Investigation of relationship between information acquirement and integration pattern of adult-born neurons into preexisting circuit in hippocampus
| Project/Area Number |
20700311
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | University of Toyama |
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Principal Investigator |
OHKAWA Noriaki University of Toyama, 大学院・医学薬学研究部(医学), 助教 (80416651)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ニューロン新生(神経新生) / 新生ニューロン / 海馬 / 歯状回 / スパイン / 長期増強(LTP) / レトロウイルス / 海馬歯状回 / 神経科学 |
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| Research Abstract |
Newly born neurons are continually being generated in the adult brain. In dentate gyrus of hippocampus, the newborn neurons are functionally integrated into existing circuit. Long-term potentiation (LTP) is a model of the activity-dependent synaptic plasticity which plays a central role in the establishment of memories. We constructed a compatible system of the retrovirus-mediated spine labeling of adult-born neurons and in vivo LTP induction in dentate gyrus to investigate the relationship between the LTP induction and spine formation pattern. Then, our results indicated information acquirement in dentate gyrus differentially regulates the integration of each new neurons progressing in different developmental stages. In addition, the each new neurons progressing in different developmental stages may differentially affect on the acquired information in dentate gyrus.
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Report
(3 results)
Research Products
(12 results)
