshihara S., Nishizumi H., Tsuboi A.
  • Journal Title: Molecular and Cellular Neuroscience 44 Pages: 233-245
  • Peer Reviewed
• [Journal Article] Neuropilin-2 is required for the proper targeting of ventral glomeruli in the mouseolfactory bulb.
  • Author(s): Takahashi, et al
  • Journal Title: Molecular and Cellular Neuroscience オンライン
  • Peer Reviewed
• [Presentation] マウス嗅覚系におけるCO2センサー細胞の解析 (2009)
  • Author(s): 高橋弘雄
  • Organizer: 第32回日本分子生物学会念
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] マウス嗅覚系におけるCO_2センサー細胞の解析 (2009)
  • Author(s): 高橋弘雄
  • Organizer: 第32回日本分子生物学会念会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] Molecular basis of CO2 sensing in the mouse olfactory system (2009)
  • Author(s): 高橋弘雄
  • Organizer: Neuroscience 2009
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-09-18
• [Presentation] Molecular basis of CO_2 sensing in the mouse olfactory system. (2009)
  • Author(s): 高橋弘雄
  • Organizer: Neuroscience 2009
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-09-18
• [Presentation] Molecular mechanisms underlying formation of the Odor map in the mouse brain (2009)
  • Author(s): 高橋弘雄
  • Organizer: KEYSTONE SYMPOSIA
  • Place of Presentation: Keystone, Colorado
  • Year and Date: 2009-02-20
• [Presentation] マウス匂い地図形成の分子機構 (2008)
  • Author(s): 高橋弘雄
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-10