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Theory of memory transfer and consolidation in motor learning

Research Project

Project/Area Number 20700301
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

YAMAZAKI Tadashi  独立行政法人理化学研究所, 戦略ユニット, 研究員 (40392162)

Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords小脳 / 運動学習 / 視機性眼球運動 / ゲイン適応 / 記憶の固定化 / モデル / シミュレーション / ロボット制御 / 理論 / 記憶転送 / 大規模シミュレーション / 解析 / 運動記憶の転送 / スパイキングネットワーク
Research Abstract

To understand the neural mechanism of memory transfer phenomenon found in cerebellar motor learning, we built a large-scale computational model of the cerebellum for gain adaptataion of optokinetic response eye movments, which is used as an experimental paradigm for memory transfer phenomenon. We published a paper in an international journal. We studied the learning rule for mossy fiber-vestibular nuclear cell synapses to demonstrate robust memory transfer phenomenon, and found that Bienenstock-Cooper-Munro(BCM) rule is a candidate. We also reported that BCM rule is sufficient to reproduce the spacing effect in motor learning.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (27 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (18 results) Remarks (3 results)

  • [Journal Article] A Computational Mechanism for Unified Gain and Timing Control in the Cerebellum2012

    • Author(s)
      Tadashi Yamazaki, Soichi Nagao
    • Journal Title

      PLoS ONE

      Volume: 7(3) Issue: 3 Pages: e33319-e33319

    • DOI

      10.1371/journal.pone.0033319

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A computational mechanism for unified gain and timing control in the cerebellum2012

    • Author(s)
      Tadashi Yamazaki, Soichi Nagao
    • Journal Title

      PLoS ONE

      Volume: (In Press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小脳の計算機構の完全理解とその応用を目指して2009

    • Author(s)
      山崎匡
    • Journal Title

      日本神経回路学会誌

      Volume: 16(2) Pages: 190-195

    • NAID

      10027011097

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Computational models of timing mechanisms in the cerebellar granular layer2009

    • Author(s)
      Tadashi Yamazaki, Shigeru Tanaka
    • Journal Title

      Cerebellum

      Volume: 8(2) Pages: 423-432

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小脳の計算機構の完全理解とその応用を目指して2009

    • Author(s)
      山崎匡
    • Journal Title

      日本神経回路学会誌 16

      Pages: 190-195

    • NAID

      10027011097

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computational models of timing mechanisms in the cerebellar granular laver2009

    • Author(s)
      Yamazaki, T, Tanaka, S
    • Journal Title

      Cerebellum 8

      Pages: 423-432

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] GPU-based implementation of a cerebellar spiking network model for realtime robot control2011

    • Author(s)
      Tadashi Yamazaki, Jun Igarashi
    • Organizer
      第21回日本神経回路学会全国大会
    • Place of Presentation
      沖縄科学技術大学院大学、沖縄
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Real-time computer simulation of a spiking network model of the cerebellar cortex2011

    • Author(s)
      Tadashi Yamazaki, Jun Igarashi
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Convention Center, Washington DC, USA
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Modeling study for a possible mechanism of spacing effect in cerebellar motor learning2011

    • Author(s)
      Tadashi Yamazaki, Soichi Nagao
    • Organizer
      Fourth International Congress of the Society for Research on the Cerebellum
    • Place of Presentation
      東京大学,東京
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 小脳モデルを用いたSmith Predictorの一構成法と小型ヒューマノイドロボットの腕到達運動への応用2011

    • Author(s)
      山崎匡
    • Organizer
      第29回日本ロボット学会学術講演会
    • Place of Presentation
      芝浦工業大学,東京
    • Year and Date
      2011-09-08
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] A spiking network model of the cerebellar granular layer shows stimulus-dependent state transition between synchronized oscillation and randomly repetitive burst.2010

    • Author(s)
      Honda T, Yamazaki T, et al.
    • Organizer
      7^<th> Forum of European Neuroscience
    • Place of Presentation
      Amsterdam, Neitherlands
    • Related Report
      2010 Annual Research Report
  • [Presentation] A role of constraint in cerebellar learning and memory transfer2009

    • Author(s)
      Tadashi Yamazaki, Soichi Nagao
    • Organizer
      Annual meeting of society for neuroscience
    • Place of Presentation
      Convention center, Chicago
    • Year and Date
      2009-10-19
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 小脳学習と記憶転送における制約条件の役割2009

    • Author(s)
      山崎匡,永雄総一
    • Organizer
      日本神経回路学会全国大会
    • Place of Presentation
      東北大学,仙台
    • Year and Date
      2009-09-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 小脳学習と記憶転送における制約条件の役割2009

    • Author(s)
      山崎匡, 永雄総一
    • Organizer
      日本神経回路学会全国大会
    • Place of Presentation
      東北大学, 仙台
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] タイミング制御の小脳モデル2009

    • Author(s)
      山崎匡
    • Organizer
      Motor Control研究会
    • Place of Presentation
      生理研,岡崎
    • Year and Date
      2009-05-29
    • Related Report
      2011 Final Research Report
  • [Presentation] タイミング制御の小脳モデル2009

    • Author(s)
      山崎匡
    • Organizer
      Motor Control研究会
    • Place of Presentation
      生理研, 岡崎
    • Year and Date
      2009-05-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] A Role of Constraint in Cerebellar Learning and Memory Transfer.2009

    • Author(s)
      Tadashi Yamazaki, Soichi Nagao.
    • Organizer
      Program No.367.7 2009 Neuroscience Meeting Planner.Chicago,IL : Society for Neuroscience,2009.
    • Place of Presentation
      Online.Chicago,IL
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 小脳運動学習と記憶の転送における制約条件の役割2009

    • Author(s)
      山崎匡, 永雄総一
    • Organizer
      日本神経回路学会全国大会(JNNS2009)
    • Place of Presentation
      東北大学,仙台
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] A computational model of the cerebellum for motor-memory transfer2008

    • Author(s)
      Tadashi Yamazaki
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2008-11-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 運動記憶の転送を行う小脳のスパイキングネットワークモデル2008

    • Author(s)
      山崎匡
    • Organizer
      日本神経回路学会
    • Place of Presentation
      つくば
    • Year and Date
      2008-09-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 運動記他の転送を行う小脳のスパイキングネットワークモデル2008

    • Author(s)
      山崎匡
    • Organizer
      日本神経回路学会
    • Place of Presentation
      産総研,つくば
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] A computational model of the cerebellum for motor-memory transfer2008

    • Author(s)
      Tadashi Yamazaki
    • Organizer
      Society for Neuroscience Nov 17
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] A computational model of the cerebellum for motor memory transfer2008

    • Author(s)
      Tadashi Yamazaki, Soichi Nagao
    • Organizer
      38th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC.
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 記憶の転送を行う小脳のスパイキングネットワークモデル2008

    • Author(s)
      山崎匡, 永雄総一
    • Organizer
      日本神経回路学会全国大会(JNNS2008)
    • Place of Presentation
      産総研,つくば
    • Related Report
      2010 Self-evaluation Report
  • [Remarks] シミュレーションプログラムのソースコード

    • URL

      http://cerebellum.neuroinf.jp/modules/xoonips/detail.php?item_id=1344

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      https://github.com/neuralgorithm/Cerebellum

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=144416

    • Related Report
      2011 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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