Molecular mechanisms based on the regional specificity of olfactory sensory neurons.
| Project/Area Number |
20700294
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Nara Medical University |
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Principal Investigator |
TAKAHASHI Hiroo Nara Medical University, 医学部, 助教 (20390685)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 嗅細胞 / 分化 / 領域特異性 / Pax6 / BMPシグナル |
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| Research Abstract |
Olfactory sensory neurons (OSNs) expressing a given odorant receptor project axons to a pair of fixed glomeruli on the olfactory bulb to form a topographic map. In this study, we revealed that some BMP family members are variously expressed in olfactory epithelium (OE) during development. BMP7 and Pax6 are specifically expressed in a unique subset of OSNs, termed Car2 OSNs, which exists in the ventro-lateral region of the OE and is known to respond to CO_2 We found that Pax6 regulates the establishment of the signaling cascade of Car2 OSNs.
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Report
(3 results)
Research Products
(8 results)
