| Project/Area Number |
20700295
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Keio University |
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Principal Investigator |
IIJIMA Takatoshi Keio University, 医学部, 助教 (90383702)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | C1q / brain / Mouse / cytokine / Cbln / hippocampus / inferior olive / 小脳 / シナプス形成 / Clq / シナプス可塑性 / サイトカイン / TNF-aスーパーファミリー |
|---|
| Research Abstract |
C1q family, which is characterized by the C-terminal globular C1q (gC1q) domain, plays important roles in various intercellular processes. In addition, some of the C1q family members are expressed in the central nervous system. There are increasing evidences for the biological significance of C1q family in neurons. Nevertheless, their functions of C1q family proteins in CNS still remain unclear. Here we characterized C1q-like (C1ql) protein subfamily. These results indicate that, like Cbln subfamily, C1ql subfamily members may serve as a neuronal cytokine for synaptic functions in various brain regions.
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