| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Neural circuits in the central nervous system are the substrate of various high-order brain functions. Here, we aim to develop a three-dimensional mouse brain atlas of neural circuits using high resolution X-ray microscopy by synchrotron radiation. In this study, a nano-resolution full-field X-ray microscopy revealed synapses in the mouse cerebral cortex. Moreover, phase contrast X-ray tomography unveiled 3D structure of the mouse brain tissue with isometric nano-meter voxel sizes. In the near future, we will utilize that information to begin deciphering the wiring diagram of the developing brain by applying the nano-resolution X-ray microscopy.
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