Dendrite targeting mechanism in neurons.

• Project/Area Number: 20700296
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Keio University
• Principal Investigator: MATSUDA Shinji Keio University, 医学部, 講師 (60321816)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 神経細胞 / 極性輸送 / AMPA受容体 / TARPアダプタータンパク質 / エンドサイトーシス / シナプス可塑性 / TARP / Adaptor Protein Complex / 樹上突起 / タンパク質輪送 / AP-4 / mLin-7 / Yeast Two hybrid / 長期抑圧 / アダプタータンパク / 細胞内輸送

Research Abstract

We indicated that the AP-4 deficient mice, which induces AMPA receptor mislocalization, showed abnormalities on the motor learning and anxiety behavior. Our electrophysiological analysis also indicated that the cerebellar LTP was impaired.
We also indicated that the AMPA receptors bind to AP-2 and AP-3A via TARP. These interactions are regulated by the phosphorylation of TARPs.

Research Products

• [Journal Article] Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synapses in the cerebellum (2009)
  • Author(s): Matsuda K, Kondo T, Iijima T, Matsuda S, Watanabe M, Yuzaki M
  • Journal Title: EUROPEAN JOURNAL OF NEUROSCIENCE 29 Pages: 707-717
  • Peer Reviewed
• [Journal Article] Polarized sorting of AMPA receptors to the somatodendritic domain is regulated by adaptor protein AP-4 (2009)
  • Author(s): Matsuda S, Yuzaki M
  • Journal Title: NEUROSCIENCE RESEARCH 65 Pages: 1-5
  • NAID: 10027499929
  • Peer Reviewed
• [Journal Article] Polarized sorting of AMPA receptors to the somatodendritic domain is regulated by adaptor protein AP-4 (2009)
  • Author(s): Shinji Matsuda, Michisuke Yuzaki
  • Journal Title: Neuroscience Research 65 Pages: 1-5
  • NAID: 10027499929
  • Peer Reviewed
• [Journal Article] Accumulation of AMPA receptor in autophagosomes in neuronal axons lacking adaptor protein AP-4. (2008)
  • Author(s): Matsuda, S., Miura, E., Matsuda, K., Kakegawa, W., Kohda, K., Watanabe, M., Yuzaki, M.
  • Journal Title: Neuron 57 Pages: 730-745
  • Peer Reviewed
• [Journal Article] AP-4: autophagy-four mislocalized proteins in axons (2008)
  • Author(s): Matsuda S, Yuzaki M
  • Journal Title: Autophagy 4 Pages: 815-816
• [Journal Article] 神経における極性輸送 (2008)
  • Author(s): 松田信爾、柚崎通介
  • Journal Title: 蛋白質核酸酵素 53 Pages: 2214-2219
• [Journal Article] AP-4 : Autophagy-four mislocalized proteins in axons (2008)
  • Author(s): Matsuda, S., Yuzaki, M
  • Journal Title: Autophagy 4 Pages: 815-816
  • Peer Reviewed
• [Journal Article] 神経における極性輸送-ついに樹状突起特異的輸送の分子機構の-端が明らかに (2008)
  • Author(s): 松田信爾、柚崎通介
  • Journal Title: 蛋白質核酸酵素 53 Pages: 2214-2219
• [Presentation] New mechanisms regulating the number of AMPA receptors at synapses (2009)
  • Author(s): Michisuke Yuzaki, Shinji Matsuda柚崎通介、松田信爾
  • Organizer: 第32回日本神経科学大会(Neuro2009)
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-09-18
• [Presentation] Mechanisms for polarized sorting of glutamate receptors to the somatodendritic domain of neurons (2008)
  • Author(s): 松田信爾、三浦会里、掛川渉、松田恵 子、幸田和久、渡辺雅彦、柚崎通
  • Organizer: 第31回日本神経科学大会(Neuro2008)
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-11
• [Presentation] Regulation of autophagy in neuronal axons (2008)
  • Author(s): 柚崎通介、西山潤、松田信爾、三浦絵里子、水島昇、渡辺雅彦
  • Organizer: 第31回日本神経科学大会(Neuro2008)
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-11
• [Presentation] グルタミン酸受容体の樹状突起特異的輸送機構 (2008)
  • Author(s): 松田信爾
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-11